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Inclusion Criteria:
1. Have been diagnosed with depression and currently experiencing a depressive episode for at least 12 months, or have symptoms that continue to come back
2. Open to considering an investigational surgical option for depression treatment
3. Willing to get copies of your records for the last few years from psychiatrist to provide to our team
4. Have tried at least four treatments and not found them helpful, including:
- Difference medications like Zoloft, Prozac, Lexapro, Wellbutrin, Paxil, Effexor, Cymbalta, and/or combinations of these with other medications
- Cognitive behavioral therapy, psychotherapy, or other talk therapies
- Transcranial magnetic stimulation
- Electroconvulsive therapy
5. Ability to commit to regular visits for over the course of 3 years
6. Willing to transfer psychiatric medical care to the study psychiatrist for a 12-month period
Exclusion Criteria:
1. Pregnant or those who plan to become pregnant during study
2. Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that could limit participation in the study or interfere with adherence to the study protocol.
3. Current or lifetime history of psychotic features in any Major Depressive Episode.
4. Has an intracranial Central Nervous System disease that impairs motor, sensory or cognitive function or that requires intermittent or chronic medication.
5. Significant acute suicide risk.
6. Diagnosis of Substance Use Disorder or Alcohol Use Disorder without sustained remission (12 months or longer).
7. Current and ongoing use of neurostimulation treatment that may interfere with DBS therapy/system.
8. Treatment with another investigational device or investigational drugs.
