This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR). THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic.  Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632

To evaluate the long-term safety and tolerability of AOC 1001 in DM1 patients.THIS STUDY IS ENROLLING BY INVITATION ONLY -   The study will invite participants with DM1 who completed a prior study with AOC 1001 to participate.

Low dose radiation in the treatment of benign diseases, including musculoskeletal disorders such as arthritis, is a standard clinical practice commonly utilized in some practices in the United States and even more commonly utilized in countries in Europe. This study will evaluate patients' pain and quality of life responses to this standard treatment through the use of surveys before and after their treatment for arthritis in our facilities.THIS STUDY IS ENROLLING BY INVITATION ONLY - Surveys and chart review will be performed within hospital clinics at IU Health for patients receiving LDRT for osteoarthritis. Some patients may be referred by other physicians or hear from word of mouth about this study. Patients will be seen in clinic during routine consultation appointments, and the study will be explained to them then. We will also email potential referring providers to let them know about the study using the provided email template.After consenting to the study, they will fill out pain score and quality of life surveys before and after undergoing the standard treatment with LDRT.

The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function. THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants will be identified by clinical staff, who will inquire if they are interested in research. 

The purpose of this study is to investigate the effectiveness of two different frequencies of physical therapy sessions on the recovery of mobility, function, and other measures of health in individuals more than 6 months following stroke. THIS STUDY IS ENROLLING BY INVITATION ONLY - Physical therapists and physicians treating patients post-stroke both at the Rehabilitation Hospital of Indiana and surrounding rehabilitation facilities will be made aware of this study and may refer patients to our study by providing the flyer or laboratory contact information. Other sources of recruitment include flyers posted at the Rehabilitation Hospital of Indiana and provided to physical therapists and physicians in the surrounding area which may be distributed to participants. Members of the study team may also review medical records of Rehabilitation Hospital of Indiana patients to identify and contact potential subjects.

What is the purpose of this study?The goal of this phase I/II multicenter clinical trial is to improve walking function, dynamic stability, and community mobility in people with multiple sclerosis (MS) using a novel combination of high-intensity training and an environment that challenges dynamic balance. THIS STUDY IS ENROLLING BY INVITATION ONLY - People with MS will be referred primarily by the attending rehabilitation physicians or therapy staff of the participating clinics. At the Indianapolis site, potential participants with multiple sclerosis will be referred from the Rehabilitation Hospital of Indiana clinical inpatient and outpatient rehabilitation centers as well as Indiana University (IU) Neurology (Dr. Mattson).  Other referral sites include admissions from the St. Vincent Health System, Eskenazi (Wishard) Health Center and St. Francis/Franciscan Rehabilitation. Clinicians (Drs. Obeidat or Mattson) will prereview each individual's eligibility based on the inclusion/exclusion criteria, which will require a review of the individual's medical record. If the individual meets the inclusion/exclusion criteria contained in the medical records, the clinician or an aliated clinical research coordinator will approach the individual about possible participation in the study.