Health Research
and Clinical Studies

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

Browse by Featured categories

Aging
Children, Families & Pregnancy
Dental
Online
Alcohol, Tobacco, and Substance Use
Alzheimer’s Disease & Dementia
Asthma,Lungs & Allergies
Bones, Muscles and Joints
Brain, Spine & Nervous System
Covid-19 & Infectious Disease
Diabetes, Heart and Blood Vessels
Digestive System (GI), Bowel & Liver
Health Mental, Behavioral Health & Developmental Conditions
Healthy Volunteer
Cancer
Diet, Nutrition, Exercise, & Sleep

Browse by Featured categories

Aging
Children, Families & Pregnancy
Dental
Online
Alcohol, Tobacco, or Other Substance Use
Alzheimer’s Disease & Dementia
Asthma,Lungs & Allergies
Bones, Muscles and Joints
Brain, Spine & Nervous System
Covid-19 & Infectious Disease
Diabetes, Heart and Blood Vessels
Digestive System (GI), Bowel & Liver
Health Mental, Behavioral Health & Developmental Conditions
Healthy Volunteer
Cancer
Diet, Nutrition, Exercise, & Sleep

Browse by Featured categories

Aging
Alcohol, Tobacco and Substance Use
Brain, Spine and Nerves
Cancer
Diabetes
Diet, Exercise and Nutrition
Healthy Volunteers
Mental and Behavioral Health
Alzheimer’s Disease and Dementia
Autoimmune Disease
Bladder and Kidneys
Bones, Muscles and Joints
Community and Environmental Health
Dental
Eye Conditions
Genetic and Rare Conditions
GI, Liver and Pancreas
Hearing, Speech and Language
Heart Health
Infectious Disease
Lungs, Asthma and Allergies
Maternal, Infant and Child Health
Online Studies
Public Health Studies
Skin and Wounds
Sleep
Surgery, Transplant and Imaging
Thyroid, Hormones and Metabolism

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Browse studies by

Recently added/updated trials

A phase 1b/2, multicenter, adaptive, double-blind, randomized, placebo-controlled study to assess the safety, tolerability, immunogenicity, and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in adults with Down syndrome (ABATE)

J
Jill Fodstad
35 years - 50 years
All genders
Phase 1/2
Interventional
What is this study about?The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndrome.This phase 1b/2 study will be in 2 parts. Study Part 1 will involve subjects with prodromal Alzheimer's disease. Study Part 2 will involve subjects with Down syndrome. THIS STUDY IS ENROLLING BY INVITATION ONLY

A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacokinetics of ION269 in Adults with Down Syndrome and Adults with Early Symptomatic Alzheimer's Disease (HERO Study)

J
Jill Fostad
35 years - 55 years
All genders
Phase 1/2
Interventional
The purpose of this study is to evaluate the safety and tolerability of ION269 in cognitively stable participants with DS who have evidence of brain amyloid positivity via amyloid-PET scanTHIS STUDY IS ENROLLING BY INVITATION ONLY
 Advancing Hispanic Outreach and Recruitment Science in Alzheimer's Disease and Related Dementias (AHORA!)

Advancing Hispanic Outreach and Recruitment Science in Alzheimer's Disease and Related Dementias (AHORA!)

P
Patricia Garcia
55 years - 100 years
All genders
Observational
What is the purpose of this study?Social determinants of health are nonmedical factors that influence health outcomes. Adverse social determinants of health negatively affect high risk populations who are at greater risk of dementia and other medical diseases. Just as important is the concerning fact that these high risk populations often do not take part in research studies that look to create treatments for Alzheimer’s disease and related dementias. This is why the Indiana University School of Medicine Department of Neurology in collaboration with the Indiana Alzheimer’s Disease Research Center look to understand what the barriers are that diminish engagement with research, as well as motivating factors to participate in a study. This understanding will help us develop strategies that will increase interest levels in research participation and eventually develop new therapies for Alzheimer’s disease.¿Cuál es el propósito de este estudio?Los determinantes sociales de la salud son factores no médicos que influyen en los resultados de salud. Estos determinantes afectan negativamente a las poblaciones de alto riesgo, que presentan un mayor riesgo de demencia y otras enfermedades. Igualmente importante es el preocupante hecho de que estas poblaciones de alto riesgo a menudo no participan en estudios de investigación que buscan desarrollar tratamientos para la enfermedad de Alzheimer y las demencias relacionadas. Por ello, el Departamento de Neurología de la Facultad de Medicina de la Universidad de Indiana, en colaboración con el Centro de Investigación de la Enfermedad de Alzheimer de Indiana, busca comprender las barreras que disminuyen la participación en la investigación, así como los factores que motivan la participación en un estudio. Este conocimiento nos ayudará a desarrollar estrategias que aumenten el interés en la participación en la investigación y, con el tiempo, desarrollen nuevas terapias para la enfermedad de Alzheimer.
Learn More
Online study
 Adolescents Needed for Sweetened Beverages Study

Adolescents Needed for Sweetened Beverages Study

N
Nana Gletsu Miller
12 years - 18 years
All genders
Why is this study being done?The goal of this study is to better understand how preferences for sweet flavors affect dietary habits, heart and metabolic health. Who can take part?We are looking for Black/African American and Latine adolescents (ages 12-18) who consume sugary sodas and their families (only one parent/guardian can participate). Participants must also be able to attend study visits at the Nutrition Research Center on either IU Indianapolis or IU Bloomington campus or Purdue University (West Lafayette).

A Phase 3, Open-label, Multicenter, Randomized Study to Evaluate the Efficacy and Safety of Romosozumab Compared with Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

E
Erik Imel, MD
5 years - 17 years
All genders
Phase 3
Interventional
What is the purpose of this study?The primary objective of this study is to evaluate the effect of romosozumab treatment for 12-months compared with bisphosphonate(s) on the number of clinical fractures at 12-months; the number of any fractures at 12-months and change in lumbar spine bone mineral density (BMD) Z-score at 6-months. 

A Phase 1 study of GRN163L (Imetelstat, IND# 170891, NSC# 754228) in combination with fludarabine and cytarabine for patients with acute myeloid leukemia that is in second or greater relapse or that is refractory to relapse therapy; myelodysplastic syndrome or juvenile myelomonocytic leukemia in first or greater relapse or is refractory to relapse therapy

B
Brian Weiss
1 year - 18 years
All genders
Phase 1
This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that has not responded to previous treatment (refractory) or that has come back after a period of improvement (recurrent). Imetelstat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as fludarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving imetelstat in combination with fludarabine and cytarabine may work better in treating patients with refractory or recurrent AML, MDS, and JMML.THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate clinical trial(s) at the time of their routine clinic visit. Occasionally, a patient may be a self-referral or physician referral, but are still screened for appropriate clinical trials at the time of their routine clinic visit. PI and staff may send copies of relevant consent forms to these patients to look over prior to actually consenting or enrolling them. This may take place at the patient's visit at which the consent is presented or the patient's next visit to the outpatient hematology/oncology clinic. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
 FIT Core - Musculoskeletal Function Imaging and Testing (MSK-FIT) Resource Core

FIT Core - Musculoskeletal Function Imaging and Testing (MSK-FIT) Resource Core

S
Sharon Moe, MD
S
Stuart Warden
5 years - 100 years
Accepts healthy volunteer
All genders
We are looking for people of all ages, regardless of health condition, to take part in a study that is looking for new treatments for bone and muscle disorders.Bone and muscle disorders are the leading cause of disabilty in the United States. Researchers want to find out more about how people are affected by aging, injury, disease and illness. Your participation will help advance the diagnosis and treatment of bone and muscle disorders.