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Found 163 Cancer trials

A listing of Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Enzastaurin Plus R-CHOP Versus R-CHOP in Treatment-Naive Subjects With High-Risk Diffuse Large B-Cell Lymphoma Who Possess the Novel Genomic Biomarker DGM1?

M
Michael Robertson, MD
18-100 years
All genders
The purpose of this study is to compare the effect of RCHOP/enzastaurin versus R-CHOP on overall survival (OS) in treatment-naive, high-risk subjects with Diffuse Large B-Cell Lymphoma (DLBCL) who possess the DGM1 biomarker.
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A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) with Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed and Refractory Hematologic Malignancies

N
Naoyuki Saito, MD
18-65 years
All genders
The purposes of this study are to: (1) find the most effective dose of a new type of radiation therapy called total marrow irradiation (TMI) that will be given with the conditioning chemotherapy, fludarabine, to prepare patients for allogeneic hematopoietic stem cell transplantation (Allo-HSCT); and (2) see if utilization of …
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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA) (DEBRA)

N
Naoyuki Saito, MD
50-70 years
All genders
Phase 3
Interventional
This Phase III Trial evaluates whether breast conservation surgery and endocrine therapyults in a non-inferior rate of invasive or non-invasive ipsilateral breast tumorurrence (IBTR) compared to breast conservation with breast radiation and endocrineherapy.
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Pediatric Thyroid Registry

T
Troy Markel, MD
21 years and younger
All genders
This study creates a registry to understand treatments for thyroid nodules and differentiated thyroid cancer in children.
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Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases in Children and Young Adults With Refractory Sarcomas Wilms Tumor and Other Rare Tumors

S
Sandeep Batra, MD
2-30 years
All genders
This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed.
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Evaluation of an Exercise intervention for Vincristine induced peripheral neuropathy in pediatric cancer patients

J
Jamie Renbarger, MD
100 years and younger
All genders
The purpose of this study is to evaluate the feasibility and acceptability of exercise as an intervention for vincristine-induced peripheral neuropathy in pediatric patients with ALL.
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A Study of miRNA 371 in Patients With Germ Cell Tumors

N
Nabil Adra, MD
18 years and older
All genders
Observational
This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predicthe chance of cancer returning in patients with germ cell cancers. Studying samples of bloodwith germ cell cancers in the laboratory may help doctors predict how likelyhe cancer will come back.
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A Randomized Phase II Trial of Brentuximab Vedotin (SGN35 NSC# 749710) or Crizotinib (NSC#749005 Commercially Labeled) in Combination With Chemotherapy for Newly Diagnosed Patients With Anaplastic Large Cell Lymphoma (ALCL)

S
Sandeep Batra, MD
21 years and younger
All genders
This partially randomized phase II trial studies how well brentuximab vedotin or crizotinib and combination chemotherapy works in treating patients with newly diagnosed stage II-IV anaplastic large cell lymphoma.
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A Phase 1 Study Of Ramucirumab a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 (VEGFR-2) Receptor in Children With Refractory Solid Tumors Including CNS Tumors

J
James Croop, MD, PhD
1-21 years
All genders
The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children with recurrent or refractory solid tumors including central nervous system (CNS) tumors.
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Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

L
Lisa Landrum, MD, PhD, MS
18 years and older
Female
Phase 3
Interventional
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary,ube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount ofgen made by the body which in turn may stop the growth …
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