Advanced Imaging of Ongong Vasculopathy in Intracerebral Hemorrhage

MRI Techniques in Brain Bleeding

J
Jason Mackey

Primary Investigator

Enrolling By Invitation
18 years - 100 years
All
Phase N/A
1 Location

Brief description of study

he purpose of this study is to demonstrate that advanced MRI techniques can help predict ICH (intracerebral hemorrhage) outcomes and improve our understanding of the functional changes associated with or resulting from acute-phase ICH.

THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential subjects will present to IU Health Methodist Hospital-Emergency Department, IUHMH-ED, either directly or be transferred into IUH Methodist Hospital from an outside hospital. Study personnel will review IUHMH-ED, Neurocritical Care, and various hospital floor (5N, 5S, etc.) patient lists to identify potential subjects. Radiology reports will be reviewed once available and patients with reports consistent with ICH will be further reviewed to determine full eligibility for the study.

Detailed description of study

This study will collect new and different imaging pilot data on short-term changes in the circulation of the blood in the smallest blood vessels within the brain of the subjects following an ICH using advanced MRI imaging at baseline and at 90 days post-ICH. It will also aid in determining the association between these imaging markers of ongoing disease of the blood vessels and the 90-day post ICH to return to pre-stroke functioning capacity and conscious mental activities (such as thinking, understanding, learning, and remembering) outcomes. Subjects enrolled in the study will receive standard of care medical care.  This is not an interventional trial. 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Intracerebral Hemorrhage (ICH)
  • Age: 18 years - 100 years
  • Gender: All

Inclusion:
1. Subjects ≥18 years of age
2. Diagnosed with ICH 
3. Ability to undergo MRI as defined by the IU Health MRI Contrast Media Policy
4. English Speaking (in order to complete cognitive testing)

Exclusion:  
1. Traumatic ICH, aneurysm, arteriovenous malformation, cavernoma, encephalitis, craniotomy, or brain tumor as a cause of the hemorrhage
2. Hemorrhagic transformation of an ischemic infarct or hemorrhage due to venous sinus thrombosis, carotid endarterectomy, or thrombolytic administration for ischemic stroke
3. Contraindication to brain MRI or inability to tolerate brain MRI
4. Pregnancy
5. Patient in hospice at the time of ICH or those with comfort measures only within the first 24 hours
6. Any significant condition that in the Investigator’s judgment, may affect the subject’s ability to complete the study, either clinically or distance to the study site (i.e. resides in another state, or country).
 

 

 

This study investigates the use of advanced MRI techniques to predict outcomes in patients who have experienced an intracerebral hemorrhage (ICH). Intracerebral hemorrhage is a type of stroke caused by bleeding within the brain. The study aims to understand how these advanced imaging techniques can show changes in brain function during the acute phase of ICH.

Participants will undergo advanced MRI imaging at the start of the study and again 90 days after the ICH to observe changes in the smallest blood vessels in the brain. The study will look for links between these imaging results and the participants' ability to return to their normal activities and mental functions, such as thinking and remembering. This study is observational, meaning it collects data without changing any treatments.

  • Who can participate: Adults 18 and older with intracerebral hemorrhage who can have an MRI and speak English are eligible. Those with traumatic brain injuries or certain medical conditions are not.
  • Study details: Participants will have MRIs at the beginning and 90 days after their intracerebral hemorrhage to monitor changes in brain blood vessels. The study does not alter standard medical care.
Updated on 28 Oct 2025. Study ID: NEUR-IUH-MACK-ADVANCE, 1407493345
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Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only