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Found 742 results
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis (Shasta-5 Study)
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Mark Gromski, MD
This study will evaluate the efficacy and safety of plozasiran in approximately 140 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events not attributed to other etiologies, with at least one occurring within the last 12 months prior to screening. THIS STUDY IS …
A Post-Authorization Safety Study (Pass) to Assess Long-Term Safety in Patients with Pompe Disease Treated with Avalglucosidase Alfa in the Real-World Setting: the Savant (Safety Assessment of Avalglucosidase Alfa as a Novel Treatment) Study
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Melissa Lah, MD
This is an observational study with the aim of gathering safety information on avalglucosidase alfa treatment for Pompe disease. We will collect long term safety data and evaluate the important identified risk of infusion associated reactions (IARs) including hypersensitivity and anaphylactic reactions and the important potential risk of medication errors …
A Phase 3, Double-Blind, Placebo-Controlled, Randomized Study to Assess the Safety of Epicutaneous Immunotherapy With Dbv712 250 Mcg in 1-Through 3-Year-Old Children With Peanut Allergy
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Girish Vitalpur, MD
The primary objective of this study is to assess the 6-month safety of DBV712 250 micrograms (mcg) in subjects 1 through 3 years of age with peanut allergy.THIS STUDY IS ENROLLING BY INVITATION ONLY
Integrated Therapies for Alcohol Use in Alcohol-Associated Liver Disease
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Raj Vuppalanchi, MD
To determine whether interventions directed to treat AUD integrated with sAH therapies will improve a composite endpoint of alcohol and liver-related events at 6 months compared to usual care for AUD (primary endpoint)To compare 90-day survival in patients receiving F-652 with those receiving up to 28 days of prednisone using …
Comparison Study of the Xpert Tap Panel Test Between Trained and Untrained Users on the Genexpert Edge X System
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Thomas E. Davis
The purpose of the study is to develop a new diagnostic test that could detect if a person is infected with tularemia, anthrax, and/or plague (acronym: TAP).THIS STUDY IS ENROLLING BY INVITATION ONLY - Healthy individuals, via self-reporting, 14 years of age or older will be approached for inclusion in …
Inhaled Nitric Oxide (Ino) for Congenital Diaphragmatic Hernia (Cdh) - The "Nono Trial" - a Multi-Center, De-Implementation, Stepped-Wedge, Cluster-Randomized Trial Within an Established Collaborative
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Brian Gray, MD
The purpose of this study is to Determine if deimplementation of iNO in the post-natal resuscitation/stabilization phase affects the composite outcome of ECLS use and/or mortality, as well as ECLS use, mortality, and/or oxygenation in CDH newborns and to establish the cost-effectiveness of deimplementing iNO as a therapy in the …
Phase Iii, Double-Blind, Randomized Placebo-Controlled Study to Evaluate the Effects of Dalcetrapib on Cardiovascular (Cv) Risk in a Genetically Defined Population With a Recent Acute Coronary Syndrome (Acs)
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Rolf Kreutz, MD
This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile. Subjects will provide informed consent before any study-specific procedures are performed. A separate informed consent will be allowed for an initial pre-screening genetic testing. Subjects meeting …
Pnoc031: Protocol for Embryonal Tumor With Multilayered Rosettes (Etmr)
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Scott Coven
This is an open-label, comprehensive, iterative investigation of evaluating the use of induction chemotherapy, high-dose chemotherapy, and focal radiation therapy in children with newly diagnosed Embryonal Tumor With Multilayered Rosettes (ETMR).PRIMARY OBJECTIVES I. To determine the six-month progression-free survival (PFS6) of participants with newly diagnosed, gross-totally resected, non-metastatic ETMR, treated …
Evaluation of the Effect of Acute Kidney Injury on Body Composition Among Preterm Infants. A Prospective Case-Control Observational Pilot Study
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Brianna Liberio
The purpose of this study is to assess the body composition and growth measurements at time of NICU discharge of preterm infants who experienced acute kidney injury during their hospitalization, and to compare this with matched controls who did not experience acute kidney injury.THIS STUDY IS ENROLLING BY INVITATION ONLY …
Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
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Jignesh Tailor
New data suggests that the current treatment for pediatric adamantinomatous craniopharyngioma (CPA) may not be as effective as it could be. Current treatment regimens for pediatric CPA are limited to surgery and radiation therapy. This pilot study seeks to identify biologically rational therapeutics for the medical treatment of adamantinomatous CPA …
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