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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on Investigational Cord Blood Units

J
Jodi Skiles
100 years or below
All genders
This study investigates the safety of using investigational cord blood units (CBUs) for hematopoietic stem cell transplants in both children and adults. Hematopoietic stem cells are important for creating new blood cells. The study will carefully look at any problems that happen during or after the infusion of these CBUs.Participants …
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Study on Sweat Chloride Levels in Cystic Fibrosis Patients Using Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators

D
Don Sanders, MD
4 months or above
All genders
This study investigates how treatments for Cystic Fibrosis affect sweat chloride levels. Cystic Fibrosis is a condition that causes thick mucus to build up in the lungs and other parts of the body. This study is looking at people who are taking certain medicines called CFTR modulators, which help improve …
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Translational Breast Cancer Research Consortium Biospecimen & Outcomes Repository

K
Kathy Miller, MD
18 years - 100 years
Female
The purpose of this study is to develop a repository of clinical data and outcomes, with and without corresponding specimens from individuals who have participated in TBCRC studies.
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Study on Access to Birth Control and Health of Mothers and Babies

J
Jeffrey Peipert, MD
18 years - 44 years
Accepts healthy volunteer
Female
This study investigates how access to comprehensive family planning and long-acting reversible contraceptives (LARC) can impact maternal and infant health outcomes. The study is being conducted in Marion County and aims to expand statewide, focusing on providing patient-centered counseling and same-day access to affordable contraception for women.Participants will complete a …
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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE SAFETY, EFFICACY, AND PHARMACOKINETICS OF BUDESONIDE EXTENDED-RELEASE TABLETS ADMINISTERED ONCE DAILY IN PEDIATRIC SUBJECTS AGED 5 TO 17 YEARS WITH ACTIVE, MILD TO MODERATE ULCERATIVE COLITIS

M
Marian Pfefferkorn
5 years - 17 years
All genders
Interventional
The primary objective of this study is to evaluate the efficacy and safety of a low and a high dose of budesonide extended-release tablets in pediatric subjects with active, mild to moderate UC.During the study, partiicpants (or their parent / guardian, as appropriate) will be required to document theirdisease symptoms …
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Delirium and Neuropsychological Recovery Among Emergency General Surgery Survivors

M
Malaz Boustani, MD
65 years or above
All genders
Interventional
This study will evaluate the usefulness of the Emergency General Surgery (EGS) Delirium Recovery Model. It is hypothesized that the cognitive, physical and psychological recovery ofder EGS delirium survivors will be improved through the use of the EGS Delirium Recoverydel. Participants can expect to be on the study for 18 …
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Study of Investigational Treatment for Slow-Growing Brain Tumors in Children and Young Adults

S
Sandeep Batra, MD
2 years - 21 years
All genders
Phase 3
Interventional
This study investigates treatment options for children and young adults with low-grade glioma (LGG), a type of brain tumor. The purpose of this study is to compare the effects of an investigational medication with standard chemotherapy treatments, carboplatin and vincristine, in patients who do not have a specific genetic mutation …
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Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

J
Jodi Skiles
All genders
Observational
The primary purpose of the Research Sample Repository is to make blood samples available forh studies related to histocompatibility and hematopoietic cell transplantation (HCT)her cellular therapy. Representatives of participating centers and investigators or research groups may requesth samples contained in the Research Sample Repository for the purpose ofducting research including: …
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A phase 1b/2, multicenter, adaptive, double-blind, randomized, placebo-controlled study to assess the safety, tolerability, immunogenicity, and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in adults with Down syndrome (ABATE)

J
Jill Fostad
35 years - 50 years
All genders
Phase 1/2
Interventional
What is this study about?The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndrome.This phase 1b/2 study will be in 2 parts. Study Part 1 will involve subjects with prodromal …
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A Phase 1 Trial of Targeted Immunotherapy with Daratumumab Following Myeloablative Total Body Irradiation (TBI)-Based Conditioning and Allogeneic Hematopoietic Cell Transplantation in Children, Adolescents and Young Adults with High-Risk T-Cell Acute Lymphoblastic Leukemia and Lymphoma

J
Jodi Skiles
1 years - 39 years
All genders
Phase 1
What is the purpose of this study?A Phase I trial to determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high risk T-cell acute lymphoblastic leukemia (T-ALL) or …
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