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Found 766 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigational Treatment Study for Platinum-Resistant Ovarian Cancer

L
Lisa Landrum, MD, PhD, MS
18 years or above
Female
Phase 3
Interventional
This study investigates treatments for women with platinum-resistant epithelial ovarian cancer, which is a type of cancer that does not respond to platinum-based chemotherapy. The purpose is to compare the effects of different treatments, including an investigational medication called nemvaleukin, either alone or in combination with another treatment, pembrolizumab, against …
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TArgeting Type 1 Diabetes Using POLyamines (TADPOL) (TADPOL)

E
Emily Sims, MD
6 years - 40 years
All genders
Phase 2
Interventional
The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question[s] it aims to answer are:Does it reduce stress on the cells that make insulin?Does it preserve what is left of the body's insulin production? Participants will …
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A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With The Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

B
Bryan Schneider, MD
18 years - 100 years
All genders
Phase 3
Interventional
What is the purpose of this study?This Phase III, randomized, open-label, multicenter study will evaluate the efficacy andy of giredestrant plus everolimus compared with the physician's choice of endocrineherapy plus everolimus in participants with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer …
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Gastroschisis Outcomes of Delivery (GOOD) Study

H
Hiba Mustafa, MD
18 years or above
Female
Phase 3
Interventional
The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectantgement with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we willdomized, prospective, multi-institutional trial …
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Neoadjuvant pembrolizumab in patients with muscle-invasive bladder cancer with selective bladder sparing

J
Jennifer King
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?Subjects with cT2-T3N0M0 urothelial cancer of the bladder will be enrolled. After completingwo cycles of pembrolizumab, subjects will undergo a restaging MRI of the abdomen and pelvis with a standard acquisition protocol (as outlined in the protocol) as well as CT chest. A CThe …
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Study on Treatment After Initial Therapy for Residual Triple Negative Breast Cancer

B
Bryan Schneider, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates treatments for patients with residual triple negative breast cancer, a type of breast cancer that does not have estrogen, progesterone, or HER2 receptors. The study uses circulating tumor DNA (ctDNA) to assign participants to different treatment arms based on their genomic markers. Participants with ctDNA positivity and …
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Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors

M
Malaz Boustani, MD
65 years or above
All genders
Interventional
This study will evaluate the usefulness of the Emergency General Surgery (EGS) Delirium Recovery Model. It is hypothesized that the cognitive, physical and psychological recovery ofder EGS delirium survivors will be improved through the use of the EGS Delirium Recoverydel. Participants can expect to be on the study for 18 …
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Study of Investigational Treatment for HER2-positive Breast Cancer

T
Tarah Ballinger, MD
18 years or above
All genders
Phase 2
Interventional
This study investigates treatments for people with HER2-positive breast cancer. HER2-positive means that the cancer cells have more HER2 protein than normal, which can cause cancer cells to grow. The study looks at using a combination of investigational medication injections and hormone therapy after surgery. The investigational medications are trastuzumab …
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Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI)

M
Mohammed Madmani, MD
R
Rolf Kreutz, MD
18 years or above
All genders
Phase 3
Interventional
This study will randomize patients recently discharged from the hospital with a confirmed diagnosis of type 1 acute myocardial infarction (Thygesen et al. 2018) and having additionaldiovascular risk factors.
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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection (HIKO STEC)

M
Myda Khalid
9 months - 21 years
All genders
Phase 3
Interventional
The objective of this study is to determine if early high volume intravenous fluiddministration (hyperhydration) may be effective in mitigating or preventing complications ofhiga toxin-producing E. coli (STEC) infection in children and adolescents when compared withditional approaches (conservative fluid management).
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