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Found 594 results for iu-health-enterprise-system
A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
H
Heba Ismail
Obesity prevalence in persons with T1D has increased, which further complicates managementd risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth withbesity as well as potential mechanisms to modify disease.
A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
N
Noel Dasgupta
The purpose of this study is to evaluate the safety and tolerability of extended dosing withwith hereditary transthyretin-mediated amyloid polyneuropathy (hATTR-PN).
Prevalence and Predictors of Hepatic Steatosis in Persons Living With HIV
N
Naga Chalasani, MD
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated withumulation that ranges from benign, non-progressive liver fat accumulation to severever injury, cirrhosis, and liver failure. NAFLD is the most common liver disease in USdults and the second leading cause for liver transplantation in the US. The natural …
Risk stratified treatment for patients with newly diagnosed juvenile myelomonocytic leukemia: A Phase I/II non-randomized study of trametinib and azacitidine with or without chemotherapy
S
Sandeep Batra, MD
This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with …
A Phase 2A, 2-Part, Open-Label, Non-Randomized, Multicenter, Single and Multiple DoseTrial to Evaluate Pharmacokinetics, Safety and Tolerability of Aztreonam and Avibactam ±Metronidazole in Neonates and Infants From Birth to Less Than 9 Months of Age WithSuspected or Confirmed Infections Due to Gram-Negative Pathogens Requiring IntravenousAntibiotic Treatment
A
Anna Elizabeth Thomas
The purpose of this study is to learn about the safety and effects of ATM-AVI for the possible treatment of infections caused by a type of bacteria called gram-negative bacteria.The study medicine is a combination of an antibiotic, aztreonam (ATM), and another medicine, avibactam (AVI), which is used to help …
Sinonasal Therapies and Histologic Correlations for Patients with Cystic Fibrosis in the Era of Highly Effective Modulator therapy
E
Elisa Illing
Establish a protocol for de-escalation of sinonasal therapies for patients on cystic fibrosis transmembrane regulator (CFTR) modulator therapies in a multidisciplinary fashion that includes a Rhinology perspective. Test the hypothesis that patients with cystic fibrosis on CFTR modulator therapy with refractory sinus disease exhibit continued tissue neutrophilic inflammation. THIS STUDY IS …
NF119: A Phase 2, Open-Label, Single Arm, Non-Controlled, Single-Stage Study to Evaluate the Safety and Effects of HLX-1502 in Patients with Plexiform Neurofibroma and Neurofibromatosis Type 1
S
Steven Rhodes
What is the purpose of this study?The trial will be an open label, single arm, phase 2 study in 20 participants. The study will assess the tolerability and efficacy of HLX-1502 in participants with NF1 16 years of age or older with progressive and/or symptomatic PN. THIS STUDY IS ENROLLING BY …
An Interventional Efficacy and Safety Phase 3 Double-blind 2-arm Study to Investigate IV Followed by Oral Fosmanogepix Compared With IV Caspofungin Followed by Oral Fluconazole in Adult Participants With Candidemia and/or Invasive Candidiasis
N
Nicolas Barros, MD
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemia and/or invasive candidiasis, a life-threatening fungal infection caused by several species of yeast called Candida.The study is seeking patients who have a diagnosis of …
Multicenter Randomized Controlled Trial Comparing Early Internal Fixation Versus NonOperative Care with Early Rehabilitation for LC1 Fragility Fractures of the Pelvis: a Pilot Study
Y
Yohan Jang
The overall goal of this research is to determine if early surgical treatment is more effective than nonoperative care and early rehabilitation at lowering the risk of complications in patients with pelvis fractures. Adult patients ages 60 years or older with a low-energy lateral compression type 1 (LC1) pelvis fracture …
PSMA-PET to Guide Prostatectomy: A Sub-study
C
Clinton Bahler, MD
This sub-study consists of a single treatment group of men that require a PET scan to guide their radical prostatectomy, every subject will receive an MRI and the PSMA (prostate specific membrane antigen) PET scan prior to their surgery to determine if the PSMA PET scan is helpful in detecting …
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