The purpose of this study is to collect biosamples, in the form of whole blood, saliva, and tissue when available, to create a biorepository for people who have a hepatic adenoma or focal nodular hyperplasia (FNH) or both. Our goal is to find out why some women taking birth control pills develop rare liver tumors called hepatic adenomas. THIS STUDY IS ENROLLING BY INVITATION ONLY - Prospective participants will be clinic patients of the study investigators and will be recruited in-person at the time of their clinic appointment.  Subjects who have a hepatic adenoma or FNH will be invited to participate in the study. They will be identified by medical record review or at their doctor's visit.

The overarching goal of the registry is to expand knowledge and optimize practice in the transplantation of fecal microbiota or other gut microbial products. The objectives of this protocol regarding FMT for patients with acute severe/fulminant CDI include the following: • Establishing the effectiveness, safety, and optimal method of administration of FMT using donor stool or other GMTs in hospitalized patients with acute severe or fulminant CDI.• Characterize the impact of FMT and other GMTs on the resistome in hospitalized patients treated for acute severe or fulminant CDI.• Determine the impact of FMT and other GMTs on the virome and mycobiome via analysis of SMS data. THIS STUDY IS ENROLLING BY INVITATION ONLY - Subjects receiving FMT or other GMTs for a diagnosis of acute severe or fulminant CDI will be invited to join this registry. A formal medical history is completed bedside.

Experiencing the death of a loved one is hard.  We want to understand how a songwriting program can impact grief and resiliency in teens who have experienced the loss of aloved one. The purpose of this study is to learn more about how a songwriting program may affect grief and resiliency in adolescents that have experienced the loss of a loved one. We are also interested in learning how each adolescent experiences the songwriting program.  THIS STUDY IS ENROLLING BY INVITATION ONLY - Riley Grief Services will recruit teens ages 12-18 who have experienced a loss of a loved one that they are currently grieving by sending flyers through direct mailings to families already in the Riley Grief Services system as well as through sending flyers and/or providing in-service presentations to St. Vincent Bereavement Services, Community Health Network Bereavement, Brooke’s Place, Indiana University Health Hospice, through local school systems (e.g.., school counselors and social workers), and hospitals within the Indiana University Health System.

We propose a a prospective study with participants receiving personalized relaxing nature virtual reality (VR) intervention through a VR headset. Our goal is to test the feasibility, acceptability, tolerability and initial clinical efficacy of virtual reality intervention in reducing pain, anxiety, stress and delirium in patients after non major thoracic surgery. Patients will be prepared by trying the VR headset, optics (the headsets are designed to be worn over their glasses if needed) and fit adjusted make sure it is comfortable. Baseline assessment of pain, anxiety and delirium will be performed.THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients scheduled for surgery will be evaluated for entry into the study through chart review.  Eligible individuals and/or their legal representative will be approached for informed consent before their surgery in the preoperative clinic. 

The purpose of this study is to determine the prevalence rate of hearing loss and cerumen impaction in residents of senior living facilities and identify barriers to managing hearing devices and cerumen. Our long-term objective is to improve the effective identification and management of hearing health in senior living facilities. THIS STUDY IS ENROLLING BY INVITATION ONLY - Researchers will work with facility staff at senior living facilities to determine appropriate and convenient times and methods to inform residents about the study. We will coordinate with facility staff to schedule days where study staff will visit the facility and conduct the assessments. There will be sign up sheets where residents who are interested in the study can sign up for a time slot on the scheduled day of the assessments. Facility staff will look over the list of residents who signed up, and then help determine if the resident is able to consent for themselves. This decision will be based on their experience interacting with the resident on a day-to-day basis. They will not access any medical records for this determination. If residents are capable of consenting for themselves, the consent process will be conducted, and then the assessment will follow.

Endoluminal functional lumen imaging probe (EndoFLIP) is a minimally invasive, novel device that aids in the diagnosis of esophageal disorders. EndoFLIP is increasingly utilized for assessing esophageal biomechanics, yet normative data for children are lacking. Due to developmental differences in compliance and luminal size, adult reference values are not generalizable to pediatrics. This study aims to generate normative pediatric EndoFLIP values by performing brief esophageal measurements in children with no history of esophageal disease or symptoms who are already under anesthesia for colonic motility testing. This timing is optimal, as the anesthetic regimen used for colonic manometry catheter placement avoid s medications that typically alter esophageal parameters or motility findings.THIS STUDY IS ENROLLING BY INVITATION ONLY - Current patients of our pediatric GI division, scheduled for a colonoscopy with motility catheter placement in the Main OR, will be approached for participation. Families will be contacted in advance whenever possible, either during a clinic visit or via telephone prior to the procedure day, to allow adequate time for decision-making. Consent/assent will then be confirmed on the day of the procedure in the Main OR private room or obtained the day of the procedure only if prior contact was not practicable. Once signed, the EndoFLIP measurements will be obtained intraoperatively for 3-5 minutes prior to the colonic motility catheter placement.

This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. THIS STUDY IS ENROLLING BY INVITATION ONLY