Health Research
and Clinical Studies

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

Browse by Featured categories

Aging
Children, Families & Pregnancy
Dental
Online
Alcohol, Tobacco, and Substance Use
Alzheimer’s Disease & Dementia
Asthma,Lungs & Allergies
Bones, Muscles and Joints
Brain, Spine & Nervous System
Covid-19 & Infectious Disease
Diabetes, Heart and Blood Vessels
Digestive System (GI), Bowel & Liver
Health Mental, Behavioral Health & Developmental Conditions
Healthy Volunteer
Cancer
Diet, Nutrition, Exercise, & Sleep

Browse by Featured categories

Aging
Children, Families & Pregnancy
Dental
Online
Alcohol, Tobacco, or Other Substance Use
Alzheimer’s Disease & Dementia
Asthma,Lungs & Allergies
Bones, Muscles and Joints
Brain, Spine & Nervous System
Covid-19 & Infectious Disease
Diabetes, Heart and Blood Vessels
Digestive System (GI), Bowel & Liver
Health Mental, Behavioral Health & Developmental Conditions
Healthy Volunteer
Cancer
Diet, Nutrition, Exercise, & Sleep

Browse by Featured categories

Aging
Alcohol, Tobacco and Substance Use
Brain, Spine and Nerves
Cancer
Diabetes
Diet, Exercise and Nutrition
Healthy Volunteers
Mental and Behavioral Health
Alzheimer’s Disease and Dementia
Autoimmune Disease
Bladder and Kidneys
Bones, Muscles and Joints
Community and Environmental Health
Dental
Eye Conditions
Genetic and Rare Conditions
GI, Liver and Pancreas
Hearing, Speech and Language
Heart Health
Infectious Disease
Lungs, Asthma and Allergies
Maternal, Infant and Child Health
Online Studies
Public Health Studies
Skin and Wounds
Sleep
Surgery, Transplant and Imaging
Thyroid, Hormones and Metabolism

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Help Shape the Future of Health
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By donating a small blood sample, you can help researchers discover better treatments and improve health across Indiana.

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All IU Health Patients of Any Age

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What Is Involved?

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Why does it Matter?

By taking part, you're helping improve care for you, your loved ones, and people across Indiana.

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Browse studies by

Recently added/updated trials

 Mmmm! I'm All IN for Kidney Health! Join Our Chronic Kidney Disease and Diet Study Contact List

Mmmm! I'm All IN for Kidney Health! Join Our Chronic Kidney Disease and Diet Study Contact List

S
Sharon Moe, MD
19 years - 75 years
All genders
What you eat matters when you have chronic kidney disease (CKD)—and researchers want to learn what works best.The IU School of Medicine is studying how diet affects kidney health and invites people with CKD to join a nutrition research contact list. By signing up, you’ll be notified about studies that may be a good fit for you.Joining the contact list is easy and low‑commitment. You’re simply giving permission to be contacted—you can always decide whether or not to take part in a study.Your interest helps researchers learn more, improve nutrition guidance, and support better kidney health for people across Indiana.

LoTam: A Randomized, Phase III Clinical Trial of Low‐Dose Tamoxifen for Selected Patients with Molecular Low-risk Early‐Stage Breast Cancer

K
Kathy Miller, MD
18 years - 100 years
All genders
Phase 3
This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy to treat postmenopausal women with hormone-dependent breast cancer. Giving low dose tamoxifen may be more effective compared to usual hormone therapy in treating post-menopausal women with hormone-positive, HER2 negative early stage breast cancer.Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632

PSMAcTION: A phase II/III, open-label, international, multi-center, randomized study of AAA817 versus standard of care in the treatment of adult participants with PSMA-positive metastatic castration-resistant prostate cancer who progressed on or after [177Lu]Lu-PSMA targeted therapy.

N
Nabil Adra, MD
18 years - 100 years
Male
Phase 2/3
This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and progressed on or after [177Lu]Lu-PSMA targeted therapy.Treatment of interest: the investigational treatment is AAA817 regardless of subsequent anti-neoplastic treatment. The control treatment is investigator's choice of Standard of Care, regardless of subsequent anti-neoplastic treatment.Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office:Email: iutrials@iu.edu Phone: (317) 278-5632

A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)

T
Tarah Ballinger, MD
18 years - 60 years
Female
Phase 3
This study will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (for pN0 patients) and 0-25 (for pN1 patients). Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
 Does Diabetes Run In Your Family?  We Want To Hear From You

Does Diabetes Run In Your Family? We Want To Hear From You

18 years - 29 years
All genders
Does Type 2 Diabetes Run In Your Family?  Have You Ever Thought About Ways to Prevent It?  More people are being diagnosed with type 2 diabetes at a younger age than ever before. This study is for young adults (ages 18-29) who have a family history of type 2 diabetes. We want to hear what you think about diabetes prevention, what actually helps, and what makes it harder to stay on track. By taking part in a one-time online interview, you can help improve diabetes prevention programs so they better support young adults like you. 
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Online study
 ARE YOU PREGNANT OR A NEWLY EXPECTING MOM?  JOIN THE HEARTLAND STUDY!

ARE YOU PREGNANT OR A NEWLY EXPECTING MOM? JOIN THE HEARTLAND STUDY!

D
David Haas, MD
18 years - 40 years
Accepts healthy volunteer
Female
DID YOU KNOW?  Herbicides are widely used in the Heartland, and farmers are using these chemicals more than ever before. Several studies have raised concern that some of the herbicides  may be associated with reproductive disorders, certain birth defects, and developmental disorders. What are herbicides? Herbicides are a type of pesticide that are used to protect our food crops, trees, vines, and pastures from harmful weeds. Some herbicides are also used in and around our homes, parks, sports fields, and golf courses. Herbicide use has increased significantly since the 1990s and is projected to rise rapidly on corn and soybean farms in the Midwest for the next 5-10 years.  As more pounds are applied, higher levels of human exposure are expected.    What Is the Heartland Study?Mother-infant pairs living in the Midwest will be followed throughout pregnancy, infancy and early childhood to observe health and development in order to better understand the effects of prenatal herbicide exposures. Your participation will help researchers to increase their knowledge about how herbicide exposure might affect pregnancy, newborn health, child childhood development, and future generations.

A Phase 3B/4, Multicenter, Parallel-Group, Double-Blind, Placebo Controlled, Two-Arm, Long-Term Study to Evaluate the Safety and Efficacy of Saroglitazar Magnesium on Clinical Outcomes in Participants With Primary Biliary Cholangitis (Pbc)

R
Raj Vuppalanchi, MD
18 years - 100 years
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the effect of saroglitazar magnesium compared to placebo, based on time to the first occurrence of the defined clinical outcome events in participants with PBC.THIS STUDY IS ENROLLING BY INVITATION ONLY