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Found 715 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

S
Sandeep Batra, MD
2-25 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial investigates the best dose of vinblastine in combination withumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinibg children and young adults with low-grade glioma (a common type of brain) that has come back after prior treatment (recurrent) …
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Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation

S
Sandeep Batra, MD
24-18 years
All genders
Phase 2
Interventional
What is the purpose of this study?This trial studies the side effects of enasidenib and to see how well it works in treatingwith acute myeloid leukemia that has come back after treatment (relapsed) or has been difficult to treat with chemotherapy (refractory). Patients must also have a specific genetic change, …
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Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

N
Nabil Adra, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?This is an open label randomized phase II trial of maintenance oral etoposide vs. observationwith relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood(PBSCT).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened …
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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

M
Marissa Just
30 years and younger
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies how well combination chemotherapy works in treating patients withwly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in chemotherapy regimens suchH-3 (vincristine, doxorubicin, cyclophosphamide, carboplatin, etoposide, …
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Improving Lung Cancer Screening Rates

F
Francesca Duncan
50-80 years
All genders
Interventional
Lung cancer is the leading cause of cancer death in the United States among men and women. Lung cancer screening using low-dose CT scan can identify lung cancer at its’ earliest stage when more curative treatment options are available. However, only 4-6% of people eligible for lung cancer screening get …
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A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

S
Sandeep Batra, MD
2-21 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600Eutation and is not …
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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

S
Sandeep Batra, MD
1-25 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with …
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Dual-Site Stimulation for OSA (BOOST Study)

N
Noah Parker, MD
22-100 years
All genders
Interventional
What is this study about?The objective of this early feasibility study is to assess the safety of chronic dual site stimulation by adding infrahyoid stimulation in non-responding patients with pre-existing single-site hypoglossal nerve stimulation.This study will also assess whether the secondary Inspire System can achieve the intended purpose of causing …
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Phase 1b/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy

J
Justin Sims, MD
18-100 years
All genders
Phase 3
Interventional
What is this study about?This study aims to determine the safety, pharmacokinetics (PK) and recommended Phase 3 dose (RP3D) of RYZ101 in Part 1, and the safety, efficacy, and PK of RYZ101 compared with investigator-selected standard of care (SoC) therapy in Part 2 in subjects with inoperable, advanced, well-differentiated, somatostatin …
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A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 (bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON)

R
Ryan Boente
40-100 years
All genders
Interventional
What is this study about?To characterize the effect of bexotrgrast versus placebo on the change in forced vital capacity (FVC) in participants with idiopathic pulmonarybrosis (IPF) at Week 52.
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