This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.

What is the purpose of this study?The purpose of this research is to learn more about how the levels of different lipids affect kids with asthma and obesity. We're especially interested in how it affects kids with certain characteristics or types of asthma. In the long term, we hope this will help us understand if taking algae oil (high in certain types of lipids) might help some kids with asthma control their symptoms and reduce inflammation in their lungs.THIS STUDY IS ENROLLING BY INVITATION ONLY - Screening will occur in collaboration with the treating clinical providers, who will identify potentially eligible subjects from the Pulmonary and Allergy clinics, the Riley ED, and the inpatient Pulmonary team. A member of the research study team will then proceed to obtain parental informed consent; assent will also be obtained from all children >8 years old. Subjects might also be recruited using word of mouth and/or siblings of participants. We might also recruit subjects from IU North (same clinics and departments), but all study visits will take place at Riley.

What is the purpose of this study?The purpose of this study is to assess the long-term safety and effectiveness of odevixibat in participants with Alagille syndrome (ALGS).The participants of this study will have ALGS a rare genetic disorder that can affect multiple organ systems of the body including the liver, heart, skeleton, eyes and kidneys. Common symptoms, which often develop during the first three months of life, include blockage of the flow of bile from the liver (cholestasis), yellowing of the skin and mucous membranes (jaundice), poor weight gain and growth and severe itching (pruritis).The drug used for the study is odevixibat and was authorized for the treatment of cholestatic pruritus in infants with ALGS over 12 months of age by the United States Food and Drug Administration on 13 June 2023.THIS STUDY IS ENROLLING BY INVITATION ONLY -  Patients who participated in Study A4250-012 (ASSERT) and meet eligibility criteria for Study A4250-015 or potentially eligible infants identified by the study team may be invited to participate.

What is the purpose of this study?We propose using optic ultrasonography to measure optic nerve sheath diameter, as an indicator of intracranial pressure, within the glaucoma population at the Ophthalmology health clinics at Indiana University School of Medicine (Eugene and Marilyn Glick Eye Institute and Spring Mill clinic) to determine if low intracranial pressure plays a role in glaucoma patients, especially low tension glaucoma. If this study determines that using optic nerve sheath diameter in place of lumbar punctures is a reliable method to measure intracranial pressure, and that low intracranial pressure is involved in glaucoma, then this could indicate the possibility of a non-invasive, cost-effective method to evaluate intracranial pressure in glaucoma patients, aiding in earlier diagnosis.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Any patient seen in clinic at Eugene and Marilyn Glick Eye Institute that consents to optic ultrasonography and fits the inclusion criteria may be eligible and invited to participate.

What is the purpose of this study?The purpose of this study is to evaluate the gut microbiome and circulating microbial metabolites of children and adults with prediabetes and diabetes so we can compare the differences across different stages of diabetes but also across different forms of diabetes and different age groups.THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants will be identified by review of medical records and our diabetes registry database. We will then contact them by phone as well as in clinic or during their hospital stay to gauge their interest. Pediatric subjects will primarily be recruited from the Riley Pediatric Diabetes Team's patient population of type-1 diabetics during clinic visits or upon diagnosis and inpatient records. Recruitment will also occur at Diabetes clinics at Methodist Hospital. The onset of T1D in adults tends to be more gradual and some individuals may be first mis-identified as having Type 2 diabetes. However, we may have the opportunity to collect a blood or stool sample from an adult with T1D who is hospitalized or being seen in an outpatient Endocrinology clinic. Moreover, our diabetes team also has contact with adults with new onset T1D who self-refer for evaluation for other clinical research studies.

What is the purpose of this study?The purpose of this study is to develop a test for kidney disease that does not require a kidney biopsy or blood draw.  We will look at urine samples under a microscope and see if we find patterns in the kind of cells and how they appear in different kinds of kidney problems. We are using a special microscope called confocal microscopy that can take a close up of how cells appear. Our goal is to establish a urine biobank with samples from children with different types of kidney disease for biomarker studies. THIS STUDY IS ENROLLING BY INVITATION ONLY - Participants will be recruited from the inpatient, outpatient nephrology services and infusion center.  Potential research participants (children and adolescents) will be identified on the inpatient nephrology service or nephrology clinic and will be approached by study staff about participating.

What is the purpose of this study?This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic.  Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632</div>