Health Research
and Clinical Studies

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

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Browse by Featured categories

Aging
Children, Families & Pregnancy
Dental
Online
Alcohol, Tobacco, or Other Substance Use
Alzheimer’s Disease & Dementia
Asthma,Lungs & Allergies
Bones, Muscles and Joints
Brain, Spine & Nervous System
Covid-19 & Infectious Disease
Diabetes, Heart and Blood Vessels
Digestive System (GI), Bowel & Liver
Health Mental, Behavioral Health & Developmental Conditions
Healthy Volunteer
Cancer
Diet, Nutrition, Exercise, & Sleep

Browse by Featured categories

Aging
Alcohol, Tobacco and Substance Use
Brain, Spine and Nerves
Cancer
Diabetes
Diet, Exercise and Nutrition
Healthy Volunteers
Mental and Behavioral Health
Alzheimer’s Disease and Dementia
Autoimmune Disease
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Bones, Muscles and Joints
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Online Studies
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Recently added/updated trials

IS PATIENT KNOWLEDGE AND EXPECTATIONS FOR OUTPATIENT SHOULDER ARTHROPLASTY CONCORDANT WITH THEIR SURGICAL EXPERIENCE?

M
Mark Dillon
18 years - 100 years
All genders
Observational
What is this study about?The purpose of the proposed study is to evaluate whether patient knowledge and expectations for outpatient primary total shoulder arthroplasty (replacement, TSA), defined as discharge to home from the post-acute care unit by midnight on the day of surgery, are concordant with their surgical experiences.  THIS STUDY IS ENROLLING BY INVITATION ONLY -  Study-eligible patients scheduled for elective primary total shoulder replacement (TSA) with the study surgeon Dr. Matt Dillon will be informed about the study at their preoperative initial diagnostic visit.

A Randomized Controlled Trial Comparing Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy for the Management of Severe Open Tibia Fracture Wounds

Y
Yohan Jang
18 years - 100 years
All genders
Interventional
What is this study about?Open tibia fracture complications are debilitating for patients. NPWT is the current standard of care for temporary wound management of severe open fractures requiring multiple debridements. Emerging comparative studies suggest that the antibiotic bead pouch may significantly reduce the risk of open fracture infection and its related complications compared to NPWT. The primary objective is to determine if the antibiotic bead pouch, compared to NPWT application, is more effective at reducing open tibia fracture complications. THIS STUDY IS ENROLLING BY INVITATION ONLY  THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients with an open tibia fracture (OTA 41, 42, 43) will be screened for eligibility in the emergency room by research personnel, prior to going to the operating room for the first irrigation and debridement of the open fracture and wound. The final determination of eligibility will take place in the operating room when the surgeon determines if the patient will require subsequent irrigation and debridement procedures to manage the open injury. Patients with bilateral tibia fractures will be eligible for inclusion; however, only the most severe eligible fracture will be included, as determined by the attending surgeon.  

Multi-Institutional Cohort Study of a Non-invasive Technique for Bedside Reduction of Giant Omphaloceles

M
Matthew Landman, MD
1 weeks or below
All genders
WHY IS THIS STUDY BEING DONE?The main reason for this research study is to understand what happens with patients who are treated for giant omphaloceles (GO) using a non-invasive staged closure technique that uses a hydrocolloid (Duoderm CGF) silo. Omphaloceles are a rare (birth) defect where infants are born with incomplete closure of the muscle/tough layer of the abdominal wall. THIS STUDY IS ENROLLING BY INVITATION ONLY -  Infants who are born with a giant omphalocele (GO) that cannot be immediately closed and are treated by pediatric surgeons at Riley Hospital for Children following birth will be invited to participate in this study.

Comprehensive Wound Center WoundQ Questionnaire

M
Mithun Sinha
18 years - 100 years
All genders
Observational
What is the purpose of this study?The purpose of this study is to utilize the WoundQ survey, widely used among wound care clinics to understand the impact that chronic wounds have on your life. There are a total of 9 sections throughout the survey that gauge the following: the concern the participant experiences related to their chronic wound, the specific characteristics such as odor, drainage, and other descriptions that are of concern, the emotional and social outcomes that occur as a result of having a chronic wound, as well as their experience with care they’ve received and overall treatment. Overall, the goal of this study is to better understand the impact that chronic wounds have on our patient population. THIS STUDY IS ENROLLING BY INVITATION ONLY - Prospective participant will be identified using Wound Expert and Cerner EMR system. Assuming they meet the eligibility criteria, patient will be approached during their routine standard of care appointment where study personnel will review all study-related elements. If patient proceeds with study, WoundQ survey will be administered.

Determining the presence and significance of atherosclerotic plaque-associated biofilms in peripheral arterial disease

M
Mithun Sinha
18 years - 100 years
All genders
Observational
What is the purpose of this study?This study will examine the relationship between bacteria and biofilms in tibial arteries and lower limb tissue and patient characteristics in a population with critical limb threatening ischemia (CLTI), who have undergone lower extremity amputation. The study will analyze tissue samples from amputation specimens to identify the presence of biofilms in atherosclerotic plaques or arteries in patients with CLTI to identify the presence of bacteria or biofilms in lower limb tissue and to identify the causative bacteria from the samples collective.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients will be identified by one of the physicians on the study in the inpatient or outpatient clinic as needing a major limb amputation. The physician will then refer that subject to the study team, and the study team will contact the potential subject either in clinic or during the pre-operative setting. The IU clinical locations will be sites for subject recruitment, enrollment and conducting study activities.

Comparing treatment, costs, and patient outcomes of close-range vs long-range GSWs to the upper extremity.

E
Erin Weber
18 years - 100 years
All genders
Observational
What is this study about?The purpose of this study is to measure outcomes related to close-range and long-range gunshot wounds to the hand, wrist, and arm.   THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients will be identified and recruited by Dr. Weber and other hand surgeons providing care for the gun shot injury to the upper extremity in the Departments of Plastic Surgery and Orthopedic Surgery through IU Health and Eskenazi.

Craniosynostosis Patient-Reported Outcomes Using the FACE-Q Scales: A Prospective Observational Study

K
Katelyn Makar
21 years or below
All genders
Observational
What is the purpose of this study?Craniosynostosis can affect normal brain development by causing local or regional increases in intracranial pressure. The goals of surgery in the treatment of craniosynostosis are to improve the appearance and morphology of the skull and to prevent functional disturbances such as intracranial hypertension and ophthalmologic complications. The proposed study aims to use the FACE-Q Craniofacial Module to assess long-term patient-reported outcomes regarding satisfactions with their appearance and quality of life after surgery to repair craniosynostosis. The FACE-Q Craniofacial modules provides a validated method of collecting satisfaction data for patients, using appearance and quality-of-life variables which are relevant and meaningful for patients and parents. THIS STUDY IS ENROLLING BY INVITATION ONLY - Potentially eligible patients and their parents/guardians will be approached in clinic in IU Health facilities by study staff about study participation.