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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Phase 1a/1b Study of the PI3Ka: RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

M
Mateusz Opyrchal, MD, PhD
18 years - 100 years
All genders
Phase 1/2
What is the purpose of this study?Phase 1a Dose Escalation/Cohort Expansion BBO-10203 Monotherapy Primary: To evaluate the safety and tolerability of BBO-10203, an inhibitor of the PI3Kα:RAS interaction, in subjects with locally advanced unresectable or metastatic (ie, advanced) HER2-positive BC; HR-positive, HER2-negative BC; KRAS mutant NSCLC; and KRAS mutant CRC. Secondary: To evaluate …
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Study on Investigational Medication for Alzheimer's Disease Treatment

J
Jared Brosch, MD
60 years - 85 years
All genders
Phase 1/2
This study investigates the use of an investigational medication for treating Alzheimer's disease, a condition that affects memory and thinking. The purpose of this study is to collect data on how well the investigational medication, which is a form of vitamin B3, reaches the spinal fluid. This will help understand …
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Investigating Support for Managing Oral Anticancer Medications in Breast Cancer Patients

K
Kathy Miller, MD
18 years - 100 years
All genders
This study investigates ways to support people with breast cancer who are taking oral anticancer medications. Breast cancer is a disease where cells in the breast grow out of control. Oral anticancer medications are drugs taken by mouth to help treat cancer. The purpose of this study is to develop …
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The effect of cell phone usage on cervical spinal alignment

J
Jamie L. Bradbury, MD
18 years - 100 years
All genders
Observational
What is the purpose of this study?Review the alignment parameters of previously obtained cervical x-rays and compare with daily cell phone usage reports from patients based upon recorded time on their phone as well as survey questions from the patients.THIS STUDY IS ENROLLING BY INVITATION ONLY -  A retrospective review …
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Factors Influencing Biomarker-Based Surveillance for Liver Cancer

L
Lauren Nephew
18 years - 85 years
All genders
This study investigates what influences patients to choose biomarker-based surveillance for liver cancer instead of the standard image-based method. Hepatocellular cancer, or HCC, is a type of liver cancer. The study aims to understand the motivations or barriers for patients when deciding on this new type of surveillance.Participants will have …
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Investigating an Investigational Device for Pulmonary Hypertension Risk in ILD Patients

O
Onyedika Ilonze
18 years - 100 years
All genders
Interventional
This study investigates the use of an ECG-based artificial intelligence (AI) device to assess the risk of undiagnosed pulmonary hypertension (PH) in patients with interstitial lung disease (ILD). The purpose of this study is to determine if the device can increase the rate of new PH diagnoses compared to the …
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Comparing Growth Monitoring Methods in Twin Pregnancies

H
Hiba Mustafa, MD
18 weeks - 100 years
All genders
Interventional
This study investigates the effectiveness of using different fetal growth charts for monitoring twin pregnancies. The purpose of this study is to compare traditional growth charts, designed for single babies, with charts specifically made for twins to determine which method better identifies babies at risk and reduces unnecessary medical interventions.Participants …
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Study of Mental Health in Young Children with Cystic Fibrosis

E
Emma Tillman
18 months - 11 years
All genders
Observational
This study investigates the prevalence and progression of mental health issues such as depression, anxiety, and behavior problems in children with cystic fibrosis (CF) aged 18 months to 11 years. Cystic fibrosis is a genetic condition that affects the lungs and digestive system. The study aims to fill the gap …
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Investigating Enema Programs in Individuals with Spina Bifida

K
Konrad Szymanski, MD
5 years - 100 years
All genders
Observational
This study investigates bowel continence in people with spina bifida, a condition where the spine and spinal cord don't form properly. The purpose of this study is to compare two types of enema programs in children and adults with spina bifida across the United States. Researchers want to learn how …
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Investigation of Sacral Neuromodulation System for Urinary Urgency Incontinence

C
Charles Powell, MD
22 years - 100 years
All genders
Interventional
The purpose of this study is to investigate the long-term safety and effectiveness of an investigational sacral neuromodulation system for patients experiencing urinary urgency incontinence. Urinary urgency incontinence is a condition where there is a sudden need to urinate that is difficult to control, leading to involuntary leakage of urine.Participants …
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