Found 147 results for Neoplasm
A listing of Neoplasm medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Randomized Phase Ii/Iii Study of Docetaxel and Ramucirumab with or Without Cemiplimab (Regn2810) for Participants Previously Treated with Platinum-Based Chemotherapy and Immunotherapy for Stage Iv or Recurrent Non-Small Cell Lung Cancer (Lung-Map Non-Matched Sub-Study)
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Rohan Maniar
This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel and ramucirumab alone in treating patients with non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Cemiplimab is a monoclonal antibody …
An Open-Label, Randomized Study of Bms-986489 (Atigotatug + Nivolumab Fixed-Dose Combination) Vs Durvalumab as Consolidation Therapy Following Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (Tigos-Ls)
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Misty D. Shields, MD, PhD
This is an open-label, randomized study of BMS-986489 (atigotatug + nivolumab fixed-dose combination) vs durvalumab in limited-stage (LS)-small-cell lung cancer (SCLC) participants.The main goals of this study are to:Evaluate the efficacy of BMS-986489 vs durvalumabEvaluate the safety profile of BMS-986489Interested in participating? For more information about this research study or …
A Randomized Phase III Trial Incorporating Pathologic Complete Response in Participants with Early Stage Non Small Cell Lung Cancer to Optimize Immunotherapy in the Adjuvant Setting (Insight)
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Rohan Maniar
This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells …
Docetaxel Addition In Metastatic Castrate-Sensitive Prostate Cancer (Aspire)
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Nabil Adra, MD
This phase III trial compares the effect of adding docetaxel to hormonal therapy and apalutamide versus hormonal therapy and apalutamide alone in treating patients with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Docetaxel is in a class of …
A Phase 3, Double-Blind, Placebo-Controlled, Randomized Study to Assess the Efficacy and Safety of Asp3082 in Combination with Mfolfirinox or Nalirifox as First-Line Treatment in Participants with Kras G12D-Mutated Metastatic Pancreatic Adenocarcinoma
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Anita Turk, MD
This study is a phase 3, double-blind, placebo-controlled, multicenter study of ASP3082 for the first-line treatment of participants with metastatic PDAC with KRAS G12D mutation in combination with mFOLFIRINOX or NALIRIFOX. The study will be conducted in approximately 250 study sites across Europe, Asia Pacific and the Americas (to ensure …
Together for Tomorrow: Explore New Treatment Options for Lung Cancer
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Vijaya L. Kakani, MD
We understand that living with non-small cell lung cancer (NSCLC), especially with the KRAS G12C mutation, can be incredibly challenging. Many people with lung cancer go through hard treatments and tough side effects. That's why we're inviting adults (ages 18 and older) who have advanced or metastatic nonsquamous NSCLC to participate …
Targeted Prevention of Postpartum-Related Breast Cancer
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Tarah Ballinger, MD
This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) patients with benign breast disease planning to have a breast biopsy. Chronic inflammation may increase the risk of postpartum related breast cancer. Low-dose aspirin is a non-steroidal anti-inflammatory drug. Giving low-dose aspirin may …
Comparing Stigma in Lung Cancer to Other Tobacco-Related Cancers: A Study from End Lung Cancer Now
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Bharathi Muthusamy
This is a descriptive, cross-sectional study, which will involve a one-time survey for patients with lung cancer (any histology), pancreatic adenocarcinoma, renal cell carcinoma, and urothelial carcinoma. Patients in this study will be recruited in a prospective basis during their in-person visit to the outpatient Multi-D Subspecialty Oncology Clinic visits at …
GRONINGEN INTERNATIONAL STUDY ON SENTINEL NODES IN VULVAR CANCER III, A PROSPECTIVE PHASE II TREATMENT TRIAL
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Sharon E. Robertson
The primary objective of this study is to investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer patients with a macrometastasis (>2mm) and/or extracapsular extension in the SN. The secondary objective is to evaluate the short and long-term morbidity associated with the SN procedure and …
A phase 2, randomised, multi-centre, open label trial to evaluate the safety and efficacy ofintravesical nadofaragene firadenovec alone or in combination with chemotherapy(gemcitabine and docetaxel) or immunotherapy (pembrolizumab) in subjects with high-grade Bacillus Calmette-Guerin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC) (ABLE-22)
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Hristos Kaimakliotis, MD
The pivotal phase 2 trial (rAd-IFN-CS 003) evaluating the efficacy of nadofaragene firadenovec showed that 55 (53.4%) of 103 subjects with CIS ± high-grade Ta/T1 achieved a complete response (CR) at 3 months. In this trial, the safety and efficacy of intravesical instillation of nadofaragene firadenovec alone or in combination …
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