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Help Shape the Future of Health
with the Indiana Biobank
By donating a small blood sample, you can help researchers discover better treatments and improve health across Indiana.
Who Can Join?
All IU Health Patients of Any Age
What Is Involved?
It's easy-we collect a blood sample during your regular doctor visit.
Why does it Matter?
By taking part, you're helping improve care for you, your loved ones, and people across Indiana.
Recently added/updated trials
Caregivers of Individuals Living with Alzheimer's or Related Dementia Needed to Test a Mobile App
R
Richard Holden
Why is this study being done?The I-CARE 2 study is looking for unpaid caregivers of community-dwelling individuals living with dementia to test a technological intervention. The purpose of the study is to test the effects of a smart phone application on alleviating caregiver burden and improving the behavioral and psychological health of people living with dementia. Who can take part?Unpaid primary caregivers of community-dwelling individuals living with Alzheimer's disease or related dementia (ADRD).
A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Iptacopan (LNP023) in Complement 3 Glomerulopathy.
M
Myda Khalid
The purpose of this study is to evaluate the efficacy and safety of iptacopan compared to placebo and standard of care in patients with native C3G. CLNP023B12301 is a Phase 3 pivotal trial for registration of iptacopan in C3G. The study aims to determine the reduction in UPCR and improvement in eGFR in participants treated with iptacopan compared to placebo, as well as the proportion of participants who achieve a composite renal endpoint consisting of eGFR and UPCR elements. These effects of iptacopan in conjunction with increases in serum C3 levels will provide support for an iptacopan profile that includes stabilization of eGFR, clinically meaningful reductions in proteinuria and inhibition of the complement AP. THIS STUDY IS ENROLLING BY INVITATION ONLY
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Study Evaluating the Safety and Efficacy of Lb-P8 in Patients with Primary Sclerosing Cholangitis (Psc)
R
Raj Vuppalanchi, MD
The study is designed to assess the safety and efficacy of LB-P8 in patients with primary sclerosing cholangitis.THIS STUDY IS ENROLLING BY INVITATION ONLY
Pelvic Health Electrically Evoked Recording (PEER) 2 Study
C
Charles Powell, MD
The purpose of this study is to collect recordings of signals resulting from stimulation of a sacral nerve (stimulation evoked signals) using prototype investigational systems. Signals will be collected using various stimulation paradigms at several time points after lead implant during the therapy evaluation period. Signals will also be collected as the subject completes activities of daily living to understand factors that contribute to signal features. Learnings from this study may be used to inform future engineering efforts to support development of sensing-based hardware and possible algorithm development.THIS STUDY IS ENROLLING BY INVITATION ONLY
Shortstop-Her2: Shortened Duration of Adjuvant Therapy in Patients with Early-Stage Her2+ Breast Cancer Who Achieve Pcr After Neoadjuvant Chemotherapy with Her2 Blockade
K
Kathy Miller, MD
This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumabInterested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
Struggling With Depression? Learn About A Study Exploring New Options For Adults Living With Treatment-Resistant Depression
S
Susan Conroy, MD PhD
Still searching for relief from depression? Have you tried multiple treatments for depression without success? You may have another option.When treatments haven’t worked, research may offer a new path. The Abbott TRANSCEND study is a research study for adults with depression who have not felt better after trying at least four different antidepressant medications. The purpose of the study is to learn how safe and effective a treatment called deep brain stimulation (DBS) may be for people with treatment-resistant depression. DBS uses a medical device made by Abbott to deliver gentle electrical signals to specific areas of the brain. This treatment is still being studied and is not yet approved for this use.You may qualify to join this study if you:Are between the ages of 22 and 70Have been diagnosed with depression and are currently experiencing a depressive episode for at least 12 monthsHave tried at least 4 different treatments without successAre willing and able to attend regular study visits at the IU Health Neuroscience Center in Indianapolis, IN over the course of 3 years Please visit this link to complete registration to be contacted for this study: https://redcap.link/TRANSCEND
Are You Pregnant? Join Our Study About Vaccination During Pregnancy
S
Soojung Jo
We are inviting pregnant women ages 18 and older who are currently living in Indiana to take part in our study.We want to learn how you use vaccine-related information sources when making decisions about vaccines like Tdap and the flu vaccine.You will be asked to complete a short online survey (10-15 minutes) about your attitudes, experiences, and sources of vaccine information. Together, we can better understand how online health information affects expectant mothers.
