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Found 149 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

A
Anita Turk, MD
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). BRCA1 and BRCA2 are …
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Neoadjuvant pembrolizumab in patients with muscle-invasive bladder cancer with selective bladder sparing

J
Jennifer King
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?Subjects with cT2-T3N0M0 urothelial cancer of the bladder will be enrolled. After completingwo cycles of pembrolizumab, subjects will undergo a restaging MRI of the abdomen and pelvis with a standard acquisition protocol (as outlined in the protocol) as well as CT chest. A CThe …
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Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer (PERSEVERE)

B
Bryan Schneider, MD
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is a 3-arm study stratified by plasma ctDNA. Patients with residual TNBC disease afterve therapy will be assigned to 1 of 3 Arms based on plasma ctDNA positivity and genomic marker(s).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, …
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PSMA-PET to Guide Prostatectomy

C
Clinton Bahler, MD
40 years - 80 years
Male
Phase 2/3
Interventional
What is the purpose of this study?This study will randomize subjects to either standard of care MRI prior to radical prostatectomy or standard of care MRI and the PSMA (prostate specific membrane antigen) PET scan prior to radical prostatectomy to see if this scan will be helpful in detecting prostate …
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Dose Escalation Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) in Patients With Selected Advanced or Metastatic Solid Tumors

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1
Interventional
What is the purpose of this study?This is a first-in-human, Phase I, open-label, multicenter study designed to evaluate they, tolerability and preliminary efficacy of WTX-124, a conditionally-activated IL-2drug, when administered as monotherapy and in combination with pembrolizumab, for thewith advanced solid tumors. THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

N
Nabil Adra, MD
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?This is an open label randomized phase II trial of maintenance oral etoposide vs. observationwith relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood(PBSCT).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened …
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Exercise in Metastatic Breast Cancer: EMBody

T
Tarah Ballinger, MD
18 years or above
All genders
Phase 2
Interventional
What is the purpose of this study?The purpose of this study is to study exercise in a novel population with indolent MBC (nogression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensitybic and resistance training exercise for …
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Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer (STAR)

S
Sharon E. Robertson
18 years or above
Female
Phase 2
Interventional
What is the purpose of this study?The purpose of this research study is to test the safety of Niraparib and dostarlimab as abination treatment and see what effects (good and bad) this combination treatment has onwith recurrent or progressive cervix cancer.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with …
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Using Circulating Tumor DNA to Personalize Duration of Consolidation Durvalumab

N
Nasser Hanna, MD
18 years - 100 years
All genders
Phase 2
Interventional
What is the purpose of this study?This research aims to incorporate ctDNA analysis into clinical practice to individualize therapy in patients with stage III NSCLC by moving to a treatment-by-marker based approach (as opposed to treatment based on clinical or radiographic evidence of disease).THIS STUDY IS ENROLLING BY INVITATION ONLY …
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GammaTile and Stupp in Newly Diagnosed GBM (GESTALT)

M
Mitesh Shah, MD
18 years - 100 years
All genders
Phase 4
Interventional
What is the purpose of this study?This study seeks to explore if GT, given its unique radiobiological and physical characteristics, may permit safe dose escalation and intensification and thereby provide a benefit to newly diagnosed GBM patients in terms of OS and LC when incorporated into the framework of the …
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