Low-Dose Radiation Therapy for Osteoarthritis: A Prospective Phase Ii Trial to Assess Pain Response
Study on Low-Dose Radiation Therapy for Joint Pain Relief
Arpan Prabhu
Primary Investigator
Brief description of study
Low dose radiation in the treatment of benign diseases, including musculoskeletal disorders such as arthritis, is a standard clinical practice commonly utilized in some practices in the United States and even more commonly utilized in countries in Europe. This study will evaluate patients' pain and quality of life responses to this standard treatment through the use of surveys before and after their treatment for arthritis in our facilities.
Detailed description of study
This research study is designed to systematically collect information on how patients respond to low-dose radiation therapy (LDRT) for osteoarthritis. LDRT has shown promise in managing benign musculoskeletal conditions, including arthritis, by reducing inflammation and alleviating pain. The goal is to understand the benefits, side effects, and impact on pain and quality of life so that future patients may benefit from this knowledge.
Our study will ask patients who are receiving LDRT to complete questionnaires to evaluate their pain levels and quality of life changes with LDRT.
Primary Objective:
1. To assess pain relief of patients treated with LDRT for OA overall and stratified by Kellgren-Lawrence score, an objective grading scale of the severity of OA based on radiographic X-ray findings at baseline.
Secondary Objectives:
1. To assess quality of life of patients treated with LDRT for OA 2. To assess functional outcome scores for patients treated with LDRT for OA 3. To monitor acute and late side effects from LDRT
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Osteoarthritis
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Age: 40 years or above
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Gender: All
Inclusion
Eligible patients must:
• Have a diagnosis of osteoarthritis
• Age of 40 years or older
• Have failed at least one other form of treatment (E.g., oral anti-inflammatory medications, steroidal injection, physical therapy, etc.)
• Have signed consent for treatment with radiation therapy
Exclusion
Ineligible patients are:
• Pregnant or lactating women
• Patients with radiation overlap that would be deemed unsafe per the evaluating radiation physician
• Patients with a previous joint replacement at the site of treatment
This study investigates the use of low-dose radiation therapy (LDRT) for treating osteoarthritis, a condition that causes joint pain and stiffness. Osteoarthritis is a common form of arthritis where the protective cartilage that cushions the ends of bones wears down over time. The purpose of this study is to evaluate how LDRT affects pain and quality of life in patients with osteoarthritis.
Participants will receive LDRT and complete surveys about their pain levels and quality of life before and after treatment. These surveys help researchers understand the effectiveness of LDRT in managing osteoarthritis symptoms. The study will also monitor any side effects from the treatment.
- Who can participate: Adults aged 40 years or older with a diagnosis of osteoarthritis are eligible. They must have not responded to other treatments like medications or physical therapy, must not be pregnant, and should not have had a joint replacement at the treatment site.
- Study details: Participants will receive LDRT and complete surveys about their pain and quality of life before and after the therapy.
