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Found 742 results
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Nicotinic Acid for the treatment of Alzheimer's Disease Protocol Type: Interventional
J
Jared Brosch, MD
The primary objective of this study is to collect data on the penetration of commercially available, FDA approved, extended-release niacin into the spinal fluid. One dose of 500 mg nicotinic acid will be used (in addition to placebo) to build a dose response curve for this compound in human cerebrospinal …
A phase 2, randomised, multi-centre, open label trial to evaluate the safety and efficacy ofintravesical nadofaragene firadenovec alone or in combination with chemotherapy(gemcitabine and docetaxel) or immunotherapy (pembrolizumab) in subjects with high-grade Bacillus Calmette-Guerin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC) (ABLE-22)
H
Hristos Kaimakliotis, MD
The pivotal phase 2 trial (rAd-IFN-CS 003) evaluating the efficacy of nadofaragene firadenovec showed that 55 (53.4%) of 103 subjects with CIS ± high-grade Ta/T1 achieved a complete response (CR) at 3 months. In this trial, the safety and efficacy of intravesical instillation of nadofaragene firadenovec alone or in combination …
Phase I/II Trial of Lurbinectedin with Osimertinib in Transformed Small Cell Lung Cancer
M
Misty D. Shields, MD, PhD
Primary Objective:To assess the efficacy of the combination of lurbinectedin with osimertinib in patients with EGFR altered non-small cell lung cancer (NSCLC) with documented transformation to SCLC, after the use of EGFR tyrosine kinase inhibitor osimertinib.Secondary ObjectiveTo evaluate the safety of the combination of lurbinectedin with osimertinib in patients with …
PSMAcTION: A phase II/III, open-label, international, multi-center, randomized study of AAA817 versus standard of care in the treatment of adult participants with PSMA-positive metastatic castration-resistant prostate cancer who progressed on or after [177Lu]Lu-PSMA targeted therapy.
N
Nabil Adra, MD
This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after [177Lu]Lu-PSMA targeted therapy.Treatment of interest: the investigational treatment is AAA817 regardless of subsequent anti-neoplastic treatment. The control treatment is …
Adolescents Needed for Sweetened Beverages Study
N
Nana Gletsu Miller
Why is this study being done?The goal of this study is to better understand how preferences for sweet flavors affect dietary habits, heart and metabolic health. Who can take part?We are looking for adolescents (ages 12-18) who consume sugary sodas and their families (only one parent/guardian can participate). Participants must also …
The Biopsychosocial Interactions in Adolescent Relationships and Development Study (BIRD)
N
Natasha Chaku, PhD
Why is this study being done?The interACT Lab at Indiana University is looking for eager, dynamic, and curious youth to participate in the BIRD Study. We want to earn more about the complex relationships between puberty, cognition, social relationships, and health in adolescents. The goal of this study is to …
Cystic Fibrosis CFTR Modulator Study
E
Emma Tillman
We hope to generate data through the variability in medication concentrations in a persons blood. We do not know yet if drug concentrations correlate with side effects. This study will help determine if CFTR modulator blood concentrations correlate with medication side effects and determine the value of proceeding with a …
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults with Cancer
T
Tarah Ballinger, MD
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not …
A Phase II Study of Amivantamab SC (subcutaneous) in Participants with MET Amplification-Positive Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Sub-Study)
R
Rohan Maniar
What is the purpose of this study?This phase II Expanded Lung-MAP treatment trial tests how well amivantamab-subcutaneous (SC) works in treating patients patients with MET amplification non-small cell lung cancer. Amivantamab-SC is a drug that reduces extra copies of the MET gene, a change present in your tumor. Giving amivantamab-SC …
Women Undergoing Natural Perimenopause Needed for Study
L
Laura Murray-Kolb
Why is this study being done?Researchers at Purdue University are doing a study to learn more about how iron levels affect women's qualify of life and cognitive function during perimenopause. Potential findings from this study may help us to better understand how nutrition affects perimenopausal women. This may then help …
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