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Found 594 results for iu-health-enterprise-system
A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Comparative Analysis of Extracellular Vesicles in Polycystic Ovary Syndrome (PCOS), Congenital Adrenal Hyperplasia (CAH), and Premature Adrenarche (PA)
E
Erica Eugster, MD
M
Manahil Mustafa
What is the purpose of this study?Extracellular vesicles (EVs) are double-membrane particles that transport proteins, microRNAs (miRNAs), and lipids, playing a crucial role in cell-to-cell communication and reflecting the cellular environment. Recent research has highlighted their potential as biomarkers and therapeutic agents in various adult conditions, yet their role in …
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of Resmetirom for the Treatment of Metabolic Dysfunction- Associated Steatotic Liver Disease (Masld) in People Living With Human Immunodeficiency Virus (Hiv)
S
Samer Gawrieh, MD
The purpose of this research study is to test the safety and effectiveness of the study drug, resmetirom, in participants with MASLD and HIV. This is a research study to test a drug that is already on the market with a population that was not included in the original clinical …
Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (Vr-Cog)
S
Sikandar Khan, MD
Acute respiratory failure (ARF) accounts for 2 million admissions to adult intensive care units (ICUs) in the United States annually, and up to 80% of older adults with ARF suffer delirium, a form of ICU-related acute brain dysfunction. Delirium doubles the risk for new cognitive impairment or dementia within 12 …
A study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease using a Reduced-Intensity preparatory regime with Campath-1H Fludarabine and Melphalan
J
Jodi Skiles
The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation. The overall purpose of …
A multicenter safety study of unlicensed investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
J
Jodi Skiles
The purpose of this study is to evaluate the safety of administration of the investigational cord blood units by carefully documenting all infusion-related problems. THIS STUDY IS ENROLLING BY INVITATION ONLY - The study will enroll an unlimited number of transplant recipients at participating US transplant centers (up to 10 at …
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
L
Larry Markham
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by identifying important genetic modifiers for aortic and aortic valve disease severity. THIS STUDY IS ENROLLING …
The CHEC-SC Cohort Study: CHaractErizing CFTR Modulated Changes in Sweat Chloride and their Association with Clinical Outcomes (the CHEC-SC study)
D
Don Sanders, MD
This is a multicenter, cross-sectional, cohort study which will collect contemporary sweat chloride (SC) values from approximately 5000 Cystic Fibrosis (CF) patients prescribed and currently receiving commercially approved Cystic Fibrosis transmembrane conductance regulator (CFTR) modulator therapies. THIS STUDY IS ENROLLING BY INVITATION ONLY
Vitreoretinal structure and proliferative vitreoretinopathy cascade
A
Amir Hajrasouliha
The purpose of this study is to gain a better understanding of the structure of the vitreous (the clear gel that fills the space between the lens and the retina) and the reason behind the failure of most retinal detachment surgeries. There is a 10% failure rate for primary retinal …
Translational Breast Cancer Research Consortium Biospecimen & Outcomes Repository
K
Kathy Miller, MD
The purpose of this study is to develop a repository of clinical data and outcomes, with and without corresponding specimens from individuals who have participated in TBCRC studies.
Pregnancy at a Time that is Happy and Healthy for You (PATH4YOU)
J
Jeffrey Peipert, MD
In an effort reduce maternal and infant mortality and health disparities overall, PATH4YOU (Pregnancy At a Time that’s Healthy and Happy for You) will be implemented starting in Marion County, and will ultimately be a statewide comprehensive contraceptive access program that ensures that patient-centered counseling and same-day access to no …
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