Loading...
Found 594 results for IU Health Enterprise System
A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Enhancing shared decision-making to prompt and guide individualized care for people with Alzheimer's Disease and Diabetes
A
April Savoy
For patients and caregivers, ADRD-DM presents unique challenges for detecting and preventing hypoglycemia.Individualized care for people with ADRD-DM should be based on patient and caregiver goals along with patients’ cognitive and physical abilities, reported outcomes, and hypoglycemia risk, based largely on prior hypoglycemic events. Providing details of hypoglycemic events and risks …
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
S
Sandeep Batra, MD
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600Eutation and is not associated with systemic neurofibromatosis type 1. …
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
A
Anthony Ross
This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a …
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)
J
Jared Brosch, MD
What is the purpose of this study?To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.THIS STUDY IS …
Optimizing Cirrhosis Emergency Care
A
Archita Desai, MD
Within our IU health system, utilizing retrospective data we developed a clinical decision instrument based on ED visits, named it as Cirrhosis Risk Instrument for Stratifying Post Emergency Department mortality (CRISPE) tool. This tool was designed to identify predictors of 14-day and 30-day mortality in individuals with cirrhosis. However, given …
A Phase 2 Study of Mutant-Selective Pi3Kα Inhibitor, Rly-2608, in Adults and Children with Pik3Ca Related Overgrowth Spectrum and Malformations Driven by Pik3Ca Mutation
R
Rachael Schulte
This is a 3-part Phase 2 randomized study evaluating the safety and efficacy of the mutant-selective PI3Kα inhibitor, RLY-2608, in adults and children with PIK3CA Related Overgrowth Spectrum (PROS) and malformations driven by PIK3CA mutation. THIS STUDY IS ENROLLING BY INVITATION ONLY
Molecular Analysis of Factors Involved in Benign Reproductive Tract Diseases
S
Shannon Hawkins
What is the purpose of this study?The purpose of this study is to collect female reproductive tract tissues to investigate the key molecular events regulating endometriosis. Our central hypothesis is that by using well-characterized tissues, we can create novel models to improve treatments for endometriosis. THIS STUDY IS ENROLLING BY INVITATION …
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma
S
Sandeep Batra, MD
What is the purpose of this study?Rhabdomyosarcoma is a type of cancer that occurs in the soft tissues in the body. This phaseutcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristined dactinomycin (VA) and examines the use …
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
S
Sandeep Batra, MD
What is the purpose of this study?This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acuteyeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop …
Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical Trial
T
Tony Navarrete
Cardiac-resynchronization therapy (CRT) is a type of heart failure (HF) treatment that improves the way your heart works, improves your ability to exercise, reduces hospitalization, and lengthens your lifespan. CRT can be delivered by pacing in one of two different configurations: biventricular pacing (BiVP) or pacing at a place called …
Please choose between Voice or SMS based delivery of verification code
or