What is the purpose of this study?This is a research study being done to see if adding a drug called epcoritamab to “salvage chemotherapy” GDP (gemcitabine + cisplatin, with dexamethasone) will better treat cancer than using chemotherapy alone.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632

This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103. THIS STUDY IS ENROLLING BY INVITATION ONLY

The Oral Health Research Institute (OHRI) has a long history of using partial dentures and oral appliances containing tooth specimens to determine how effective dental products are at reducing cavities and preventing erosive tooth wear (wearing down of the tooth at the gumline). In this study we are asking patients to use a new appliance made from a 3D printer that will fit over their existing lower back teeth that can hold tooth specimen to test dental products for both cavities and erosive tooth wear at the same time. The purpose of this study is to test two new methods, one for cavities and one for erosive tooth wear, using tooth specimens placed in 3D-printed lower appliance that will be worn over the patient's existing lower back teeth . The testing to reduce the formation of cavities will be done in specimens placed on the right side (color-coded blue) of the appliance, while reducing the formation of erosive tooth wear will be done in specimens placed on the left side (red) with the specimens tested in the lab independently.THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects who previously participated in other Oral Health Research Institute studies (OHRI) or who have contacted OHRI expressing interest in potential studies will be contacted by a team member who will conduct a screening phone interview. If the potential subjects appear to qualify, they will be scheduled for the screening visit.

The purpose of this project is to collect and analyze relevant clinical data from children who have been identified as having a positive newborn screen for severe combined immunodeficiency (SCID) in order to understand the most common causes of SCID in Indiana, identify important immune parameters, determine the safest prophylactic measures, track the outcomes of treatment for SCID, and improve our overall care of this special population of children within our state.THIS STUDY IS ENROLLING BY INVITATION ONLY - We are the main referral center for newborns who screen positive for severe combined immunodeficiencies. We then take over to continue the diagnostic work-up and care of these patients. We will attempt to recruit families to become a part of this project and explain why gathering and studying this data is important.