The primary objective of this study is to determine the preliminary feasibility and safety of high intensity stepping training for individuals with chronic (>6 months) cerebellar damage. Additionally, the secondary aim of this study is to assess the comparative efficacy of high intensity stepping training and conventional training on locomotor recovery, specifically walking endurance.To date, no studies have attempted to maximize both the amount and cardiovascular intensity of stepping practice in patients with cerebellar disorders.THIS STUDY IS ENROLLING BY INVITATION ONLY - Recruitment will occur primarily from the inpatient and outpatient rehabilitation centers of the Rehabilitation Hospital of Indiana, with secondary sources of recruitment from surrounding rehabilitation facilities via flyers/laboratory contact information provided to associated clinical staff and providers.

To evaluate the effectiveness of individually targeted, model-based dosing of serotherapy and chemotherapy conditioning on two-year post-HCT DFS in children with high-risk ALL, AML, MDS, or other hematological malignancies who are MRD-negative at the time of ex vivo TCRαβ+/CD19+-depleted haploidentical HCTTo evaluate the effectiveness of individually targeted, model-based dosing of serotherapy and chemotherapy conditioning on two-year post-HCT DFS in children with high-risk ALL, AML, MDS, or other hematological malignancies who are MRD-positive at the time of ex vivo TCRαβ+/CD19+-depleted haploidentical HCT.To characterize overall survival (OS), graft-versus-host disease (GVHD)-free relapse-relapse free survival (GRFS), and chronic graft-versus-host disease-free relapse-free survival (CGRFS) at 2-year post-HCT for children following model-based dosing of serotherapy and chemotherapy conditioning followed by ex vivo TCRαβCD3+/CD19+ depleted HCT.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic.  Interested in participating? For more information about this research study or other cancer-related clinical trials at Indiana University Simon Comprehensive Cancer Center (IUSCCC), please contact the IU Clinical Trials Office at:Email: iutrials@iu.eduPhone: (317) 278-5632

Are  you 40 years of age or older and living with heart failure? You may be able to join a study testing a new way to support people with heart failure from home.Heart failure can affect more than your heart.  Living with this condition can bring challenges that are not always easy to manage alone. Researchers at Indiana University are studying he ADAPT, a virtual care program for people with heart failure.  It is designed to help with common concerns such as tiredness, shortness of breath, pain, low mood, worry, and trouble sleeping.   The program can be completed by phone or secure video call, so you can take part from the comfort of your home or a private place of your choosing.You may be eligible if you are 40 years of age or older, have heart failure, and you see a primary care provider and a cardiologist (heart doctor) through IU Health. 

RADIANT aims to discover and define rare and atypical forms of diabetes among individuals and families, by investigating and defining their molecular and metabolic bases, and developing processes as well as a database and biorepository to enhance further understanding of atypical diabetes by the broader research community. These refined diagnoses will be used by diabetes researchers, physicians, and patients to accurately explain their disease. This could also lead to better diagnoses, improved treatments, and potential prevention of these diseases.