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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Non-randomized Open-label Multi-center Phase I/II Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Copanlisib in Pediatric Patients With Relapsed/Refractory Solid Tumors or Lymphoma

J
James Croop, MD, PhD
1 years - 21 years
All genders
This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy.
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A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

N
Noel Dasgupta
18 years or above
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the safety and tolerability of extended dosing withwith hereditary transthyretin-mediated amyloid polyneuropathy (hATTR-PN).
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Clinical Pharmacokinetics of Labetalol in Pregnancy

S
Sara Quinney
18 years or above
Accepts healthy volunteer
Female
What is this study about?This study will determine how plasma concentrations of labetalol, a medication commonly used to treat hypertension in pregnancy, change during and after pregnancy and how this may impact antihypertensive therapy. The study will also evaluate exposure of fetus/neonate to labetalol through cord blood and breast milk. Study …
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Investigating the Addition of an Investigational Medication to Chemotherapy for Osteosarcoma

S
Sandeep Batra, MD
40 years or below
All genders
Phase 2/3
Interventional
This study investigates the use of an investigational medication, cabozantinib, in combination with standard chemotherapy for patients with newly diagnosed osteosarcoma. Osteosarcoma is a type of bone cancer that typically affects the long bones in the body. Cabozantinib is a kinase inhibitor, which means it works by blocking specific enzymes …
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A Phase 3 Randomized, Open-label Induction, Double-blind Maintenance, Parallel-group, Multicenter Protocol to Evaluate the Efficacy, Safety, and Pharmacokinetics, of Guselkumab in Pediatric Participants with Moderately to Severely Active Ulcerative Colitis

M
Marian Pfefferkorn
2 years - 17 years
All genders
Phase 3
Interventional
What is this study about?The purpose of this study is to evaluate the efficacy of guselkumab in pediatric participants with moderately to severely active ulcerative colitis at the end of maintenance therapy among participants who were induction responders.THIS STUDY IS ENROLLING BY INVITATION ONLY
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Master Screening and Reassessment Protocol (MSRP) for TierAdvancement in the NCI myeloMATCH Clinical Trials

R
Rita Assi
18 years - 100 years
All genders
What is the purpose of this study?This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific laboratory tests to help improve participants' ability to register to clinical trials throughout the course of their myeloid cancer (acute myeloid leukemia or myelodysplastic syndrome) treatment. This …
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Cold Snare Endoscopic Mucosal Resection of Duodenal Adenomas more than or equal to 10 mm: A prospective cohort study

J
John Guardiola
18 years - 100 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to evaluate the safety and effectiveness of Cold Snare Endoscopic Mucosal Resection (CS-EMR) for the removal of non-cancerous polyps that are located in the small bowel (duodenal) and are 10 millimeters or greater in size. The goal of this …
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A Randomized, Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL Pre-filled Syringe With 1 mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

D
Domenick Zero, DDS, MS
18 years - 70 years
All genders
Phase 2
Interventional
What is the purpose of this study?The purpose of this study is to demonstrate the comparability of ianalumab exposure following the sub-cutaneous (s.c.) administration of one injection of 300 mg/2 mL auto-injector (AI) versus two injections of 150 mg/1 mL pre-filled syringe (PFS), and to evaluate the safety and tolerability …
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Investigating the Safety of an Investigational Treatment for a Type of Cancer Affecting White Blood Cells

H
Huda Salman
18 years - 100 years
All genders
Phase 1
This study investigates the safety of an investigational treatment using special immune cells called CAR-T cells for people with certain B cell cancers. B cell malignancies are cancers that affect a type of white blood cell. The study includes participants whose cancer has returned or not responded to previous treatments. …
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Aromatherapy Use to Decrease Functional Nausea and Increase Quality of Life in Pediatric Patients Seen in a Quaternary Care Outpatient Disorder of Gut Brain Interaction Clinic

E
Erik David Andrewski
9 years - 18 years
All genders
Interventional
What is the purpose of this study?The purpose of this study is to determine if an outpatient population of pediatric patients with nausea related to a disorder of gut-brain interaction (DGBI) have decreased symptoms after use of aromatherapy (QueaseEase) as measured by the Nausea ProfileTHIS STUDY IS ENROLLING BY INVITATION …
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