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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Palliative Care Approaches for Acute Myeloid Leukemia

L
Larry Cripe, MD
18 years - 100 years
All genders
This study investigates the impact of different palliative care strategies on patients with acute myeloid leukemia (AML). Acute myeloid leukemia is a type of cancer that affects the blood and bone marrow. It is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow …
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OSTEOPATHIC MEDICINE SUPPORTIVE CARE IN PEDIATRIC

J
Jenny Belsky, DO
2 years - 30 years
All genders
What is the purpose of this study?The purpose of this study is to find compare therapy side effects with a treatment called osteopathic manipulative treatment to standard of care medicines without osteopathic manipulative treatment. Osteopathic medicine is a distinct form of medical practice that offers the added benefit of hands-on …
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The Rare Brain Tumour Consortium Registry and Biobank

S
Scott Coven
18 years or below
All genders
What is the purpose of this study?The Biobank being created by this study is located at the Hospital for Sick Children in Toronto, Canada and is a research registry that collects biological samples and medical information from individuals in participating centers around the world. The purpose of this registry is …
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Creation of specimen biorepository and analysis of transcriptome and metabolome as potential mechanism in intestinal failure associated liver disease in neonate

K
Katie Huff
100 years or below
All genders
We will build a biorepository of blood and urine samples correlated with clinical data in neonates receiving parenteral nutrition in order to study IFALD
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Research Study on Safety and Effects of an Investigational Medication for Advanced Solid Tumors

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
This study investigates the safety and effects of an investigational medication in people with advanced solid tumors. Advanced solid tumors are cancers that have spread and do not respond well to regular treatments. The purpose of this study is to find out how safe the medication is, how the body …
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Improving sleep in acute respiratory failure survivors

B
Babar Khan, MD
18 years - 100 years
All genders
The purpose of this study is to evaluate the impact of a sleep deprivation and disruption on quality of life of acute respiratory failure ICU survivors using sleep actigraphy. Sleep actigraphy is a method of measuring sleep parameters and average motor activity over a period of days to weeks using …
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GRNDaD

S
Seethal Jacob, MD
12 years - 26 years
All genders
The primary objective of this research is to create a multi-site registry to collect longitudinal data on a well-documented phenotypic cohort of people with sickle cell disease (SCD) in order to examine risk factors for end organ disease and better understand how clinical characteristics predict outcomes.
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Pilot Pharmacokinetic Study of VAL-413 (Orotecan) in Patients with Recurrent Pediatric Solid Tumors

K
Kyle William Jackson
1 years - 30 years
All genders
Phase 2
What is the purpose of this study?To establish the recommended phase II dose of a flavored preparation of orally administered irinotecan (VAL-413) when given in combination with temozolomide for five consecutive days. To characterize and compare the pharmacokinetic profiles of VAL-413 and conventional irinotecan given orally To evaluate the palatability …
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A Long-term Multicenter Prospective Observational Study Evaluating the Comparative Effectiveness and Safety of Sarepta Gene Transfer Therapy vs. Standard of Care in Participants with Duchenne Muscular Dystrophy under Conditions of Routine Clinical Practice

M
Marcia Felker, MD
4 years - 5 years
Male
Phase 4
Observational
What is the purpose of this study?This is a multicenter, prospective, observational Phase 4 study in the United States. The study is designed to collect both medical history and prospective data on Duchenne muscular dystrophy (DMD) treatment outcomes in participants receiving delandistrogene moxeparvovec as part of clinical care, compared to …
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A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.

K
Kathryn Nevel
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?The brain is protected from any toxic or inflammatory molecule by the blood-brain barrier (BBB). This physical barrier is located at the level of the blood vessel walls. Because of these barrier properties, the blood vessels are also impermeable to the passage of therapeutic …
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