Inclusion Criteria
Confirmation of diagnosis:
Phase I: Patients must have histologic verification of a solid tumor or lymphoma malignancy at diagnosis for which there is no standard curative anti-cancer treatment or treatment is no longer effective and must have received greater than or equal to 1 prior line of therapy.
Phase II: patients must have histologically verified tumor at initial diagnosis and radiologically or histologically confirmed status at inclusion as indicated in the following: neuroblastoma, osteosarcoma, rhabdomyosarcoma or Ewing sarcoma.
Patients with solid tumors must have measurable or evaluable (for neuroblastoma and Ewing sarcoma) disease.
Adequate bone marrow, renal and liver function.
Exclusion Criteria
Active or uncontrolled infection
History or concurrent condition of interstitial lung disease of any severity and/or severely impaired lung function (as judged by the investigator)
Diabetes mellitus
Uncontrolled arterial hypertension despite optimal medical management (per institutional guidelines)
Patients with central nervous system (CNS) malignancies

Additional Information:

Participants will not be paid for their participation.