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Found 147 results for Neoplasm
A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults with Cancer
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Tarah Ballinger, MD
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not …
FORAGER-1: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer with FGFR3 Alterations
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Tareq Salous
This is an open-label, multi-center, phase 1a/b study in participants with FGFR3-altered advanced solid tumors, including metastatic urothelial cancer (UC). The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435. LOXO-435 may be used to treat cancer of the cells that …
A Phase 1, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of the PTK7-Targeted Antibody-drug Conjugate DAY301 in Patients with Locally Advanced or Metastatic Solid Tumors
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Greg Durm, MD
This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and anti-tumor activity of DAY301, a PTK7-directed antibody-drug conjugate in patients with advanced or metastatic solid tumors. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive …
Circulating Tumor Dna in High-Risk Stage I and Clinical Stage II Germ-Cell Tumors
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Nabil Adra, MD
Circulating tumor DNA (ctDNA) is a biomarker that shows how well the body responds to treatment for a disease. Blood and tissue specimens will be collected from patients to find out whether ctDNA can be detected in those specimens so that tools can be developed to predict the presence (or …
A Phase 1, First-In-Human, Dose Escalation and Expansion Study to Evaluate the Safety and Tolerability of Xmab541 in Advanced Solid Tumors
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Nabil Adra, MD
The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study. The study will also evaluate the effect of XmAb541 on tumor outcomes.Interested in participating? For more information about this research …
Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT
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Nabil Adra, MD
This is an open label randomized phase II trial of maintenance oral etoposide vs. observationwith relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood(PBSCT). Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: …
Preember: A Phase 2, Open-Label Study Evaluating Imlunestrant in Premenopausal Women with Estrogen Receptor-Positive, Her2-Negative Breast Cancer
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Rina Yadav
Cohort 1: - Assess the effect of imlunestrant versus tamoxifen on tumor cell proliferation (Ki-67). - Assess the effect of imlunestrant versus imlunestrant + goserelin on tumor cell proliferation (Ki-67).Cohort 2: - Assess the rate of symptomatic or complex ovarian cysts with imlunestrant treatment without OFS.Interested in participating? For more information about …
A Non-randomized Open-label Multi-center Phase I/II Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Copanlisib in Pediatric Patients With Relapsed/Refractory Solid Tumors or Lymphoma
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James Croop, MD, PhD
This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy.
Evaluating Tolerability of Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT) with High Dose Rate Brachytherapy Boost for Unfavorable and Higher Risk Prostate Cancer
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Omar Ishaq
The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods. Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer doctor implants a small plastic tube …
A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)
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Tarah Ballinger, MD
This study will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) …
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