Randall's Plaques: Pathogenesis and Relationship to Nephrolithiasis

J
James Lingeman, MD

Primary Investigator

Enrolling By Invitation
100 years or below
All
Phase N/A
3 Locations

Brief description of study

The purpose of this study is to thoroughly examine kidney stones, kidney tissue, urines, and medical history of patients to help determine causes and/or the most effective treatments, including preventative treatments, of kidney stones.
 
THIS STUDY IS ENROLLING BY INVITATION ONLY 

Detailed description of study

In order to attempt to explain the pathogenesis of renal calculi, the investigators videotape and document the location and characteristics of each stone, papillae and calyces. One or more small papillary biopsies are taken for analysis to help determine the point of origin of the kidney stone and histological studies are undertaken to determine tissue differences amongst different types of stone formers. Approximately one month after surgery, metabolic studies are undertaken to further review potential causes of stone formation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Nephrolithiasis, Kidney stones, Renal calculi
  • Age: 100 years or below
  • Gender: All

Inclusion Criteria:

  • Patients of Methodist Urology in Indianapolis, IN who are undergoing endoscopic procedures for nephrolithiasis or other urologic disease.
  • Upper urinary tract endoscopic or PERC procedure for kidney stones removal
  • General medical health allowing surgical procedure
  • Ability to complete all the necessary components of the study
  • Able to sign an informed consent

Exclusion Criteria:

  • Poor general medical health
  • Bleeding diathesis
  • Inability or unwillingness to comply with post-surgical follow-up

Updated on 16 Dec 2025. Study ID: UROL-IIR-LINGEMAN-RP, 1010002261
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Interested in the study?

This study is accepting only persons who receive care at a certain clinic or doctor or who are part of an invited group. Questions about this study can be directed to the study team listed in the description or contact your doctor to see if you are eligible.

Accepting Referrals by Invitation Only