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Found 27 Leukemia trials

A listing of Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

S
Sandeep Batra, MD
1-25 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with …
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Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation

S
Sandeep Batra, MD
24-18 years
All genders
Phase 2
Interventional
What is the purpose of this study?This trial studies the side effects of enasidenib and to see how well it works in treatingwith acute myeloid leukemia that has come back after treatment (relapsed) or has been difficult to treat with chemotherapy (refractory). Patients must also have a specific genetic change, …
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Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

T
Toshihiro Onishi, MD
6-21 years
All genders
Phase 3
Interventional
What is the purpose of this study?This phase III trial compares hematopoietic (stem) cell transplantation (HCT) usinghed related donors (haploidentical [haplo]) versus matched unrelated donors (MUD) ing children, adolescents, and young adults with acute leukemia or myelodysplasticyndrome (MDS). HCT is considered standard of care treatment for patients with high-riskute leukemia …
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A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

A
April Rahrig, MD
3-39 years
All genders
Phase 1/2
Interventional
What is the purpose of this study?The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic blood or marrow transplant (BMT) and determine whether the addition of Vorinostat to the standard graft versus host disease …
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Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

S
Sandeep Batra, MD
1-21 years
All genders
Phase 1
Interventional
What is the purpose of this study?Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric …
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A Phase 2 Study of SNDX-5613 in Combination With Chemotherapy for Patients With Relapsed or Refractory KMT2A-Rearranged Infant Leukemia

A
Amanda J. Saraf, DO
1-6 years
All genders
Phase 2
What is the purpose of this study? This phase II trial tests the safety and best dose of revumenib when given together with chemotherapy, and how well the treatment regimen works for infants and young children with leukemia that has come back (relapsed) or does not respond to treatment (refractory) and …
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Children and their Caregivers Needed for Play Activities During Cancer Treatment Study

S
Sheri Robb
3-8 years
All genders
Researchers at Indiana University School of Nursing/Riley Children's Hospital are looking for children and their parents/caregivers to take part in a study to find out how play activities, like stories and music, can be used to help lower young child and caregiver stress and improve quality of life during cancer …
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T-Cell Leukemia/Lymphoma Biorepository

U
Utpal Dave, MD
100 years and younger
All genders
What is the purpose of this study?The purpose of this study is to collect and store specimens for future research related to T-Cell lymphoma and leukemia diagnosis and treatment.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by …
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A Phase 1 study of GRN163L (Imetelstat, IND# 170891, NSC# 754228) in combination with fludarabine and cytarabine for patients with acute myeloid leukemia that is in second or greater relapse or that is refractory to relapse therapy; myelodysplastic syndrome or juvenile myelomonocytic leukemia in first or greater relapse or is refractory to relapse therapy

B
Brian Weiss
1-18 years
All genders
Phase 1
What is the purpose of this study?This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that has not responded to previous treatment (refractory) …
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A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy

R
Rachael Schulte
15-40 years
All genders
What is this study about?To determine in a randomized manner whether the addition of levocarnitine prophylaxis to asparaginase-containing regimens will decrease the incidence of conjugated hyperbilirubinemia (>3 mg/dL) during ALL induction therapy for adolescents and young adults (AYAs, age 15-39 years) To examine the impact of levocarnitine prophylaxis on differences …
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