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Found 743 results
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Letermovir Prophylaxis for Cytomegalovirus in Pediatric Hematopoietic Cell Transplantation
A
April Rahrig, MD
This phase III trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant. The treatments used to prepare for HCT reduce the body's natural infection-fighting ability and increase the likelihood of an infection with a virus called …
Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors (ADEPT-ICU)
B
Babar Khan, MD
What is the purpose of this study?Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer’s disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT …
A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)
M
Mateusz Opyrchal, MD, PhD
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
N
Noel Dasgupta
What is the purpose of this study?To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM.
Transperitoneal vs Extraperitoneal Retroperitoneal Lymph Node Dissection: A Prospective Randomized Controlled Trial
T
Timothy Masterson
We intend to compare an alternative way of performing cancer surgery for those who have testis cancer. This alternative technique is called extraperitoneal RPLND which has been published in retrospective studies. Its benefits, however, remain to be proved in a prospective study. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
Pregnancy Data Repository to Assess Management of Type 1 Diabetes with Diabetes Technology (PRAM-T1D)
C
Christina M. Scifres, MD
What is the purpose of this study?The study is being done because we want to learn more about how people with type 1 diabetes in the United States manage their diabetes during pregnancy. We will enroll pregnant individuals with type 1 diabetes to participate in the PRAM-T1D registry, which will …
Continuous Glucose Monitoring for Gestational Diabetes: An Ancillary Study to the iGDM Trial
C
Christina M. Scifres, MD
What is the purpose of this study?The purpose of this ancillary study to the iGDM randomized clinical trail is to determine whether CGM can reveal additional information about maternal glucose values above and beyond the information obtained from checking blood glucose values 4 times per day. THIS STUDY IS ENROLLING BY …
Outcomes of Stent Placement in Adults with Idiopathic Intracranial Hypertension and Venous Sinus Stenosis
B
Bradley N. Bohnstedt, MD
Venous sinus stenosis has been identified as a potential etiology in Adults with Idiopathic Intracranial Hypertension (IIH). IIH can lead to significant disability including loss of vision, disabling headaches, and neurocognitive impairment. This study will analyze outcome data of stenting in adult patients with IIH and venous sinus stenosis. THIS STUDY …
A Phase 3, Prospective, Open-label, Uncontrolled, Multicenter Study onEfficacy and Safety of Prophylaxis with rVWF in Children Diagnosed With Severe von Willebrand disease
K
Kerry Hege, MD
What is the purpose of this study?The main aim of the study is to evaluate the effectiveness of prophylaxis with recombinant von Willebrand factor (rVWF) in children. This study will enroll those participants who have been previously treated with VWF product or with a plasma-derived VWF (pdVWF) product.
AN OBSERVATIONAL, LONG-TERM SAFETY STUDY OF TZIELD® (TEPLIZUMAB-MZWV) IN PATIENTS WITH STAGE 2 TYPE 1 DIABETES
J
Jamie Felton
What is the purpose of this study?The purpose of this research is to collect general information on patients with stage 2 type 1 diabetes (T1D) and further information on the long-term effects of TZIELD® in patients with Stage 2 T1D, treated as per standard of care. THIS STUDY IS ENROLLING BY …
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