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Found 594 results for IU Health Enterprise System
A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Equity Using Interventions for Pain and Depression (EQUIPD) - Phase 2
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Marianne Matthias
What is the purpose of this study?This is phase 2 of a two-phase project with the overarching goal of testing a decision aid paired with coaching sessions, tailored to Black patients with comorbid chronic pain and depression. The decision aid/coaching sessions are designed to help people learn more about other …
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Online study
Craniosynostosis Patient-Reported Outcomes Using the FACE-Q Scales: A Prospective Observational Study
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Katelyn Makar
What is the purpose of this study?Craniosynostosis can affect normal brain development by causing local or regional increases in intracranial pressure. The goals of surgery in the treatment of craniosynostosis are to improve the appearance and morphology of the skull and to prevent functional disturbances such as intracranial hypertension and …
Osteosarcoma Predisposition - Developing New Models to Study Pediatric Osteosarcoma Development
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Jennifer Ivanovich
What is the purpose of this study?In partnership with Indiana Biosciences Research Institute, we will develop new models to study pediatric osteosarcoma. We will invite children with Li-Fraumeni syndrome, hereditary retinoblastoma syndrome, or Rothmund-Thompson syndrome to participate. These three syndromes are associated with an increased risk to develop osteosarcoma. THIS STUDY …
Indiana Neurosciences Biorepository at Riley Hospital for Children
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Jignesh Tailor
The purpose of this study is to collect tissue, blood, and CSF in patients with all conditions affecting the brain and spinal cord, with the goal of developing a repository of biospecimen and clinical data for neurosurgical patients within IU Health. This may help us learn how certain conditions develop …
A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)
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Mateusz Opyrchal, MD, PhD
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
Transperitoneal vs Extraperitoneal Retroperitoneal Lymph Node Dissection: A Prospective Randomized Controlled Trial
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Timothy Masterson
We intend to compare an alternative way of performing cancer surgery for those who have testis cancer. This alternative technique is called extraperitoneal RPLND which has been published in retrospective studies. Its benefits, however, remain to be proved in a prospective study. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent …
A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators
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Don Sanders, MD
What is the purpose of this study?The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR …
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
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Kaustubh Limaye, MD
What is the purpose of this study?This is a research study to determine which treatment approach helps patients the most when recovering from their stroke. Right now there are two main approaches used by doctors: putting a stent or inflating a balloon at the blockage/narrowing of the artery in the …
The Effects of Adverse Childhood Experiences (ACEs) on Risk Factors During Pregnancy and Adverse Pregnancy Outcomes Utilizing the Philadelphia ACE Questionnaire
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Alissa Conklin
What is the purpose of this study?To assess adverse childhood experiences involving family-level and community-level adversity and the relationship between these experiences and risk factors in pregnancy as well as pregnancy outcomes.THIS STUDY IS ENROLLING BY INVITATION ONLY - All pregnant patients' charts seeking prenatal care at Coleman and PND …
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics Randomized Controlled Trial
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Don Sanders, MD
The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient pulmonary exacerbations (PEx) in the pediatric CF population.THIS STUDY IS ENROLLING BY INVITATION ONLY
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