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Found 594 results for iu-health-enterprise-system
A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Integrated Therapies for Alcohol Use in Alcohol-Associated Liver Disease
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Raj Vuppalanchi, MD
To determine whether interventions directed to treat AUD integrated with sAH therapies will improve a composite endpoint of alcohol and liver-related events at 6 months compared to usual care for AUD (primary endpoint)To compare 90-day survival in patients receiving F-652 with those receiving up to 28 days of prednisone using …
Assessment of Skeletal Maturity Biomarkers in the Gingival Crevicular Fluid of Orthodontic Patients
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Rishma Shah
The purpose of this study is to find a non-invasive technique of measuring growth hormone-related factors to provide a prediction of future growth of a patient. The study will investigate factors in the fluid residing between the teeth and gums, and correlate this with age, height, weight, and indicators on …
A Phase 2/3, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Inebilizumab In Participants With Autoimmune Hepatitis
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Craig Lammert, MD
This is a randomized, multicenter, double-blind, phase 2/3 study to evaluate the efficacy and safety of inebilizumab in participants with active AIH who are inadequatelyresponding and/or are intolerant to SOC. The main objectives of this trial are to evaluate the safety and tolerability of inebilizumab in participants with autoimmune hepatitis …
The Effect of Transcutaneous Vagal Nerve Stimulation on the Inflammatory Response to Spine Surgery
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Cristina Barboi
The purpose of the study is to determine the feasibility postoperative vagal nerve stimulation and measure the effect on the plasma inflammatory markers on postoperative days 1-3.THIS STUDY IS ENROLLING BY INVITATION ONLY - Recruitment and eligibility screening will occur through standard clinical pathways within the Department of Neurosurgery. Spine …
The Impact of Exercise on Skeletal Muscle Function in Lung Transplant Recipients
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Gary Long
Individuals post lung transplant suffer from significantly reduced exercise capacity. Physical rehabilitation (such as that carried out in COLTT) has previously been shown to improve aerobic endurance and muscle strength, both of which are associated with improved survival. Unfortunately, there is very little known about the mechanisms behind these improvements. …
Evaluation of Bone Matrix Differences in Adults and Elderly Patients
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David Stockwell
The goal of this pilot study is to evaluate remodeling of the bone matrix and cellular composition as people age. We plan to utilize 2.5-5 ml of bone autograft and 2 ml of bone marrow aspirate from patients undergoing spinal decompression and fusion surgery to compare bone matrix and bone …
Assessing Physical Activity in Pediatric Patients With Difficult to Treat Asthma
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Sam Averill
Kids and teens with asthma often get less physical activity than recommended, even though exercise can improve asthma symptoms, lung function, overall fitness, and mental health. But we don’t fully understand: • How active our own clinic’s patients actually are • What they think about exercise • What gets in the way • What …
Prospective Measurement of Normative Esophageal Distensibility Using EndoFLIP in Asymptomatic Children
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Brett Hoskins
Endoluminal functional lumen imaging probe (EndoFLIP) is a minimally invasive, novel device that aids in the diagnosis of esophageal disorders. EndoFLIP is increasingly utilized for assessing esophageal biomechanics, yet normative data for children are lacking. Due to developmental differences in compliance and luminal size, adult reference values are not generalizable …
Newborn Screen for Severe Combined Immunodeficiency (SCID) Database/Registry
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Jay Jin
The purpose of this project is to collect and analyze relevant clinical data from children who have been identified as having a positive newborn screen for severe combined immunodeficiency (SCID) in order to understand the most common causes of SCID in Indiana, identify important immune parameters, determine the safest prophylactic …
Indiana University GI Neuromuscular Pathology Prospective Registry
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John Wo, MD
What is the purpose of this study?The purpose of this study is to determine if ICC abnormalities of the stomach and proximal jejunum can be used as a biologic marker in predicting clinical outcome in patients undergoing surgical implantation of GES for severe gastroparesis. The primary aim is to determine …
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