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Found 760 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)

A
Ankit Desai
18 years - 85 years
All genders
Phase 3
Interventional
What is the purpose of this study?The study will evaluate the efficacy and safety of chronic oral levosimendan compared with placebo in PH-HFpEF subjects. This subject population represents a large and growing group with no established therapies to treat their PVD and RV dysfunction. Levosimendan and its prolonged active metabolite, …
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A Real-World Comparative Effectiveness Trial Of Treatment Strategies In Patients With Rheumatoid Arthritis: The RA-PRO (Patient-Reported Outcomes) Pragmatic Trial (RA-PROPR)

S
Sneha Pai
18 years - 100 years
All genders
Interventional
What is the purpose of this study?The purpose of the study is to assess whether replacing their current TNF-biologic with a non-TNF-biologic is superior to adding a targeted synthetic DMARD (disease-modifying anti-rheumatic) medication with active RA despite current TNF-biologic treatment. THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients who have …
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Study on Investigational Medication with Intensive Therapy for High-Risk Neuroblastoma in Children

M
Marissa Just
1 years - 30 years
All genders
Phase 3
This study investigates the effectiveness of adding an investigational medication to standard chemotherapy and other treatments in children with high-risk neuroblastoma. Neuroblastoma is a type of cancer that usually affects young children and develops from immature nerve cells. The investigational medication is a monoclonal antibody that targets a molecule found …
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Investigating Chemoradiation (Combination of Chemotherapy and Radiation Therapy) for Early Stage Vulvar Cancer

S
Sharon E. Robertson
18 years - 100 years
Female
Phase 2
This study investigates the safety of using chemoradiation instead of surgery for early stage vulvar cancer. Vulvar cancer is a type of cancer that affects the external female genitalia. In some cases, cancer spreads to nearby lymph nodes. This study looks at patients with a macrometastasis, which means the cancer …
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Microbiome alterations in the setting of intestinal failure associated liver disease

K
Katie Huff
18 months or below
All genders
What is the purpose of this study?Neonates who require prolonged IV nutrition (TPN) are at risk for such complications as intestinal failure associated liver disease (IFALD). In addition, it is also known that TPN and lack of nutrition through the GI tract influences the intestinal microbiome or bacteria present in …
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Cardiovascular Health Study in Testicular Cancer Survivors

N
Nabil Adra, MD
18 years - 100 years
Male
The purpose of this study is to investigate the long-term effects of chemotherapy and bone marrow transplant on the heart health of testicular cancer survivors. Testicular cancer often affects young adult males, and the treatment can include chemotherapy with platinum-based drugs. This study looks at changes in cholesterol, hormones, and …
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Ovarian Tissue Cryopreservation for Fertility Preservation in Pre and Post-Pubertal Children, Adolescents and Adults Facing a Fertility Threatening Diagnosis or Treatment Regimen

A
Amanda J. Saraf, DO
17 years or below
Female
What is the purpose of this study?Define and follow-up with the patients that undergo OTC for fertility preservation.Optimize techniques and quality assurance measures for freezing and thawing of ovarian tissue or gametesEstablish techniques for in vitro follicle maturation (IFM) or in vitro maturation of cumulus oocyte complexesInvestigate factors affecting successful …
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Craniosynostosis Patient-Reported Outcomes Using the FACE-Q Scales: A Prospective Observational Study

K
Katelyn Makar
21 years or below
All genders
Observational
What is the purpose of this study?Craniosynostosis can affect normal brain development by causing local or regional increases in intracranial pressure. The goals of surgery in the treatment of craniosynostosis are to improve the appearance and morphology of the skull and to prevent functional disturbances such as intracranial hypertension and …
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The Hospital @ Home Model of Care: A Novel Healthcare Solution for the Management of Decompensated Cirrhosis

M
Miranda Stovall
A
Archita Desai, MD
18 years - 100 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to work with patients diagnosed with end-stage liver disease to understand their perspectives on the Health at Home (H@H) Program, including desired outcomes and expectations, perceived barriers and drivers.  H@H is an emerging model of home-based care, designed …
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An open-label, phase II proof-of-concept study to evaluate the clinical efficacy and safety of tapinarof for adult patients with palmoplantar keratoderma

D
David Rosmarin
18 years - 75 years
All genders
Phase 2
Interventional
What is the purpose of this study?This study is being done to find out how safe and how well the drug Tapinarof (VTAMA) works for stopping or treating palmoplantar keratoderma, which is a condition characterized by thickened skin on your palms and soles.  Tapinarof, used as a topical 1% cream, …
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