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Found 594 results for iu-health-enterprise-system
A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)
A
Ankit Desai
What is the purpose of this study?The study will evaluate the efficacy and safety of chronic oral levosimendan compared with placebo in PH-HFpEF subjects. This subject population represents a large and growing group with no established therapies to treat their PVD and RV dysfunction. Levosimendan and its prolonged active metabolite, …
A Multicenter, Open-label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 Years Undergoing Cardiac Surgery
B
Brandon Tanner
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 to less than 6 years of age undergoing cardiac surgery, utilizing local infiltration analgesia (LIA). THIS STUDY IS ENROLLING BY INVITATION …
A Prospective, Single-Arm Multi-Center Study of the HARMONIC 700, 5 mm Diameter Shears with Advanced Hemostasis in Pediatric Surgical Procedures (General) and Adult Surgical Procedures (General, Gynecological, Urological, and Thoracic)
T
Troy Markel, MD
What is the purpose of this study?The main purpose of this study is to demonstrate acceptable performance and assess safety of the HARMONIC 700 Shears device in a post-market setting when used per the instructions for use in pediatric and adult surgical procedures.THIS STUDY IS ENROLLING BY INVITATION ONLY - …
Patterns of cerebral oxygenation after ventricular reservoir placement and CSF removal: a pilot study
B
Beatrice Stefanescu
What is the purpose of this study?About 25% of babies born prematurely (before 32 weeks gestation) develop brain bleeds (intraventricular hemorrhage or IVH), which could progress to the serious complication of post-hemorrhagic hydrocephalus (PHH). Infants with PHH may require neurosurgical intervention to relieve the increased pressure that builds up within …
Safety and Efficacy of Endovascular Treatment ofIntracranial Aneurysms with Surpass Elite with GUARDian Flow Diverter(GUARD)
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Bradley N. Bohnstedt, MD
The objective of the Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms with Surpass Elite with GUARDian Flow Diverter (GUARD) trial is to evaluate the safety and efficacy of the Surpass EliteTM with Guardian Flow Diverter System (FDS) in the treatment of unruptured, wide-neck saccular or fusiform, intracranial aneurysms …
Measuring Allostatic Load in a Pregnant Cohort
J
Jasmine D Johsnon
What is the purpose of this study?Our central hypothesis is that structural and personally-mediated racism and its association with adverse pregnancy outcomes can be measured. The overall objectives of this study are to measure the burden of racism in an obstetric population and its impact on preterm birth and hypertensive …
PREVENT ALL ALS
C
Cynthia Bodkin, MD
What is the purpose of this study?PREVENT ALL ALS is a prospective, observational cohort study enrolling individuals at risk for carrying inherited genetic variants known to be causative for ALS. This is a longitudinal observational study involving collection of clinical data, outcomes andbiofluid samples. There is also an optional sub-study …
Empagliflozin and Physical Function in CKD (EMPA-FUNCTION) Feasibility Study
K
Kenneth Lim
What is the purpose of this study?The purpose of the study is to assess the therapeutic benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in improving physical function in End Stage Renal disease (ESRD) patients. The study is using the drug Empagliflozin, a FDA approved drug for patients with advanced CKD. …
Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors (ADEPT-ICU)
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Babar Khan, MD
What is the purpose of this study?Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer’s disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT …
MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)
N
Noel Dasgupta
What is the purpose of this study?To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM.
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