The purpose of the study is to collect human serum from patients with uremia and healthy volunteers that will be used to create physiologically relevant cell culture models. These models will be used to study the impact of uremia on cardiovascular cells.THIS STUDY IS ENROLLING BY INVITATION ONLY - Recruitment will target uremic patients with advanced CKD (CKD stages 4-5D) or those with acute kidney injury (AKI) from our ambulatory CKD clinics or inpatient general nephrology services at our Academic Health Center (AHC). Patients from our ambulatory CKD clinics or inpatient general nephrology services at our Academic Health Center (AHC), as well as healthy ambulatory volunteers that satisfy inclusion and exclusion criteria and agree to participate will be consented by the research team; they may also be identified through the Musculoskeletal Function, Imaging and Tissue Resource Core (FIT) Core study, IRB number 170755085..The potential subjects will be contacted by phone or in-person by study staff during their inpatient stay or encounter at the ambulatory outpatient clinic. Information about the study may be discussed with interested potential subjects by research personnel via phone, email or in-person as preferred by the subject.

This study is being conducted to investigate whether blood flow and/or oxygenation in the brain of babies exposed to opioids during pregnancy can predict the severity of neonatal opioid withdrawal symptoms (NOWS). This study will use a novel, safe, non-invasive brain monitoring device to measure blood flow and oxygen levels in newborns who were exposed to opioids during pregnancy.THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants will be identified through routine review of postpartum/maternity, newborn nursery, and NICU census lists at Riley Hospital Maternity Tower and Eskenazi Health Hospital to determine preliminary eligibility. Eligible mothers of infants with prenatal opioid exposure and mothers of control infants will be approached by trained study personnel, who will explain the study and provide the opportunity to ask questions. Mother's who would like their infant(s) to participate will be consented in person in a private setting or by flexible consenting procedures.

The purpose of this study is to evaluate recovery and outcomes following cannulated Bone Bolt® screw system versus standard cannulated screw system fixation for LC-1 pelvic ring injuries. The devices being studied are not investigational and have been approved for use by the FDA. The study team is evaluating recovery and outcomes following surgical treatment of pelvic ring injuries.THIS STUDY IS ENROLLING BY INVITATION ONLY - The orthopaedic trauma team meets every morning to discuss the patients under orthopaedic care. Patients identified to between 18 and 80 years with operative LC1 pelvic ring injury, will be screened for study enrollment at that meeting. Patients with qualifying injuries will be flagged as potential candidates and further medical record review will be conducted by the study team.