Bespoke Pan Cancer

Primary Investigator
H
Hristos Kaimakliotis, MD

Primary Investigator

Enrolling By Invitation
18 years - 100 years
All
Phase N/A
20 participants needed
1 Location

Brief description of study

This is a prospective, multi-center, single arm study focused on data and sample collection from participants diagnosed with Stage I to IV cancers and for whom standard of care Natera MRD
testing has been ordered (for example, SignateraTM, SignateraTM Genome, or LatitudeTM). This study will utilize study sites located within the United States of America (USA). The primary objective is to establish a comprehensive data repository to support the development and validation of cancer monitoring and detection tests.  The goal of this study is to clinically characterize biomarkers associated with development and validation of cancer monitoring and detection tests (“Natera cancer monitoring and detection test(s)”). The primary endpoint of this study is to obtain anonymized clinical data from up to 5,000 participants.

THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic. 
 
Interested in participating? For more information about this research study or other cancer-related clinical trials at Indiana University Simon Comprehensive Cancer Center (IUSCCC), please contact the
IU Clinical Trials Office: 
Phone: (317) 278-5632

Detailed description of study

Potential participants will be identified through various recruitment outreach efforts that allow methods outlined below. These various recruitment methods are being utilized in order to reach a more diverse population to remove potential barriers to underrepresented or hard to reach populations. Final eligibility will be assessed by the Site Investigator:
 
Data may be participant reported data or derived from medical records.  Data may be used to inform the development of cancer-related tests and non-cancer-related tests (including, but not limited to, organ health, comorbidities, immune response and inflammation research.
 

The study will enroll participants for up to 36 months, with each participant followed for up to 5 years after enrollment. Total study duration will be approximately eight (8) years from the first participant enrolled to the last participant’s final visit. 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Primary malignancy, Solid tumor, Hematologic malignancies, Cancer
  • Age: 18 years - 100 years
  • Gender: All

Participants must meet all the following selection criteria to be eligible for the
study.:
1. 18 years of age or older
2. Participant has a primary malignancy including any solid tumor and
hematologic malignancies
3. Selected by their treating physician to undergo serial testing with a
clinically-available Natera MRD test according to the current evidence-
informed schedule
4. Signed informed consent(s) must be obtained prior to participation in the
study
5. Willing and able to comply with the study requirements

Participants are not eligible for the study if they meet any of the following
criteria, as assessed by the Site Investigator:
1. Pregnant or breastfeeding
2. History of bone marrow or organ transplant
3. Serious medical conditions that may adversely affect ability to
participate in the study

Updated on 14 Aug 2026. Study ID: 31214
Please visit our main page to search for other studies you may be interested in. If you need help finding a study or have any questions, please contact us at inhealth@iu.edu

Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only