Health Research
and Clinical Studies

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

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All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

Learn more

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Recently added/updated trials

Indiana Biobank - Donate A Blood Sample and Help Us Discover New Medical Treatments for Indiana Residents!

Indiana Biobank - Donate A Blood Sample and Help Us Discover New Medical Treatments for Indiana Residents!

T
Tatiana Foroud
100 years or below
Accepts healthy volunteer
All genders
The Indiana Biobank is a statewide research study, co-developed by Indiana University School of Medicine and IU Health to collect blood specimens. The Indiana Biobank is a collection of biological samples (like blood, urine, and tissue) from individuals matched with their electronic health information. Researchers use biobanks to study genetic factors in health and disease. Researchers use the samples and information to find new and/or better treatments for diseases and health conditions. IU Health patients can participate in this effort by donating a blood sample. These samples are collected at the time of a routine blood draw for their doctor. The Indiana Biobank can also use blood specimens left over from another draw. The goal of the project is to enroll 300,000 IU Health patients over the next five years. Collected samples and medical information are made available to scientists who are performing research that may lead to new or advanced medical treatments. We hope these discoveries will help improve the health of Hoosiers and the community. Watch this video to learn more:
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A Phase 1, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of the PTK7-Targeted Antibody-drug Conjugate DAY301 in Patients with Locally Advanced or Metastatic Solid Tumors

G
Greg Durm, MD
18 years - 100 years
All genders
Phase 1
This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and anti-tumor activity of DAY301, a PTK7-directed antibody-drug conjugate in patients with advanced or metastatic solid tumors. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
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Synaptic Therapy Alzheimer's Research Trial (START): A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease over 18 Months

J
Jared Brosch, MD
18 years - 85 years
All genders
Interventional
This is a multicenter randomized, double-blind, placebo-controlled Phase 2 study designed to evaluate the efficacy, safety, and tolerability of two doses of CT1812 compared to placebo in participants diagnosed with early Alzheimer's disease. THIS STUDY IS ENROLLING BY INVITATION ONLY
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A Phase 3, Open-label, Uncontrolled Single-arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Avacopan in Combination With a Rituximab or a Cyclophosphamide-containing Regimen in Children from 6 Years to 18 Years of Age with Active ANCA-associated Vasculitis (AAV)

S
Stacey Tarvin, MD
6 years - 17 years
All genders
Phase 3
Interventional
The rationale of this phase 3 study is to explore whether avacopan combined with a rituximab (RTX) or cyclophosphamide (CYC)-containing regimen is safe and effective in inducing and maintaining remission in pediatric subjects with active ANCA-associated vasculitis (AAV). The findings from this study may establish avacopan as an effective and safe therapeutic option when used with a RTX or CYC-containing regimen in pediatric subjects with active AAV. If this combination therapy demonstrates improved efficacy and safety, it could potentially become a recommended therapeutic option in clinical practice. In addition, understanding the pharmacokinetic (PK) parameters of avacopan will aid in optimizing dosing regimens in pediatric subjects, leading to improved therapeutic outcomes and reduced toxicity. THIS STUDY IS ENROLLING BY INVITATION ONLY
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Effect of S-Adenosylmethionine (SAMe) in Patients with Alcoholic Cirrhosis

S
Suthat Liangpunsakul, MD
18 years - 70 years
Accepts healthy volunteer
All genders
The proposed of this randomized, double blinded, placebo-controlled study is to assess the effect of SAMe compared to placebo in patients with alcoholic cirrhosis Child Class A and B. The primary objective of the study is to test relationship between SAMe (S-adenosylmethionine) supplement on liver function. The hypothesis is that SAMe supplement will improve liver function in patients with alcoholic liver disease. The improvement in liver function will lead to the reduction in all-cause mortality in patients with alcoholic cirrhosis in those who receive SAMe supplement when compared to those receiving placebo.The main purpose of this study is to see whether SAMe, a dietary supplement, will effectively help patients with alcoholic cirrhosis by improving liver function.THIS STUDY IS ENROLLING BY INVITATION ONLY - Research personnel will contact potential case study subjects via phone call or face-to-face in clinic.
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The Cardiogenic Shock Working Group Registry

O
Onyedika Ilonze
18 years - 100 years
All genders
The Cardiogenic Shock Working Group Registry is a multicenter registry of patients admitted for cardiogenic shock. The objective of the registry is to collect limited data set clinical variables from the medical records from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes. Lack of a central database for cardiogenic shock has limited analysis of cardiogenic shock to small group studies; the construction of a large collaborative database will provide the foundation for higher-power analysis in the future.   THIS STUDY IS ENROLLING BY INVITATION ONLY - A review of all medical records will take place in order to evaluate whether subject meets inclusion/exclusion criteria. The records that are reviewed will be based on the protocol’s listed inclusion exclusion criteria. Patients with cardiogenic shock will be approached for consent to participate in the prospective arm of the study. All eligible subjects may be approached any time during Index Hospitalization and up to 40 days post discharge.
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A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (JOURNEY)

M
Marc Rovner
18 years - 100 years
All genders
Phase 3
Interventional
The purpose of this study is to compare the effect of tezepelumab with placebo on moderate or severe COPD exacerbations in participants with moderate to very severe COPD. THIS STUDY IS ENROLLING BY INVITATION ONLY
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