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Found 743 results
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Randomized, Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL Pre-filled Syringe With 1 mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
D
Domenick Zero, DDS, MS
What is the purpose of this study?The purpose of this study is to demonstrate the comparability of ianalumab exposure following the sub-cutaneous (s.c.) administration of one injection of 300 mg/2 mL auto-injector (AI) versus two injections of 150 mg/1 mL pre-filled syringe (PFS), and to evaluate the safety and tolerability …
A Multi-Center, Prospective, Longitudinal, Study Evaluating Immunologic, Inflammatory, and Laboratory Parameters Associated With Long-Term Palynziq® (Pegvaliase) Treatment in Subjects With Phenylketonuria (PKU) in the United States
M
Melissa Lah, MD
This is a 10-year multi-center, prospective, longitudinal, single arm study evaluating immunologic, inflammatory and laboratory parameters associated with long-term Palynziq treatment in subjects with phenylketonuria (PKU) in the United States (US). Subjects in the US for whom a clinical decision has been made that they will receive pegvaliase to treat …
An Interventional Efficacy and Safety Phase 3 Double-blind 2-arm Study to Investigate IV Followed by Oral Fosmanogepix Compared With IV Caspofungin Followed by Oral Fluconazole in Adult Participants With Candidemia and/or Invasive Candidiasis
N
Nicolas Barros, MD
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemia and/or invasive candidiasis, a life-threatening fungal infection caused by several species of yeast called Candida.The study is seeking patients who have a diagnosis of …
Advanced Cardiac Therapies Improving Outcomes Network to Improve the Health of Pediatric and Congenital Heart Disease Patients with Heart Failure
J
John Parent, MD
What is the purpose of this study?Our goal is to partner with patients who have heart failure and their families to achieve improved outcomes and quality of life. In addition, the network will provide an ideal platform for clinical, translational, and comparative effectiveness research.THIS STUDY IS ENROLLING BY INVITATION ONLY …
Characterization of the neural correlates of anesthetic-induced intraoperative dream states using stereoelectroencephalography.
D
David Purger
What is the purpose of this study?Dreams experienced during emergence from anesthesia have been associated with improvement in trauma-related psychiatric disorders. This study aims to characterize the brain network activity patterns associated with anesthetic-induced intraoperative dreams to gain insight into the underlying mechanisms of the phenomenon and its potential therapeutic …
The Effect of Lower Extremity Fracture Non-union on Gait
Y
Yohan Jang
What is the purpose of this study?This study aims to understand how lower leg fractures that don’t heal properly affect walking speed. It also seeks to verify if the Apple iPhone can accurately measure walking speed and other gait characteristics in people with these injuries.THIS STUDY IS ENROLLING BY INVITATION …
A PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, TREAT-THROUGH STUDY TO ASSESS THE EFFICACY AND SAFETY OF INDUCTION AND MAINTENANCE THERAPY WITH RO7790121 IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN'S DISEASE
M
Monika Fischer, MD
The purpose of this study is to assess the efficacy and safety of RO7790121 (formerly PF-06480605 and RVT-3101) in patients with moderately to severely active Crohn's disease (CD). RO7790121 is a fully human neutralizing immunoglobulin G monoclonal antibody (mAb) against tumor necrosis factor-like ligand 1A (TL1A). TL1A plays a central …
Application of Cellie Coping Kits in Pediatric Patients with Eosinophilic Esophagitis (EoE)
P
Paroma Bose, MD
What is the purpose of this study?The aim of this study is to measure the efficacy of the Cellie Coping Kit in pediatric patients with EoE. Furthermore, an additional aim is to determine if there is variation in the kits efficacy among patients being treated with diet elimination versus medications …
Indiana University Orthopaedic Sports Medicine Cohort Data Repository
B
Bryan Saltzman
The purpose of this study is to prospectively collect patient-reported outcome measures, biospecimens, and imaging on patients who undergo orthopaedic sports medicine surgeries. These data will be used to determine predictors and correlates of joint damage (i.e. cartilage, ligament or meniscal damage, as well as osteoarthritis and arthrofibrosis) on the …
Validation of Early Prognostic Data for Recovery Outcome after Stroke for Future, Higher Yield Trials
A
Ann Marie Jones
What is the purpose of this study?Currently, 7 million US stroke survivors have significant disability, more than half with residual motor deficits. Motor function, particularly of the upper extremity (UE), is critical for regaining independence after stroke. VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute …
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