Identification of Serum and Urine Biomarkers of Type 1 Diabetes

C
Carmella Evans-Molina, MD

Primary Investigator

Identification of Serum and Urine Biomarkers of Type 1 Diabetes
Enrolling By Invitation
1 years - 95 years
All
Phase N/A
1 Location

Brief description of study

What is the purpose of this study?
The purpose of this study is to identify biomarkers (small molecules in the blood) that can predict those people at risk of developing Type 1 diabetes.
 
THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants will be recruited in various ways for different aims by the research team and contacted or invited to participate.  At Indiana University, patients with newly diagnosed T1D will be approached whenever possible when inpatients at diagnosis and then recontacted after discharge. At IU, visits will be conducted at our Indiana Clinical Research Center (ICRC) and Riley Children's Hospital during inpatient new diagnosis stays, and coordinated with diabetes clinic follow-up visits when possible. Subjects will also be recruited through the CRC by identifying subjects already enrolled in a Type 1 diabetes study. Subjects at risk for T1D will also be recruited through the T1D at risk clinic.

Detailed description of study

What will happen during the study?

Aim 1: Collection and biobanking of blood and urine from subjects recently diagnosed with T1D for biomarker evaluation.
Aim 2: Biobanking samples from ongoing mixed-meal tolerance testing (MMTT) or oral glucose tolerance testing (OGTT).
Aim 3: Performance of MMTT in healthy, non-diabetic adults and pediatrics, and biobanking of resulting samples.
Aim 4: Collection and Biobanking of samples in healthy non-diabetic adults and children.
 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Type 1 Diabetes, T1D, Healthy
  • Age: 1 years - 95 years
  • Gender: All

Inclusion Criteria:
  • Healthy adult or child without diabetes or new type 1 diabetic within 7 days of diagnosis by a physician.
Exclusion Criteria:
  • Pregnant
  • Current smoker
  • Psychiatric impairment or current use of anti-psychotic medication
  • Chronic illness known to affect glucose metabolism or taking medications known to affect glucose metabolism

Updated on 05 Apr 2025. Study ID: ENDO-NIH-ISUBT1D, 1411938757
Please visit our main page to search for other studies you may be interested in. If you need help finding a study or have any questions, please contact us at inhealth@iu.edu

Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting referrals by invitation only