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Found 594 results for iu-health-enterprise-system
A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection
S
Scott Goebel, MD
What is the purpose of this study?Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with theyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in inhildren, adolescents and young adults with refractory ADV infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) ord organ …
A PHASE 2, TWO-STAGE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE-ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF RLS-0071 IN NEWBORNS WITH MODERATE OR SEVERE HYPOXIC-ISCHEMIC ENCEPHALOPATHY UNDERGOING THERAPEUTIC HYPOTHERMIA WITH LONG-TERM FOLLOW-UP
B
Beatrice Stefanescu
What is the purpose of this study?Hypoxic-ischemic encephalopathy (HIE) affects approximately 4,000 to 12,000 persons annually in the United States. Mortality from HIE has been reported up to 60%, with at least 25% of survivors left with significant neurocognitive disability. Despite this vital unmet medical need, no pharmacological adjunct or …
Crohn's Disease: Pharmacokinetics, Efficacy, and Safety of Risankizumab in Pediatric Subjects with Moderately to Severely Active Crohn's Disease
T
Tina Zhang
The objective of this study is to assess the pharmacokinetics (PK), efficacy, and safety of risankizumab in pediatric subjects with moderately to severely active CD aged 2 to biologic therapies. THIS STUDY IS ENROLLING BY INVITATION ONLY
IS PATIENT KNOWLEDGE AND EXPECTATIONS FOR OUTPATIENT SHOULDER ARTHROPLASTY CONCORDANT WITH THEIR SURGICAL EXPERIENCE?
M
Mark Dillon
What is this study about?The purpose of the proposed study is to evaluate whether patient knowledge and expectations for outpatient primary total shoulder arthroplasty (replacement, TSA), defined as discharge to home from the post-acute care unit by midnight on the day of surgery, are concordant with their surgical experiences. THIS STUDY …
Improving sleep in acute respiratory failure survivors
B
Babar Khan, MD
The purpose of this study is to evaluate the impact of a sleep deprivation and disruption on quality of life of acute respiratory failure ICU survivors using sleep actigraphy. Sleep actigraphy is a method of measuring sleep parameters and average motor activity over a period of days to weeks using …
Master Screening and Reassessment Protocol (MSRP) for TierAdvancement in the NCI myeloMATCH Clinical Trials
R
Rita Assi
What is the purpose of this study?This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific laboratory tests to help improve participants' ability to register to clinical trials throughout the course of their myeloid cancer (acute myeloid leukemia or myelodysplastic syndrome) treatment. This …
A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis
N
Noel Dasgupta
What is the purpose of this study?MaesTTRo is an international, longitudinal, non-interventional study of adult patients with transthyretin (ATTR) amyloidosis. The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and …
A Randomized, Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL Pre-filled Syringe With 1 mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
D
Domenick Zero, DDS, MS
What is the purpose of this study?The purpose of this study is to demonstrate the comparability of ianalumab exposure following the sub-cutaneous (s.c.) administration of one injection of 300 mg/2 mL auto-injector (AI) versus two injections of 150 mg/1 mL pre-filled syringe (PFS), and to evaluate the safety and tolerability …
Voice Measures & Respiratory Kinematics in Children & Adults with & without Voice & Resonance Disorders
R
Robert Fujiki
This study will examine laryngeal physiology and respiratory kinematics in children and adults with and without voice disorders and cleft palate.THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants for the patient group will be patients of the Voice and Swallow Clinics, or craniofacial anomalies clinic at IUH. Speech-Language …
Testing the Addition of the Anti-Cancer Drug Venetoclax And/Or the Anti-Cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed Kmt2A-Rearranged or Kmt2A-Non-Rearranged Leukemia
A
Amanda J. Saraf, DO
This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangement (KMT2A-rearranged [R]) or without a KMT2A gene rearrangement (KMT2A-germline [G]). Venetoclax is in a class of medications called B-cell lymphoma-2 (Bcl-2) …
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