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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen

K
Kate Hawa
2 years - 21 years
Accepts healthy volunteer
All genders
Phase 4
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enemaushes. Subjects will have their microbiome sequenced prior to placement by obtaining a. Pre-antegrade continence enema placement results will be compared to fecalbtained at 0, 4, …
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Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy: A Prospective, Single-arm, Multi-center, Blinded-review, Phase 3 Diagnostic Performance Study

C
Clinton Bahler, MD
18 years - 100 years
Male
Phase 3
What is the purpose of this study?The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases. THIS STUDY IS ENROLLING BY INVITATION ONLY - Consistent with most oncology trials, patients are not actively “recruited,” but are screened by their physician for appropriate …
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Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

L
Leslie Hulvershorn, MD, MSc
10 years - 17 years
All genders
Phase 3
Interventional
This study investigates the safety and tolerability of an investigational medication in young people with schizophrenia or bipolar disorder. Schizophrenia is a mental disorder that affects how a person thinks, feels, and behaves. Bipolar disorder is a condition that causes extreme mood swings, including emotional highs (mania or hypomania) and …
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A Multicenter, Open-Label, Extension Clinical trial to evaluate Safety and Efficacy of Saroglitazar Magnesium in Participants with Primary Biliary Cholangitis (PBC)

R
Raj Vuppalanchi, MD
18 years - 100 years
All genders
Interventional
What is the purpose of this study?This clinical trial (a medical research study) is an open-label extension of a previous research study, SARO.21.001, which evaluates the efficacy (improvement in liver enzymes and lipid profiles) and safety (side effects) of Saroglitazar Magnesium in participants with a medical condition known as Primary …
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A Real-World Comparative Effectiveness Trial Of Treatment Strategies In Patients With Rheumatoid Arthritis: The RA-PRO (Patient-Reported Outcomes) Pragmatic Trial (RA-PROPR)

S
Sneha Pai
18 years - 100 years
All genders
Interventional
What is the purpose of this study?The purpose of the study is to assess whether replacing their current TNF-biologic with a non-TNF-biologic is superior to adding a targeted synthetic DMARD (disease-modifying anti-rheumatic) medication with active RA despite current TNF-biologic treatment. THIS STUDY IS ENROLLING BY INVITATION ONLY - Patients who have …
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A Prospective, Single-Arm Multi-Center Study of the HARMONIC 700, 5 mm Diameter Shears with Advanced Hemostasis in Pediatric Surgical Procedures (General) and Adult Surgical Procedures (General, Gynecological, Urological, and Thoracic)

T
Troy Markel, MD
110 years or below
All genders
Interventional
What is the purpose of this study?The main purpose of this study is to demonstrate acceptable performance and assess safety of the HARMONIC 700 Shears device in a post-market setting when used per the instructions for use in pediatric and adult surgical procedures.THIS STUDY IS ENROLLING BY INVITATION ONLY - …
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A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma

L
Lisa Landrum, MD, PhD, MS
18 years - 100 years
Female
Phase 2
What is the purpose of this study?This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily. Translational Objectives: 1. To preliminarily assess IHC hormone receptor expression and correlation …
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Offspring Neurodevelopment and Growth after Early Antihypertensive Therapy or Preeclampsia in Women with Chronic Hypertension and Pregnancy (CHAP Child)

D
David Haas, MD
100 years or below
All genders
Observational
What is the purpose of this study?This study is being conducted to evaluate the current state of knowledge regarding long-term child outcomes among children born to women with mild CHTN who received antihypertensive therapy in pregnancy or who had preeclampsia. This study will compare long-term outcomes, including neurodevelopment and growth. …
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MAGNITUDE: A Phase 3, Multinational, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

N
Noel Dasgupta
18 years - 100 years
All genders
Phase 3
Interventional
What is the purpose of this study?To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM. 
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A Phase 3, Randomized, Open-Label Study to Compare the Efficacy and Safety of Anitocabtagene Autoleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Multiple Myeloma

R
Rafat Abonour, MD
18 years - 100 years
All genders
Phase 3
What is the purpose of this study?The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory …
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