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Found 594 results for iu-health-enterprise-system

A listing of iu-health-enterprise-system medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems

Z
Zachary Adams
12 years - 17 years
All genders
Interventional
The purpose of this study is to find out if a short-term treatment (called a brief intervention) can help youth who screen positive for alcohol and/or substance use reduce their use of substances.  AIM 1:Compare the effectiveness of a youth-focused brief-intervention (TI) when delivered without caregiver involvement (TI-A) vs. with an …
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Online study

Indiana Neuroimaging and Biomarker Study of Anti-Amyloid Treatments

D
Donna Wilcock
All genders
Observational
What is the purpose of this study?The goal of this research is to create a repository of brain imaging and biological samples to study individuals undergoing clinical treatment with anti-amyloid therapies and compare them with samples and images from healthy individuals and cognitively impaired individuals not receiving these treatments. We …

Total Shoulder Arthroplasty Multi-Center Registry study

M
Mark Dillon
18 years - 100 years
All genders
Observational
What is the purpose of this study?This study is an ongoing, non-randomized, multi-center, prospective registry utilizing primary or revision shoulder arthroplasty implants.  Subjects will be treated according to standard of care at each center. The objective of the study is a multi-center prospective registry to collect clinical outcomes of anatomic …

The Utility of Silk Bioprotein as a Wound Dressing in Female-to-Male Double-Incision Mastectomy

I
Ivan Hadad
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This study will investigate the utility of Silk bioprotein, an FDA-approved and readily available post-surgical dressing, as a wound dressing for patients undergoing double-incision mastectomy for female-to-male gender affirmation surgery.THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients will be those who are already …

Comparing Optimal Step-down Therapy for Children with Invasive MRSA Trimethoprim-Sulfamethoxazole vs. Clindamycin for the Treatment of Children with Invasive MRSA Infections

J
James Wood, MD
60 days - 80 years
All genders
Interventional
What is the purpose of this study?This is a comparative effectiveness study of two antibiotics typically prescribed in the clinical setting of pediatric patients with osteoarticular infections (OAI, including acute osteomyelitis and septic arthritis) and head and neck infections (HNIs) caused by methicillin resistant Staphylococcus aureus (MRSA).. The goal of …

The Heart Outcomes in Pregnancy Expectations for Mom and Baby Study

C
Caroline Rouse, MD
18 years - 100 years
Female
Observational
This is a prospective, observational study which is evaluating the obstetrical, neonatal, and cardiovascular outcomes of 1000 pregnant people with known heart disease to define how best to structure cardio-obstetrics care to optimize outcomes.THIS STUDY IS ENROLLING BY INVITATION ONLY - This study is enrolling participants from specified community and …

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Compensated Cirrohosis Due to Nash/Mash

R
Raj Vuppalanchi, MD
18 years - 80 years
All genders
Phase 3
Interventional
This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.THIS STUDY IS ENROLLING BY INVITATION ONLY

Kysa-6: A Phase 2/3, Open-Label, Randomized, Controlled, Multicenter Study of Kyv-101, an Autologous Fully Human Anti-Cd19 Chimeric Antigen Receptor T-Cell (Cd19 Car T) Therapy, Versus Ongoing Standard-Of-Care Immunosuppressive Therapy in Patients With Generalized Myasthenia Gravis

A
Alex Barboi
18 years - 75 years
All genders
Phase 2/3
Interventional
Myasthenia gravis (MG) is a chronic autoimmune disease that affects the neuromuscular junction and is characterized by muscle weakness. B cells play a role in MG, and the disease is characterized by the presence of autoantibodies such as anti-AChR and anti-MuSK antibodies. CD-19 target chimeric antigen receptor (CAR) T cells …

Evaluation Of Endothelial Cell And Other Lung Cell Populations In Lung Explants From Pvd Patients

D
David Roe, MD
18 years - 60 years
Accepts healthy volunteer
All genders
For patients with pulmonary vascular disease (PVD) in its end stage, lung transplantation becomes the only viable treatment option. Our study proposes to utilize lung explants from transplant recipients, organs deemed unsuitable/rejected for transplantation, and donors to evaluate cellular populations and molecular mechanisms in both diseased and healthy conditions, offering …

Low-Dose Radiation Therapy for Osteoarthritis: A Prospective Phase II Trial to Assess Pain Response

A
Arpan Prabhu
All genders
Phase 2
Observational
Low dose radiation in the treatment of benign diseases, including musculoskeletal disorders such as arthritis, is a standard clinical practice commonly utilized in some practices in the United States and even more commonly utilized in countries in Europe. This study will evaluate patients' pain and quality of life responses to …
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