Pathogenesis and molecular mechanisms underlying pulmonary diseases
R
Ryan Boente
Primary Investigator
Not Recruiting
18 years - 100 years
All
Phase
N/A
1 Location
Brief description of study
The research goal is to understand the pathogenesis and molecular mechanisms of pulmonary disease and find new ways to detect, treat, and maybe prevent or cure lung diseases. Our study goals are to analyze lung tissue samples for molecular markers, gene expression profiles and other cellular features. Tissue samples and medical information will be collected so researchers can use them in future studies to understand the causes of diseases, and develop new treatments.
THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects will be identified by the IU Health Lung Transplant team and that team will then notify the research coordinator about a potential subject. The research coordinator will approach the patient at a standard of care visit after the PI or sub investigator has explained this study.
Detailed description of study
This protocol requests the ability to receive de-identified human lung excess tissue and any excess lymph node tissue that is taken for standard of care from explants that are either resected at the time transplant or are derived from donor lungs that are unsuitable for use in transplantation at Indiana University Health Methodist Hospital. Blood samples and de-identified medical record data may also be requested to guide discovery. IUH will be de-identifying these samples and then send the samples to University of Cincinnati
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Pulmonary disease, Lung disease, Lung transplant
-
Age: 18 years - 100 years
-
Gender: All
Inclusion criteria:
- Must be having a lung transplant and can be of any gender and must be 18 years of age or older
Exclusion criteria:
• Lungs will not be accepted from patients with known chronic viral infections, including but not limited to Hep C, Hep B, HIV, EBV or CMV.
• Explants not able to be shipped same day.
Updated on
23 Dec 2025.
Study ID: ECRO-UC-TISSUECOLL, 1803517135
