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Help Shape the Future of Health
with the Indiana Biobank
By donating a small blood sample, you can help researchers discover better treatments and improve health across Indiana.
Who Can Join?
All IU Health Patients of Any Age
What Is Involved?
It's easy-we collect a blood sample during your regular doctor visit.
Why does it Matter?
By taking part, you're helping improve care for you, your loved ones, and people across Indiana.
Recently added/updated trials
Bowel Continence Across the Lifespan in People with Spina Bifida
K
Konrad Szymanski, MD
The purpose of this study is to compare these two types of enema programs in children and adults with spina bifida across the United States. We want to learn about how well enemas work to prevent bowel accidents and other bowel problems, how well people can do their enemas on their own, how often people have enema problems, and the quality of life of people who use enemas.THIS STUDY IS ENROLLING BY INVITATION ONLY - This study is identifying and enrolling children age 5 and older and adults with myelomeningocele followed at pediatric and adult multidisciplinary spina bifida clinics across the United States. Eligibility will be screened through study coordinator review of the electronic medical record and/or in discussion with clinicians in the SB clinic that participants are being recruited from. Children and adults with MM who are starting a new enema program or switching from one enema program to another will be recruited and enrolled prior to initiation of the new enema program.
Struggling With Depression? Learn About A Study Exploring New Options For Adults Living With Treatment-Resistant Depression
S
Susan Conroy, MD PhD
Still searching for relief from depression? Have you tried multiple treatments for depression without success? You may have another option.When treatments haven’t worked, research may offer a new path. The Abbott TRANSCEND study is a research study for adults with depression who have not felt better after trying at least four different antidepressant medications. The purpose of the study is to learn how safe and effective a treatment called deep brain stimulation (DBS) may be for people with treatment-resistant depression. DBS uses a medical device made by Abbott to deliver gentle electrical signals to specific areas of the brain. This treatment is still being studied and is not yet approved for this use.You may qualify to join this study if you:Are between the ages of 22 and 70Have been diagnosed with depression and are currently experiencing a depressive episode for at least 12 monthsHave tried at least 4 different treatments without successAre willing and able to attend regular study visits at the IU Health Neuroscience Center in Indianapolis, IN over the course of 3 years Please visit this link to complete registration to be contacted for this study: https://redcap.link/TRANSCEND
A Multicenter, Open-label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 Years Undergoing Cardiac Surgery
B
Brandon Tanner
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 to less than 6 years of age undergoing cardiac surgery, utilizing local infiltration analgesia (LIA). THIS STUDY IS ENROLLING BY INVITATION ONLY - Pediatric subjects aged 0 to less than 6 years of age identified by the research team as having postsurgical analgesia undergoing cardiac surgery, utilizing local infiltration analgesia (LIA) will be invited to participate.
A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early Vs Rescue Plasma Exchange (Timely-Plex)
D
Devon Mackay
The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.THIS STUDY IS ENROLLING BY INVITATION ONLY
Are You Caring For A Loved One With Cancer? We’d Love To Hear From You
V
Victoria Champion
Help us learn how to better support rural families facing cancer. Take part in this study and help improve care for caregivers like you. Caregivers play a vital role in helping cancer patients get the best possible care. But caregiving—especially in rural communities—can be demanding and emotionally overwhelming. Many caregivers face challenges related to stress, mental health, and balancing complex at‑home treatment responsibilities. Rural caregivers often face additional barriers such as fewer local resources and longer travel distances for care.That is why researchers at Indiana University are looking to speak with caregivers of people with colorectal or lung cancer who live in rural areas of Indiana.Your experiences matter. By sharing your story, you can help shape better care for other caregivers and the people they love.
An open-label, phase II proof-of-concept study to evaluate the clinical efficacy and safety of tapinarof for adult patients with palmoplantar keratoderma
D
David Rosmarin
What is the purpose of this study?This study is being done to find out how safe and how well the drug Tapinarof (VTAMA) works for stopping or treating palmoplantar keratoderma, which is a condition characterized by thickened skin on your palms and soles. Tapinarof, used as a topical 1% cream, is a naturally occuring compound used for the treatment of psoriasis. While Tapinarof has been cleared by the FDA for treating psoriasis exclusively, its potential use for palmoplantar keratoderma still needs to be explored. Your participation in this study will contribute to providing valuable information that may lead to potential approval for palmoplantar keratoderma in the future. Who can take part?Anyone ages 18 and older who has palmoplantar keratoderma.Additional informationThe study is being conducted by Dr. David Rosmarin at the Indiana University School of Medicine, Department of Dermatology.. It is funded by Dermavant Sciences, who is also the manufacturer of the drug.
A 2-stage, Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus
D
David Rosmarin
What is the purpose of this study?This study aims to evaluate the efficacy and safety of subcutaneous (SC) anifrolumab versus placebo in adult participants with cutaneous lupus erythematosus (CLE).
