Featured Clinical Studies
Prebiotics in Women’s Health and Aging: The Gut-Bone Connection
What is the purpose of this study?Dietary supplementation with dried plums has been shown to reduce bone loss in women. The purpose of this research study is to understand how dried plums are doing this by studying the immune cell, gut microbe, and bone responses.Who can take part?Women between the …
Step Strong. Stay Balanced. Join Our Foot Strength Study!
Foot strength is important for balance and how we move. Our study is looking at the relationships between foot strength, balance, gait, and footwear in people as they age. This information will help us understand whether footwear can be prescribed to help improve foot strength, balance, and fall risk in …
Stronger Hearts, Healthier Lives: Join Our Study
Why is this study being done?Cardiokidney Metabolic Syndrome or CKM is a new syndrome recognized by the American Heart Association and occurs when an individual has a combination of conditions which includes being overweight, in addition to having metabolic risk factors (hypertriglyceridemia [≥135 mg/dL], hypertension, metabolic syndrome, diabetes), or chronic …
Are You Having Trouble with Your Memory? Join Our Study!
Why is this study being done?Our team aims to understand how everyday stressful experiences are related to memory and thinking. Who can take part?You may be eligible if you are:65+ years oldHaving trouble with memory or thinkingHave seen a health provider within the past year
Adolescents Needed for Sweetened Beverages Study
Why is this study being done?The goal of this study is to better understand how preferences for sweet flavors affect dietary habits, heart and metabolic health. Who can take part?We are looking for adolescents (ages 12-18) who consume sugary sodas and their families (only one parent/guardian can participate). Participants must …
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Help Shape the Future of Health
with the Indiana Biobank
By donating a small blood sample, you can help researchers discover better treatments and improve health across Indiana.
Who Can Join?
All IU Health Patients of Any Age
What Is Involved?
It's easy-we collect a blood sample during your regular doctor visit.
Why does it Matter?
By taking part, you're helping improve care for you, your loved ones, and people across Indiana.
Recently added/updated trials
Phase I/II Trial of Lurbinectedin with Osimertinib in Transformed Small Cell Lung Cancer
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Misty D. Shields, MD, PhD
Primary Objective:To assess the efficacy of the combination of lurbinectedin with osimertinib in patients with EGFR altered non-small cell lung cancer (NSCLC) with documented transformation to SCLC, after the use of EGFR tyrosine kinase inhibitor osimertinib.Secondary ObjectiveTo evaluate the safety of the combination of lurbinectedin with osimertinib in patients with EGFR altered non-small cell lung cancer (NSCLC) with documented transformation to SCLC, after the use of EGFR tyrosine kinase inhibitor osimertinib.Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
CD4CAR T CELL THERAPY FOR AML
H
Huda Salman
This study is designed as a single arm open label traditional Phase I, 3+3, study of CD4-redirected chimeric antigen receptor engineered T-cells (CD4CAR) in patients with relapsed or refractory AML. the study will evaluate safety in this patient population and also the presence of efficacy signal described by elimination of residual disease to qualify patients for stem cell transplant. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
A Phase 1B, Open-Label, Multicenter, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of Ag-181 in Subjects With Phenylketonuria
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Melissa Lah, MD
This study is designed to evaluate the safety and efficacy of AG-181 in adults with phenylketonuria (PKU). People with the genetic condition phenylketonuria (PKU) have elevated levels of the amino acid phenylalanine (phe). Elevated levels of phe can lead to learning impairment, neuropsychological problems, ADHD, and other health problems. This study drug may stabilize the enzyme deficient in PKU (especially in patients with common genetic variants), restoring enzyme function and potentially providing a new treatment.THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential subjects will be identified from the practice of the PI and her colleagues within the same practice. Potential subjects may be contacted by the study team via phone or in person to introduce the study.
Families Needed for Nutrition Education Program Study!
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Heather Eicher-Miller
Looking to stretch your food dollars? We can help! Researchers at Purdue University are looking for families to be in a study about the Nutrition Education Program, which provides education to make healthy choices and planning and preparing family meals. Families in Indiana with a child ages 5-18, who also receive or are eligible for programs like the Supplemental Nutrition Assistance Program or food stamps, the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), free or reduced school lunch/breakfast, among others, are invited to participate. The goal of this study is to understand the impact of a nutrition education program on parents or legal guardians and school-aged child 5-18 years old in their household. Compensation will be provided.
Prospective Sample Collection Of Subjects For The Development Of Multiple Immunosuppressant Therapeutic Drug Monitoring Assays
A
Asif Sharfuddin
The primary aim of this study is to collect biological samples that may be used in the development of future multi-drug immunosuppressant therapeutic drug monitoring assays in solid organ transplant recipients.THIS STUDY IS ENROLLING BY INVITATION ONLY - The Investigator will collect samples from up to 3,000 adult subjects who have undergone a kidney, heart, or liver transplant and are currently prescribed Cyclosporine, Tacrolimus, Everolimus, Sirolimus, or Mycophenolic Acid (MPA) as part of their transplant care plan.
A Phase 3, Randomized, Double-Blind, 48-Week Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Dyne-101 Administered to Participants with Myotonic Dystrophy Type 1
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Laurie Gutmann
This Phase 3 study was designed based on the results of ACHIEVE. It is a randomized,double-blind study with a 48-week Placebo-Controlled Period to assess the efficacy, safety,and tolerability of DYNE-101 administered IV to participants with DM1 aged ≥16 years.This study is adequately powered to evaluate the effect of DYNE-101 50 mg/kg administeredQ8W compared to placebo on the primary efficacy endpoint of change from baseline in the5 times sit-to-stand (5×STS) test at Week 49 and address the significant unmet need for a safeand effective disease-modifying therapy to treat DM1.THIS STUDY IS ENROLLING BY INVITATION ONLY
Feasibility and Potential Efficacy of High-Intensity Gait Training in Individuals with Cerebellar Damage
T
T. George Hornby
The primary objective of this study is to determine the preliminary feasibility and safety of high intensity stepping training for individuals with chronic (>6 months) cerebellar damage. Additionally, the secondary aim of this study is to assess the comparative efficacy of high intensity stepping training and conventional training on locomotor recovery, specifically walking endurance.To date, no studies have attempted to maximize both the amount and cardiovascular intensity of stepping practice in patients with cerebellar disorders.THIS STUDY IS ENROLLING BY INVITATION ONLY - Recruitment will occur primarily from the inpatient and outpatient rehabilitation centers of the Rehabilitation Hospital of Indiana, with secondary sources of recruitment from surrounding rehabilitation facilities via flyers/laboratory contact information provided to associated clinical staff and providers.
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