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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study on Sacral Nerve Stimulation and Signal Recording

C
Charles Powell, MD
18 years or above
All genders
Interventional
This study investigates the collection of signals from the sacral nerve when it is stimulated. The sacral nerve is a part of the nervous system that can affect bladder and bowel function. The study uses special systems to collect signals from this nerve to better understand how the nerve works …
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A Phase I Study of Intra-Tumoral Injections of Ex Vivo Expanded Natural Killer Cells in Children and Young Adults With Recurrent or Progressive Supratentorial Malignant Brain Tumors

S
Scott Coven
1 years - 38 years
All genders
Phase 1
What is this study about?This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent) or that are growing, spreading, or getting …
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A Pivotal, Prospective, Open-label, Multi-center Study of Safety and Effectiveness of Cochlear Implantation in an Expanded Population of Adults With Bilateral Sensorineural Hearing Loss

R
Rick Nelson, MD
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This study aims to evaluate the safety and efficacy of cochlear implantation for adults with bilateral sensorineural hearing loss who currently do not meet the FDA-approved indications for cochlear implantation. Following cochlear implantation, participants will complete speech perception assessments and questionnaires over the course …
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A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis

N
Noel Dasgupta
18 years or above
All genders
Observational
What is the purpose of this study?MaesTTRo is an international, longitudinal, non-interventional study of adult patients with transthyretin (ATTR) amyloidosis. The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and …
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Study on Effects of Investigational for Refractory Metastatic Colorectal Cancer in Minority Populations

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 4
This study investigates the effects of an investigational medication on high blood pressure in patients with refractory metastatic colorectal cancer (mCRC) from minority groups, specifically Black/African American and Hispanic/Latino populations. High blood pressure, also known as hypertension, is when the force of blood against the artery walls is too high, …
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A 2-stage, Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus (LAVENDER)

D
David Rosmarin
18 years - 70 years
All genders
Phase 3
Interventional
What is the purpose of this study?This study aims to evaluate the efficacy and safety of subcutaneous (SC) anifrolumab versus placebo in adult participants with cutaneous lupus erythematosus (CLE).
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Investigating Sinonasal Therapy De-escalation in Cystic Fibrosis Patients on Investigational Therapy

E
Elisa Illing
18 years - 100 years
All genders
Interventional
This study investigates the effects of reducing sinonasal therapies in patients with cystic fibrosis who are on cystic fibrosis transmembrane regulator (CFTR) modulator therapy. Cystic fibrosis is a genetic disorder that affects the lungs and other organs, characterized by thick, sticky mucus that can clog airways and lead to respiratory …
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NF119: A Phase 2, Open-Label, Single Arm, Non-Controlled, Single-Stage Study to Evaluate the Safety and Effects of HLX-1502 in Patients with Plexiform Neurofibroma and Neurofibromatosis Type 1

S
Steven Rhodes
16 years or above
All genders
Phase 2
What is the purpose of this study?The trial will be an open label, single arm, phase 2 study in 20 participants. The study will assess the tolerability and efficacy of HLX-1502 in participants with NF1 16 years of age or older with progressive and/or symptomatic PN. THIS STUDY IS ENROLLING …
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Investigating the Safety and Effects of an Investigational Antibody-Drug Conjugate in Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This study investigates the safety and effects of an investigational antibody-drug conjugate in patients with advanced or metastatic solid tumors. The purpose is to understand how the investigational medication works in the body and its impact on tumors. Advanced or metastatic solid tumors are cancers that have spread beyond their …
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Study on Investigational Medication for Candidemia and Invasive Candidiasis

N
Nicolas Barros, MD
18 years - 100 years
All genders
Phase 3
Interventional
This study investigates the effects and safety of an investigational medication for treating candidemia and invasive candidiasis, which are serious fungal infections caused by Candida species. Candidemia is a bloodstream infection, while invasive candidiasis occurs when the infection spreads beyond the bloodstream to other parts of the body.Participants will receive …
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