The Oral Health Research Institute (OHRI) has a long history of using partial dentures and oral appliances containing tooth specimens to determine how effective dental products are at reducing cavities and preventing erosive tooth wear (wearing down of the tooth at the gumline). In this study we are asking patients to use a new appliance made from a 3D printer that will fit over their existing lower back teeth that can hold tooth specimen to test dental products for both cavities and erosive tooth wear at the same time. The purpose of this study is to test two new methods, one for cavities and one for erosive tooth wear, using tooth specimens placed in 3D-printed lower appliance that will be worn over the patient's existing lower back teeth . The testing to reduce the formation of cavities will be done in specimens placed on the right side (color-coded blue) of the appliance, while reducing the formation of erosive tooth wear will be done in specimens placed on the left side (red) with the specimens tested in the lab independently.THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects who previously participated in other Oral Health Research Institute studies (OHRI) or who have contacted OHRI expressing interest in potential studies will be contacted by a team member who will conduct a screening phone interview. If the potential subjects appear to qualify, they will be scheduled for the screening visit.

The purpose of this project is to collect and analyze relevant clinical data from children who have been identified as having a positive newborn screen for severe combined immunodeficiency (SCID) in order to understand the most common causes of SCID in Indiana, identify important immune parameters, determine the safest prophylactic measures, track the outcomes of treatment for SCID, and improve our overall care of this special population of children within our state.THIS STUDY IS ENROLLING BY INVITATION ONLY - We are the main referral center for newborns who screen positive for severe combined immunodeficiencies. We then take over to continue the diagnostic work-up and care of these patients. We will attempt to recruit families to become a part of this project and explain why gathering and studying this data is important. 

To better understand the efficacy of a person-centered approach to enhance health empowerment/self-efficacy and engagement among persons with chronic Traumatic Brain Injury (TBI).THIS STUDY IS ENROLLING BY INVITATION ONLY - Brain injury physician clinics across the US will refer potential participants. Brain injury physicians recruiting for this study are a part of the PI’s network of professional contacts. To refer a patient, the brain injury physician will facilitate recruitment by briefly discussing the study with their patient, which may include sharing recruitment materials. Only patients the physician believes to be eligible will receive recruitment materials. 

What is the purpose of this study?The primary objective of this study is to provide data for research to improve care and outcomes for individuals with traumatic brain injuries. The Traumatic Brain Injury Model System National Database is a multi-center, prospective, longitudinal study used for descriptive analyses of outcome, correlation of injury severity and for monitoring trends over time. Information being collected will include demographic, date of birth, height, weight, substance and tobacco use history, disability ratings, injury information, level of function, types of treatment received and quality of life. Subjects in the study authorize further contact regarding research studies or new services that may be of benefit to them. Subjects will be contacted periodically to gather follow-up recovery and outcome information. THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential subject will be identified upon admission to the rehabilitation facility through admissions reports. Eligible individuals will be randomly selected to participate in the research. Through a Pilot portion of the study any potential subject with disorders of consciousness will be identified and included in the study without randomization. Study staff will introduce the substudies to eligible participants over the phone at the end of the existing data collection measures or as a separate phone call. Study staff may also approach subjects in-person to introduce substudies for which they are eligible.

This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival and improvement in quality-of-life.THIS STUDY IS ENROLLING BY INVITATION ONLY

A multi-center, 26-week randomized controlled trial (RCT) to evaluate the safety and efficacy of the fully closed loop Omnipod M System in adults with type 2 diabetes using basal/bolus insulin therapy or basal-only insulin therapy, with the primary endpoint after 15 weeks and secondary analysis at 26 weeks; followed by an extension phase after completion of the 26-week trial where the Intervention group will continue to use Omnipod M and the Control group will crossover to use Omnipod M for 26 weeksTHIS STUDY IS ENROLLING BY INVITATION ONLY