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Found 743 results

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)

S
Scott Goebel, MD
1 month - 79 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Captureystem will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary …

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

S
Scott Coven
1 year - 25 years
All genders
Phase 1
Interventional
This phase I trial studies the side effects and best dose of trametinib and everolimus ing pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth.verolimus is a drug that may block another pathway …

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

B
Brian Weiss
12 months - 30 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits ofgavivint in treating patients with solid tumors that has come back (recurrent) or does notd to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help …

Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

S
Scott Goebel, MD
1 month - 79 years
All genders
Phase 2
Interventional
What is the purpose of this study?Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with theyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in inhildren, adolescents and young adults with refractory ADV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) ord organ …

Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)

S
Scott Goebel, MD
1 month - 30 years
All genders
Phase 2
Interventional
What is the purpose of this study?CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ …

A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor.

S
Sandeep Batra, MD
3 years - 30 years
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients withgerminomatous germ cell tumors (NGGCT) that have not spread to other parts of the brainbody (localized). This study has …

Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes (iGDM)

C
Christina M. Scifres, MD
18 years - 45 years
Female
Interventional
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.

Biomarker of Diabetic Retinopathy

A
Ashay D. Bhatwadekar, PhD, MPHARM
18 years or above
All genders
Observational
What is the purpose of this study?Diabetic retinopathy is characterized by damage to retinal blood vessels. At present, there is no diagnostic marker reflecting retinal vascular health. By studying RNA content (genetic material that makes proteins) in highly specialized cells in circulating blood resembling blood vessels, we will discover biomarker …

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

D
David Clark
18 years or above
Accepts healthy volunteer
All genders
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents thezed integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD2019 and beyond.

A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

N
Noel Dasgupta
18 years or above
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the safety and tolerability of extended dosing withwith hereditary transthyretin-mediated amyloid polyneuropathy (hATTR-PN).
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