Health Research
and Clinical Studies

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

All IN for Health provides a list of hundreds of active health studies happening right here in Indiana. These health studies are conducted by faculty at Indiana University, Purdue University, and the University of Notre Dame.

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Brain, Spine & Nervous System
Covid-19 & Infectious Disease
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Browse by Featured categories

Aging
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By donating a small blood sample, you can help researchers discover better treatments and improve health across Indiana.

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All IU Health Patients of Any Age

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Browse studies by

Recently added/updated trials

A Single Arm Phase 4 Trial to Evaluate the Safety and Efficacy of Oral Fruquintinib in the Treatment of Refractory Metastatic Colorectal Cancer in Patients from Minority Populations Underrepresented in Prior Fruquintinib Studies

A
Anita Turk, MD
18 years - 100 years
All genders
Phase 4
High blood pressure (hypertension) is a known side effect of the treatment with fruquintinib. Current research does not provide a clear answer whether minority groups such as Black/African American and/or Hispanic/Latino with refractory metastatic colorectal cancer (mCRC) have a bigger risk of higher blood pressure after treatment with fruquintinib. The main aim of this study is to learn how often adults of a minority group experience hypertension after they have been treated with fruquintinib for refractory mCRC. Other aims are to learn how safe fruquintinib is and how well it is tolerated by participants. Interested in participating? For more information about this research study or other cancer-related clinical trials at IU Simon Comprehensive Cancer Center, please contact:IU Clinical Trials Office Email: iutrials@iu.edu Phone: (317) 278-5632
 Your Health Information, Your Privacy: Older Adults Learning with an AI Chatbot Helper

Your Health Information, Your Privacy: Older Adults Learning with an AI Chatbot Helper

A
Aqueasha Martin-Hammond
60 years or above
Accepts healthy volunteer
All genders
We are conducting a research study to better understand how older adults interact with a health-related chatbot to make it easier for individuals to get health information. We want to hear your thoughts about using chatbots for health information and address any concerns you might have.  Study participation involves interacting with a chatbot during an online session that will require approximately 60-90 minutes of your time. You may be interested in participating if you are 60 years of age or older and have some familiarity or interest in using intelligent assistants like chatbots for health information. 
Learn More
Online study
 Simple auditory abilities and effects of acoustic-phonetic variability on perceptual processing in autism

Simple auditory abilities and effects of acoustic-phonetic variability on perceptual processing in autism

K
Karen Forrest
14 years - 20 years
Accepts healthy volunteer
All genders
What is it about?The purpose of the study is to learn about how adolescents and young adults with autism listen to different types of sounds, including spoken language.  Who is leading the study?Rachel Kasthurirathne, MA, CCC-SLP is a doctoral student at Indiana University Bloomington. She is conducting the study under the supervision of Dr. Karen Forrest. 
 The Indiana Myeloma Registry

The Indiana Myeloma Registry

A
Attaya Suvannasankha, MD
18 years - 100 years
All genders
Observational
WHAT IS CANCER?WHAT IS MULTIPLE MYELOMA?WHAT IS THE STUDY ABOUT?What is cancer?Each cell in your body holds a copy of your DNA. This DNA tells your cells how to do their jobs, like when to copy themselves and when to delete. Your cells copy and delete all the time. This is normal and healthy.Sometimes during the copying process, a mutation (like a typo) happens in the DNA that your body can't correct. Your cells may begin losing their ability to do their normal jobs, copying too often, and taking up too much space. This is cancer.Multiple Myeloma is cancer of the plasma cellsPlasma cells are a type of white blood cell that help fight infections by making antibodies. They are created in the bone marrow.As the mutated plasma cells grow out of control, they take over the bone marrow, leaving less space for red blood cells. This leads to a condition called anemia, which is when the blood doesn't have enough red blood cells. Red blood cells carry oxygen through the body. Without enough red blood cells, the body can't get enough oxygen.The mutated plasma cells also may take over the bone,causing pain and bone fractures. As the bone breaks down, calcium leaks into the blood. High calcium in the blood is called hypercalcemia.Mutated plasma cells make an abnormal antibody called M-protein (monoclonal protein), which can cause blockages in the kidneys. This can lead to kidney dysfunction and failure.Multiple Myeloma happens over time, usually several years. At the early stages, it is called MGUS.As more and more plasma cells get mutations, it develops into a stage called Smoldering Myeloma.Active Multiple Myeloma is diagnosed when one or more of the main symptoms (called CRAB symptoms) start to develop. These symptoms are hypercalcemia, renal (kidney) dysfunction, anemia, and bone disease.There's still a lot we don't know about Multiple Myeloma. That's why research is so important.The Indiana Myeloma Registry is a study to better understand:Who is most likely to get Multiple Myeloma?What treatments work for which people?What causes Multiple Myeloma?We hope to improve treatment and, one day, find a cure.If you have Multiple Myeloma, MGUS, Smoldering Myeloma, or other plasma cell disorder, please consider joining the study.Study PartsSALIVA SAMPLEHEALTH HISTORY QUESTION­NAIREQUALITY OF LIFE QUESTION­NAIREAPPROVAL TO LINK TO YOUR MEDICAL RECORDWe'll mail you a kit!One time: online or by phoneEvery 3-12 months: online or by phoneSo we can follow how your treatments go without you doing extra work!Study EligibilityYou are eligible if these things are true about you:You are a male or female patient age 18 or older at the time of informed consentYou have been diagnosed with or are suspected to have one of the following:Monoclonal Gammopathy of Undetermined Significance (MGUS)Smoldering Multiple MyelomaMultiple MyelomaBony or Soft Tissue PlasmacytomaPrimary AmyloidosisPlasma Cell LeukemiaOther Plasma Cell Dyscrasias (including but not limited to light chain deposition disease, monoclonal gammopathy of renal significance, POEMS syndrome)you have questions about the study, email myeloma@iu.edu or call 317.278.0808.Click here to sign up

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

18 years or above
All genders
Phase 3
Interventional
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.

Supporting Caregivers: Strategies to Reduce Stress and Improve Well-Being

N
Navin Kaushal
18 years - 100 years
Accepts healthy volunteer
All genders
Why is this study being done?This study aims to explore ways to support caregivers of individuals with dementia in managing stress and improving their overall well-being. By understanding their challenges and needs, we hope to develop effective strategies and resources to enhance their health and quality of life.Who can take part?Formal caregivers (paid employees/volunteers who provide care in a formal setting) and informal caregivers (wives, husbands, partners, family members and friends who provide unpaid care) of an individual or loved one living with dementia.  
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Online study

Intrathecal Opioid Influence on Mirna Expression in Cerebrospinal Fluid of Patients with Chronic Abdominal Pain Secondary to Chronic Pancreatitis

R
Raheleh Rahimi, MD
18 years - 100 years
All genders
Observational
Management of chronic abdominal pain in patients with chronic pancreatitis could be challenging. Doing this study should help us understand the mechanisms involved in pain perception and hopefully help us better manage chronic abdominal pain.THIS STUDY IS ENROLLING BY INVITATION ONLY - The surgical schedule will be assessed daily by the research team to identify patients scheduled for surgery who may be eligible to participate in this study. All patients with chronic abdominal pain secondary to chronic pancreatitis presenting to the Indiana University Health Advanced Pain Therapies, who will be undergoing intrathecal catheter and pain pump implant and meet the inclusion/exclusion criteria will be presented the option to participate in the study.