Inclusion Criteria:

• ≥12 and <18 years old
• Patient weighs ≥18 kg at the time the patient provides written assent
• Females of child-bearing potential must have negative pregnancy test at Visit 1 (serum) and Visit 2 (urine) and confirm the use of appropriate contraception (including abstinence).
• Patient meets the Rome IV criteria for child/adolescent diagnosis of IBS-C
• Patient is willing to discontinue any laxatives used in favor of the protocol-permitted rescue medicine (which will only be allowed after 72 hours with no bowel movement)
• Patient meets the entry criteria assessed during the 2-week Screening period.
• Ability of both the patient and parent/guardian/LAR to communicate with the Investigator and to comply with the requirements of the entire study, including an understanding of the assessments in the eDiary and how to use the eDiary device
• Patient must provide written assent and the parent/guardian/LAR must provide written informed consent before the initiation of any study-specific procedures

Exclusion Criteria:

• Functional diarrhea as defined by Rome IV child/adolescent criteria
• IBS with diarrhea (IBS-D), mixed IBS (IBS-M), or unsubtyped IBS as defined by Rome IV child/adolescent criteria
• History of non-retentive fecal incontinence.
• Required manual disimpaction any time prior to randomization (after consent);
• Has both unexplained and clinically significant alarm symptoms (lower gastrointestinal [GI] bleeding [rectal bleeding or heme-positive stool], iron-deficiency anemia, or any unexplained anemia, or weight loss) and systemic signs of infection or colitis, or any neoplastic process
• Patient has any of the following conditions:
  • Celiac disease, or positive serological test for celiac disease
  • Cystic fibrosis
  • Hypothyroidism that is untreated or treated with thyroid hormone
  • Down's syndrome or any other chromosomal disorder
  • Active anal fissure
  • Anatomic malformations (eg, imperforate anus)
  • Intestinal nerve or muscle disorders (eg, Hirschprung disease)
  • Neuropathic conditions (eg, spinal cord abnormalities)
  • Lead toxicity, hypercalcemia
  • Neurodevelopmental disabilities producing a cognitive delay that precludes comprehension and completion of the daily eDiary (Electronic handheld device)
  • Inflammatory bowel disease
  • Childhood functional abdominal pain syndrome
  • Childhood functional abdominal pain;
  • Poorly treated or poorly controlled psychiatric disorders that might influence his or her ability to participate in the study;
  • Lactose intolerance that is associated with abdominal pain or discomfort
  • History of cancer other than treated basal cell carcinoma of the skin; (Note: Patients with a history of cancer are allowed provided that the malignancy has been in a complete remission for at least 5 years before the Randomization Visit.)
  • History of diabetic neuropathy.
• Use of medications that are known to affect stool consistency (Prohibited Medications), including fiber supplements, anti-diarrheals, cathartics, antacids, opiates, prokinetic drugs, laxatives, enemas, antibiotics during the Screening period; unless specified as rescue medication, and used accordingly as directed by the Investigator.
• Patient has had surgery that meets any of the following criteria:
  • Bariatric surgery for treatment of obesity, or surgery to remove a segment of the GI tract at any time before the Screening Visit;
  • Surgery of the abdomen, pelvis, or retroperitoneal structures during the 6 months before the Screening Visit;
  • An appendectomy or cholecystectomy during the 60 days before the Screening Visit;
  • Other major surgery during the 30 days before the Screening Visit
• History of alcohol or substance abuse
• Participation in other clinical trials within 1 month prior to Screening
• Patient and/or parent/guardian/LAR is involved in the conduct and/or administration of this trial as an investigator, sub-investigator, trial coordinator, or other staff member, or the patient is a first-degree family member, significant other, or relative residing with one of the above persons involved in the trial
• If, in the opinion of the Investigator, the patient is unable or unwilling to fulfill the requirements of the protocol or has a condition, which would render the results uninterpretable