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Found 715 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Pilot Study in the Treatment of Refractory Epstein-Barr Virus (EBV) Infection with Related Donor EBV Cytotoxic T-Lymphocytes in Children, Adolescents and Young Adult Recipients - NYMC 581

S
Scott Goebel, MD
1-79 years
All genders
Phase 2
Interventional
What is the purpose of this study?Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured withhe Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children,dolescents and young adults with refractory EBV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid …
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Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)

S
Scott Goebel, MD
1-79 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Captureystem will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) or with primary …
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Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

S
Scott Coven
1-25 years
All genders
Phase 1
Interventional
What is the purpose of this study?This phase I trial studies the side effects and best dose of trametinib and everolimus ing pediatric and young adult patients with gliomas that have come back (recurrent). Trametinib acts by targeting a protein in cells called MEK and disrupting tumor growth.verolimus is a …
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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

B
Brian Weiss
12-30 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits ofgavivint in treating patients with solid tumors that has come back (recurrent) or does notd to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help …
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Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

S
Scott Goebel, MD
1-79 years
All genders
Phase 2
Interventional
What is the purpose of this study?Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with theyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in inhildren, adolescents and young adults with refractory ADV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) ord organ …
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Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)

S
Scott Goebel, MD
1-30 years
All genders
Phase 2
Interventional
What is the purpose of this study?CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ …
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A Phase 2 Trial of Chemotherapy followed by Response-Based Whole Ventricular & Spinal Canal Irradiation (WVSCI) for Patients with Localized Non-Germinomatous Central Nervous System Germ Cell Tumor.

S
Sandeep Batra, MD
3-30 years
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients withgerminomatous germ cell tumors (NGGCT) that have not spread to other parts of the brainbody (localized). This study has …
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Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

J
Jenny Belsky, DO
2 years and older
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effects of nivolumab with chemo-immunotherapy versushemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with …
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A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

S
Sandeep Batra, MD
50 years and younger
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the safety and effect of adding vinorelbine to vincristine, dactinomycin, and cyclophosphamide (VAC) for the treatment of patients with high riskhabdomyosarcoma (RMS). High risk refers to cancer that is likely to recur (come back) afterd to other parts of …
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Trastuzumab Deruxtecan for the Treatment of HER2+ Newly Diagnosed or Recurrent Osteosarcoma

B
Brian Weiss
12-39 years
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies the effects of trastuzumab deruxtecan in treating patients with HER2 positive osteosarcoma that is newly diagnosed or has come back (recurrent). Trastuzumab deruxtecan is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug called deruxtecan. Trastuzumab attaches to …
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