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Found 165 Cancer trials

A listing of Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

HeadStart4: Newly Diagnosed Children (

D
Daniel Runco, MD
All genders
This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free survival (EFS) and overall survival (OS).

A PHASE 1/2, OPEN LABEL DOSE-ESCALATION AND EXPANSION TRIAL OF NKT2152, AN ORALLY ADMINISTERED HIF2 ALPHA INHIBITOR, TO INVESTIGATE SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS AND CLINICAL ACTIVITY IN PATIENTS WITH ADVANCED CLEAR CELL RENAL CELL CARCINOMA

T
Theodore Logan, MD
18-100 years
All genders
Interventional
This is a Phase 1/2 open label multicenter study of NKT2152. Phase 1 is a first in human (FIH) dose escalation study in patients aged 18 years or older with clear cell renal carcinoma (ccRCC) who have exhausted available standard therapy as determined by the investigator. Phase 1 is designed …

A Non-randomized Open-label Multi-center Phase I/II Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Copanlisib in Pediatric Patients With Relapsed/Refractory Solid Tumors or Lymphoma

J
James Croop, MD, PhD
1-21 years
All genders
This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy.

Phase III Randomized Study of Crenolanib versus Midostaurin Administered Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed Subjects with FLT3 Mutated Acute Myeloid Leukemia

S
S. Hamid Sayer, MD
18-60 years
All genders
This is a phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation.

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

S
Sandeep Batra, MD
All genders
Phase 3
Interventional
Rhabdomyosarcoma is a type of cancer that occurs in the soft tissues in the body. This phaseutcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristined dactinomycin (VA) and examines the use of centralized molecular risk stratification inhe …

A multicenter safety study of unlicensed investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients

S
Sherif Farag, MD
All genders
The purpose of this study is to evaluate the safety of administration of the investigational cord blood units by carefully documenting all infusion-related problems.

A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL)

S
Sandeep Batra, MD
1-30 years
All genders
The purpose of this study is to look at iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma.

AGCT1531: A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

S
Sandeep Batra, MD
All genders
The purpose of this study is to compare the effects good and/or bad of carboplatin with cisplatin on people with standard risk germ cell tumors to find out which is better.

A Phase 3 Trial of Antibody hu3F8 and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in High-Risk Neuroblastoma Patients with Primary or Secondary Refractory Osteomedullary Disease

T
Terry Vik, MD
1-100 years
All genders
The purpose of this research trial is to find out about the treatment effects of an antibody called humanized 3F8 (hu3F8).

A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

A
April Rahrig, MD
3-30 years
All genders
Phase 1/2
Interventional
To determine the recommended phase 2 dose (RP2D) of vorinostat in children, adolescents and young adults following allogeneic HCT. Eligibility:A prospective patient for allogeneic BMT for malignant hematologic conditions Ages 3-30 Diagnoses include:Acute Leukemia in remissionChronic Myeologenous Leukemia (CML)  Myelodysplastic syndrome (MDS) Additonal criteria must be met based on determination …
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