What is the purpose of this study?The primary objective of this study is to provide data for research to improve care and outcomes for individuals with traumatic brain injuries. The Traumatic Brain Injury Model System National Database is a multi-center, prospective, longitudinal study used for descriptive analyses of outcome, correlation of injury severity and for monitoring trends over time. Information being collected will include demographic, date of birth, height, weight, substance and tobacco use history, disability ratings, injury information, level of function, types of treatment received and quality of life. Subjects in the study authorize further contact regarding research studies or new services that may be of benefit to them. Subjects will be contacted periodically to gather follow-up recovery and outcome information. THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential subject will be identified upon admission to the rehabilitation facility through admissions reports. Eligible individuals will be randomly selected to participate in the research. Through a Pilot portion of the study any potential subject with disorders of consciousness will be identified and included in the study without randomization. Study staff will introduce the substudies to eligible participants over the phone at the end of the existing data collection measures or as a separate phone call. Study staff may also approach subjects in-person to introduce substudies for which they are eligible.

This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival and improvement in quality-of-life.THIS STUDY IS ENROLLING BY INVITATION ONLY

A multi-center, 26-week randomized controlled trial (RCT) to evaluate the safety and efficacy of the fully closed loop Omnipod M System in adults with type 2 diabetes using basal/bolus insulin therapy or basal-only insulin therapy, with the primary endpoint after 15 weeks and secondary analysis at 26 weeks; followed by an extension phase after completion of the 26-week trial where the Intervention group will continue to use Omnipod M and the Control group will crossover to use Omnipod M for 26 weeksTHIS STUDY IS ENROLLING BY INVITATION ONLY

This Phase 2, randomized, double-blind, placebo-controlled, multi-center study will compare the safety, tolerability, and efficacy of inhaled LTI-03 to placebo in participants diagnosed with IPF within 5 years of Screening who may be receiving standard of care (SoC) antifibrotic therapy.LTI-03 is an experimental medication breathed into the lungs using an inhaler. It is being studied for the treatment of Idiopathic Pulmonary Fibrosis (IPF). IPF is a progressive, fatal lung disease caused by the death of lung cells involved in oxygen uptake and by progressive fibrosis (scarring) of the lungs. As the disease progresses, patients experience loss of lung function and increased breathing problems. LTI-03 is hypothesized to treat IPF by protecting and restoring the function of the oxygen uptake cells and by controlling lung fibrosis which may result in improving lung scarring.The purpose of this research is to evaluate LTI-03 including: its safety, whether it causes side effects, whether it improves lung scarring, and whether it improves IPF symptoms. LTI-03 will be compared to placebo in patients diagnosed with IPF within the last 5 years. Patients on a stable dose of nintedanib, pirfenidone, or nerandomilast (if available by prescription) may participate.THIS STUDY IS ENROLLING BY INVITATION ONLY

For preterm infants with bronchopulmonary dysplasia (BPD), the transition home from the neonatal intensive care unit (NICU) profoundly impacts both children and their parents.  The goal of this study is to establish patient-reported measures that refine neonatal illness risk-stratification and identify barriers to post-discharge specialty care, in order to implement hospital-to-home transition strategies that reduce post-prematurity respiratory disease for infants with BPD.THIS STUDY IS ENROLLING BY INVITATION ONLY - We will identify and screen eligible infants with BPD approaching NICU discharge, obtain informed consent from parents, and enroll subjects according to the approved protocol.

The purpose of this study is to understand the reasons why people develop strokes and how strokes contribute to the onset of dementia. We will do this by comparing people who have had an ischemic stroke with people who have silent brain infarcts, which are also called silent strokes. Silent brain infarcts are a condition in which the body does not exhibit any apparent signs or symptoms of a stroke but images of their brain show that they may have had a stroke. In this study we determine if particles in the blood called extracellular vesicles are different in people with silent brain infarcts compared to people without them.THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential subjects will be identified by research staff using medical records and approached by research staff.