Changes in Esophageal Distensibility with Proton Pump Inhibitors in Patients with Esophageal Eosinophilia: A Pilot Study
John Wo, MD
Primary Investigator
Brief description of study
What is the purpose of this study?
The purpose of this study is to measure the stiffness of the esophagus before and after treatment for inflammation in the esophagus.
Detailed description of study
What will happen during the study?
Participants who qualify and are undergoing endoscopy will complete a short survey before their endoscopy, and agree to have the stiffness of their esophagus measured to see whether they could be at risk for esophageal impactions.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Esophageal Eosinophilia
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Age: 18 years - 65 years
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Gender: All
Inclusion Criteria:
1. Diagnosis of Eosinophilic Esophagitis, as defined by a peak count of > 15 eosinophils per high power field (HPF) on light microscopy based on esophageal biopsies.
q23235
Exclusion Criteria:
1. Patients whose elevated eosinophil count on esophageal biopsies are thought to be due to another condition such as eosinophilic GI diseases, GERD, celiac disease, Crohn’s disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease
2. Age < 18 or > 65 years
3. Contraindication for biopsy, such as presence of esophageal varices, coagulopathy
4. History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)
5. History of esophageal perforation
6. History of esophageal stent placement
7. Pregnancy
8. Prisoners
