Pathogenesis and molecular mechanisms underlying pulmonary diseases

R
Ryan Boente

Primary Investigator

Enrolling By Invitation
18 years - 100 years
All
Phase N/A
1 Location

Brief description of study

The research goal is to understand the pathogenesis and molecular mechanisms of pulmonary disease and find new ways to detect, treat, and maybe prevent or cure lung diseases. Our study goals are to analyze lung tissue samples for molecular markers, gene expression profiles and other cellular features. Tissue samples and medical information will be collected so researchers can use them in future studies to understand the causes of diseases, and develop new treatments.
 
THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects will be identified by the IU Health Lung Transplant team and that team will then notify the research coordinator about a potential subject. The research coordinator will approach the patient at a standard of care visit after the PI or sub investigator has explained this study.

Detailed description of study

This protocol requests the ability to receive de-identified human lung excess tissue and any excess lymph node tissue that is taken for standard of care from explants that are either resected at the time transplant or are derived from donor lungs that are unsuitable for use in transplantation at Indiana University Health Methodist Hospital. Blood samples and de-identified medical record data may also be requested to guide discovery. IUH will be de-identifying these samples and then send the samples to University of Cincinnati

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Pulmonary disease, Lung disease, Lung transplant
  • Age: 18 years - 100 years
  • Gender: All

Inclusion criteria:

  • Must be having a lung transplant and can be of any gender and must be 18 years of age or older

Exclusion criteria:

• Lungs will not be accepted from patients with known chronic viral infections, including but not limited to Hep C, Hep B, HIV, EBV or CMV. 

• Explants not able to be shipped same day.

Updated on 16 Dec 2025. Study ID: ECRO-UC-TISSUECOLL, 1803517135
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Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only