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Found 716 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Evaluate the Efficacy and Safety of Anumigilimab in Patients with Hidradenitis Suppurativa Who Have Had an Inadequate Response to Anti-TNF Therapy

D
David Rosmarin
18-100 years
All genders
Phase 2
Interventional
Hidradenitis suppurativa (HS) is a painful skin condition with recurring lumps, abscesses, and tunnels that drain unpleasant fluids, significantly affecting quality of life.What is the purpose of this study?The primary objective of the study is to evaluate the efficacy of anumigilimab administered in Treatment Period A to subjects with moderate …
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A Phase 3, Randomized, Double-Blind, 52-Week, Placebo-Controlled,Efficacy and Safety Study of Povorcitinib in Participants With Nonsegmental Vitiligo (Selective Treatment of Oral Povorcitinib in Vitili)

D
David Rosmarin
18-75 years
All genders
Phase 3
Interventional
What is the purpose of this study?The purpose of this Study is to compare the safety and effects of povorcitinib or placebo on people with nonsegmental vitiligo.
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An open-label, phase II proof-of-concept study to evaluate the clinical efficacy and safety of tapinarof for adult patients with palmoplantar keratoderma

D
David Rosmarin
18-75 years
All genders
Phase 2
Interventional
What is the purpose of this study?This study is being done to find out how safe and how well the drug Tapinarof (VTAMA) works for stopping or treating palmoplantar keratoderma, which is a condition characterized by thickened skin on your palms and soles.  Tapinarof, used as a topical 1% cream, …
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A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA) (Rezolve AA)

D
David Rosmarin
18-70 years
All genders
Phase 1/2
Interventional
Why is this study being done?This study is being done to evaluate the efficacy (how well the drug works), and safety, of rezpegaldesleukin (REZPEG) at different dose levels, as compared to placebo, in adults with severe to very severe Alopecia Areata (AA), and to choose the best dose of REZPEG. …
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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

J
Jessica Parker Metter
18-100 years
Female
Phase 3
Interventional
What is the purpose of this study?The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with Physician's Choice of chemotherapy and bevacizumab in women diagnosed with platinum-resistant/refractory ovarian cancer …
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Using Circulating Tumor DNA to Personalize Duration of Consolidation Durvalumab

N
Nasser Hanna, MD
18-100 years
All genders
Phase 2
Interventional
What is the purpose of this study?This research aims to incorporate ctDNA analysis into clinical practice to individualize therapy in patients with stage III NSCLC by moving to a treatment-by-marker based approach (as opposed to treatment based on clinical or radiographic evidence of disease).THIS STUDY IS ENROLLING BY INVITATION ONLY …
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GammaTile and Stupp in Newly Diagnosed GBM (GESTALT)

M
Mitesh Shah, MD
18-100 years
All genders
Phase 4
Interventional
What is the purpose of this study?This study seeks to explore if GT, given its unique radiobiological and physical characteristics, may permit safe dose escalation and intensification and thereby provide a benefit to newly diagnosed GBM patients in terms of OS and LC when incorporated into the framework of the …
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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

S
Sandeep Batra, MD
12-21 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called …
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A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer (CAPTAIN)

S
Shadia Jalal, MD
40-80 years
Male
Interventional
What is the purpose of this study? The purpose of this research study is to: Test whether the TULSA Study Procedure preserves or improves your quality of life (urinary, bowel and sexual functions) at 12 months post-study treatment compared to standard of care (radical prostatectomy). Test how many subjects who …
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Phase II Trial of Carboplatin +/- Tocilizumab for Metastatic Triple Negative and ER-low Breast Cancers

K
Kathy Miller, MD
18 years and older
All genders
Phase 2
Interventional
What is the purpose of this study?This is a randomized Phase II study of carboplatin monotherapy vs. carboplatin combined with tocilizumab in in Black and non-Black patients with metastatic triple negative or ER low breast cancer. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients …
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