International Paediatric Stroke Study Protocol (IPSS): Towards the Establishment of Standards of Practice and the Initiation of Multi-Center, Multi-National Clinical Trials for Neonates and Children with Stroke

Research Study on Pediatric Stroke in Neonates and Children

Primary Investigator
R
Rabia Qaiser

Primary Investigator

Enrolling By Invitation
17 years or below
All
Phase N/A
5 participants needed
1 Location

Brief description of study

The International Pediatric Stroke Study (IPSS) was established in 2003 as a multi-center, multi-national clinical research registry. Over the years, it has grown to become a highly successful study vehicle for pediatric stroke research across over 100 institutions worldwide. Today, The IPSS continues to serve as the global clinical data and imaging core for multi-disciplinary pediatric experts who perform international collaborative research to better understand, prevent, and improve outcomes in pediatric stroke. The robust dataset and cohesive network enable high caliber and ground-breaking research in the field. This is the first multi-center, multi-national study of children with stroke. It seeks to build a network of investigators and high-quality disease dataset to enable population-based studies, natural history studies, and clinical trials to improve the care of children with stroke.

THIS STUDY IS ENROLLING BY INVITATION ONLY - Participating sites enroll neonates or children who have had an ischemic or hemorrhagic stroke, or may be at high risk of having a stroke. Participants have their medical and research records reviewed for information about their stroke and abstracted into a secure electronic database called REDCap, which is hosted at SickKids in Toronto Canada. The IPSS also provides an attractive imaging platform (through the Stroke Imaging Lab for Children, SILC, housed at SickKids) for sites to share clinically acquired brain images that will complement the clinical dataset. The clinical and imaging datasets will improve our understanding of the processes underlying plasticity and recovery in childhood stroke.

Detailed description of study

This study includes a data collection component and collaborative process. Our network of over 150 investigators prospectively collect data on neonates or children with a diagnosis of stroke made after January 2003.

Data on stroke diagnosis, etiology, treatment and outcomes are collected and entered into a secure web system, REDCap.

 Neuro-imaging data from the index event and a series of follow-up time points are captured and stored in the SILC-IPSS data repository.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Ischemic Stroke, Cerebrovascular Accident, Focal Infarct, Riley
  • Age: 17 years or below
  • Gender: All

Inclusion criteria:

  • Infants and children with ischemic stroke (arterial ischemic stroke and cerebral sinovenous thrombosis), hemorrhagic stroke or those at high risk (e.g. arteriopathies like moyamoya).

The purpose of this study is to investigate pediatric stroke in neonates and children. Stroke is a medical condition where the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients. This study focuses on understanding the causes and outcomes of stroke in children, and involves collecting data from many different hospitals around the world.

Participants in the study will have their medical records reviewed, and information about their stroke will be collected and stored in a secure electronic database. The study also includes sharing brain images to better understand how children recover from strokes. This information will help researchers learn more about stroke recovery in children.

  • Who can participate: Infants and children who have had an ischemic or hemorrhagic stroke, or who are at high risk for stroke, such as those with arteriopathies like moyamoya, can participate.
  • Study details: Participants will provide access to their medical records and undergo imaging procedures to collect data for the study. Medical and research records will be reviewed for stroke information, which will be stored in a secure database. Brain images will also be shared to complement this data.
Updated on 06 Aug 2026. Study ID: 31177
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Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only