The purpose of this study is to understand how to provide better care to and improve outcomes in mothers and infants who are exposed to opioids during pregnancy in Marion County, Indiana. Care Plus will examine the various factors that may contribute to improved NAS outcomes and impact on the family unit. THIS STUDY IS ENROLLING BY INVITATION ONLY - Participants will be recruited from Prenatal clinics within faculty practices and identified babies diagnosed with or at risk of Neonatal Abstinence Syndrome (NAS) at any Indianapolis hospital.

The purpose of this study is to thoroughly examine kidney stones, kidney tissue, urines, and medical history of patients to help determine causes and/or the most effective treatments, including preventative treatments, of kidney stones. THIS STUDY IS ENROLLING BY INVITATION ONLY 

The research goal is to understand the pathogenesis and molecular mechanisms of pulmonary disease and find new ways to detect, treat, and maybe prevent or cure lung diseases. Our study goals are to analyze lung tissue samples for molecular markers, gene expression profiles and other cellular features. Tissue samples and medical information will be collected so researchers can use them in future studies to understand the causes of diseases, and develop new treatments. THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects will be identified by the IU Health Lung Transplant team and that team will then notify the research coordinator about a potential subject. The research coordinator will approach the patient at a standard of care visit after the PI or sub investigator has explained this study.

Pulmonary hypertension (PH) is an uncommon disease characterized by increased blood pressure in the pulmonary artery, which can lead to right heart failure and death. PH may be related to conditions such as collagen vascular diseases like scleroderma, congenital heart defect, portal hypertension, HIV infection, or exposure to drugs/toxins such as anorexigens or methamphetamine. It can also be a complication of other heart or lung diseases, such as pulmonary fibrosis. The causes of PH are not well understood, and treatments are currently limited.  The goal of this study is to understand more about what causes PH and to identify prognostic biomarkers in the blood. It will include genetic studies to look for changes that make some people more likely to develop PH. Blood cells from patients' samples may be re-programmed into vascular cells, to enable studies on the cell types that are most involved in causing PH. These studies will help us to understand the differences between cells from people with or without PH, and in future to test new drugs that might correct these changes. THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients with pulmonary hypertension may present to the hospital with cardio-pulmonary failure and require sedation and mechanical ventilation. Critical illness may affect cognitive function. Subjects will be asked to give additional samples of blood, which will be taken as part of a routine blood draw, or from an existing catheter (small tube placed in blood vessel that is used to give fluids, drugs and to take blood samples).

The purpose of this study is to create a research registry of patients with NAFL (non alcoholic fatty liver) or NASH (non alcoholic steatohepatitis)in order to assess the safety and effectiveness of current and future therapies. The goal is to identify the factors associated with favorable versus suboptimal clinical response to improve health and reduce the development of liver cancer in this patient population. THIS STUDY IS ENROLLING BY INVITATION ONLY 

The purpose of this research study is to help determine the best treatment for preventing blood clots that are formed following trauma that could potentially lead to death. At the moment researchers do not know if using medications called low molecular weight heparin or aspirin is better in preventing life threatening blot clots in trauma patients. In this study, we are trying to answer this question. Usually either low molecular weight heparin is given by subcutaneous (under the skin) injections (liquid) medicine or aspirin (pill) medicine is given by mouth while in the hospital and after hospital discharge to prevent blood clots. There has not been a study to compare these two types of medicines for preventing blood clots in trauma patients and order to find out which medicine is best this study will compare these two forms of treatment.

The purpose of this study is to evaluate the safety, tolerability, and effectiveness of TAF against the hepatitis B virus in children and adolescents. The 25 mg dose of TAF is the dose that has been selected for studies in adults with chronic hepatitis B. In a type of testing called pharmacokinetics (PK), researchers will measure the amount of TAF in the child’s blood and determine how the body takes in, distributes, processes, and removes it. THIS STUDY IS ENROLLING BY INVITATION ONLY - Participants will be identified utilizing an IRB approved database of current patients who are actively being seen by our department's physicians, medical records or clinic schedules, or physician/provider referral. We will contact those who are established standard of care patients and have been added to the hepatitis IRB approved database.