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Found 165 Cancer trials

A listing of Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Phase II Trial of Panitumumab Nivolumab and Ipilimumab for KRAS/NRAS/BRAF Wild-type MSS Refractory Metastatic Colorectal Adenocarcinoma

P
Patrick Loehrer, MD
18-100 years
All genders
The purpose of this research study is to learn more about the safety and anti-cancer activity of a 3-drug combination therapy involving antibodies nivolumab, ipilimumab and panitumumab.

Circulating Tumor Cells (CTC) in Lung Cancer

J
Jessica MacLean
S
Shadia Jalal, MD
All genders
The purpose of this study is to examine rare cells called circulating tumor cells that are present in a person's blood when they have lung cancer to see if there is a relationship between a person's cancer symptoms and the number and characteristics of those cells at various times before …

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

R
Richard Zellars, MD
40-100 years
Female
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy.

Translational Breast Cancer Research Consortium Biospecimen & Outcomes Repository

K
Kathy Miller, MD
18-100 years
Female
The purpose of this study is to develop a repository of clinical data and outcomes, with and without corresponding specimens from individuals who have participated in TBCRC studies.

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer (PALAVY)

K
Kathy Miller, MD
18-100 years
All genders
Phase 2
Interventional
This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who areund to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgeryd standard adjuvant therapy.

PSMA-PET to Guide Prostatectomy

C
Clinton Bahler, MD
40-80 years
Male
Phase 2/3
Interventional
In this study, 288 patients will be randomized 1:1 to either having only the standard of careRI prior to surgery versus having the standard of care MRI and the PSMA PET scan. PET (andRI) findings will be validated against whole mount pathology. Pre-surgical imaging findings will also be evaluated in …

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

N
Nabil Adra, MD
18-100 years
Male
Phase 1
Interventional
Evaluate the safety and tolerability of AMG 509 in adult participants and determine theum tolerated dose (MTD) or recommended phase 2 dose (RP2D).

International validation of a patient reported experience measure for GI endoscopy

D
Douglas Rex, MD
18-100 years
All genders
Understanding patient experience at colonoscopy is important for quality of endoscopic practice and to maximize participation in screening programs for colorectal cancer.  The Newcastle ENDOPREM™ has been tested and validated in the UK. It is important to study whether this tool is valid when applied in different languages and different …

Phase II trial of retroperitoneal lymph node dissection as first-line treatment for testicular seminoma with isolated retroperitoneal disease (1-2cm)

C
Clint Cary, MD
16-100 years
All genders
The purpose of this study is to evaluate the safety and effectiveness of Retroperitoneal Lymph Node Dissection (RPLND) as a treatment option for seminoma that has gone to the lymph nodes in the retroperitoneum.

Randomized Phase II Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479 NSC# 750008) to Multiagent Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma

S
Sandeep Batra, MD
All genders
This randomized phase II trial studies how well combination chemotherapy with or without ganitumab works in treating patients with newly diagnosed Ewing sarcoma that has spread to other parts of the body.
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