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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Testing the Addition of Chemotherapy Drug, Cisplatin, to Usual Radiation Therapy for Patients with Head and Neck Cancer

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 2
Interventional
The purpose of this study is to compare two treatment approaches that are currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone. A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin.
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TArgeting Type 1 Diabetes Using POLyamines (TADPOL) (TADPOL)

E
Emily Sims, MD
6 years - 40 years
All genders
Phase 2
Interventional
The goal of this clinical trial is to test a drug known as DFMO in people with Type 1 Diabetes (T1D). The main question[s] it aims to answer are:Does it reduce stress on the cells that make insulin?Does it preserve what is left of the body's insulin production? Participants will …
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A Protocol for Children and Young Adults Diagnosed with a Central Nervous System (CNS) Tumor to Assess Cognitive, Quality of Life (QOL), and Comprehensive Effects of Therapies

S
Scott Coven
39 years or below
All genders
What is the purpose of this study?To longitudinally assess cognitive outcomes using an a neurocognitive screening battery in children and young adults diagnosed with a CNS tumor. To longitudinally assess the impact of specific therapies on the QOL in children and young adults diagnosed with a CNS tumor.To longitudinally assess …
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Investigational Treatment for a Type of White Blood Cell Disease

A
Anthony Ross
180 days - 22 years
All genders
Phase 2
Interventional
This study investigates an investigational medication for treating Langerhans cell histiocytosis (LCH), a disease where the body makes too many immature Langerhans cells, a type of white blood cell. These cells can build up and form tumors in organs like bones, skin, and lungs, causing damage. The purpose of the …
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A multicenter, single-arm, pivotal study to evaluate the safety and efficacy of the CGuard Prime carotid stent system (80cm) used in conjunction with the FDA-cleared ENROUTE Transcarotid Neuroprotection System (NPS) in patients undergoing carotid artery stenting via the Transcarotid Artery Revascularization (TCAR) approach.

R
Raghu Motaganahalli, MD
18 years - 79 years
All genders
Interventional
What is the purpose of this study?The objective of this study is to evaluate acute device and technical success of the CGuard Prime™ Carotid Stent System (80cm) when used in conjunction with the Enroute NPS during Transcarotid Artery Revascularization procedures in the treatment of carotid artery stenosis in spatients at …
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Total Shoulder Arthroplasty Multi-Center Registry study

M
Mark Dillon
18 years - 100 years
All genders
Observational
What is the purpose of this study?This study is an ongoing, non-randomized, multi-center, prospective registry utilizing primary or revision shoulder arthroplasty implants.  Subjects will be treated according to standard of care at each center. The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic …
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Comparing Optimal Step-down Therapy for Children with Invasive MRSA Trimethoprim-Sulfamethoxazole vs. Clindamycin for the Treatment of Children with Invasive MRSA Infections

J
James Wood, MD
60 days - 80 years
All genders
Interventional
What is the purpose of this study?This is a comparative effectiveness study of two antibiotics typically prescribed in the clinical setting of pediatric patients with osteoarticular infections (OAI, including acute osteomyelitis and septic arthritis) and head and neck infections (HNIs) caused by methicillin resistant Staphylococcus aureus (MRSA).. The goal of …
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Study for Measuring Plasma Free Hemoglobin in ECMO and VAD Patients

M
Michelle Zimmerman, MD
100 years or below
All genders
Observational
This study investigates the validation of an investigational medical device for measuring plasma free hemoglobin in patients using ECMO or VAD life-support machines. Plasma free hemoglobin is a substance that indicates hemolysis, which is the breakdown of red blood cells. The purpose of this study is to ensure the device …
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Study on Investigational Medicine for Liver Disease

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 3
Interventional
This study investigates the safety and effectiveness of an investigational medication in people with compensated cirrhosis caused by NASH/MASH. Cirrhosis is a condition where the liver becomes scarred and cannot work properly. NASH/MASH stands for non-alcoholic steatohepatitis and metabolic dysfunction-associated steatohepatitis, which are liver diseases that cause inflammation and scarring.Participants …
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Investigating Safety of Investigational Medication for Irritable Bowel Syndrome with Constipation (IBS-C) in Children

E
Erik David Andrewski
6 years - 17 years
All genders
Interventional
This study investigates the safety and tolerability of an investigational medication for treating Irritable Bowel Syndrome with Constipation (IBS-C) in children aged 6 to less than 18 years. IBS-C is a condition where children experience stomach pain and difficulty in passing stools. The purpose of this study is to observe …
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581 - 590 of 645