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Found 594 results for IU Health Enterprise System
A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Lt-Care (Liver Transplant-Community Access for Referral Equity) Applied
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Lauren Nephew
A previous study (25857) focused on developing a multilevel intervention addressing health related variables and other social/structural barriers faced by patients as the most prominent way to acknowledge and improve LT referral equity. The LT-CARE intervention has been designed and as a part of this protocol, will be delivered to …
A Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Peripheral Artery Disease: A Randomized, Double-Blind, Placebo Controlled Trial
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Rolf Kreutz, MD
The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks.THIS STUDY IS ENROLLING BY INVITATION ONLY
A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of Vamifeport in Adult Subjects with Hfe-Related Hereditary Hemochromatosis
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Eric Orman
This is a phase 2, multicenter, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study to assess vamifeport in adult participants with homeostatic iron regulator gene-related hereditary hemochromatosis (HFE-HH). The primary objective of the study is to assess the effect of vamifeport treatment on magnetic resonance imaging (MRI)-based liver iron concentration (LIC) in …
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and Efficacy of Efimosfermin Alfa in Participants With Biopsy-Confirmed F2- or F3-Stage Metabolic Dysfunction-Associated Steatohepatitis (Mash) (Zenith-1)
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Raj Vuppalanchi, MD
The purpose of this study is to assess the safety and efficacy of efimosfermin alfa in the resolution of steatohepatitis and improvement of liver-related clinical outcome compared to placebo in individuals with MASH and biopsy-confirmed F2- or F3-stage fibrosis.THIS STUDY IS ENROLLING BY INVITATION ONLY
Assessing Renal Health with At Home Renal Functional Reserve Testing
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Michelle C. Starr, MD
The purpose of this study is to establish and validate a method to quantify renal fitness in children and young adults at high risk for acute kidney injury (AKI) and chronic kidney disease (CKD) which we can use in children at high risk of CKD. We will do this by …
Long-Term Outcomes of Skull Base Repair for Spontaneous CSF Leaks
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Rick Nelson, MD
This is a prospective observational study with the purpose of evaluating the durability of the bone cement repair used to treat spontaneous cerebrospinal fluid leaks (SCSFL). Long-term follow-up data will be collected from the EMR from standard of care procedures. Additionally, subjects will be asked to complete a one-time questionnaire …
IU Health Hospital at Home for Elective Gastrointestinal Surgery
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Sanjay Mohanty
Hospital at home is being implemented as an alternative post-operative care delivery system for selected colorectal patients who meet medical and geographic criteria to be discharged directly home to the hospital at home program after surgery. The purpose of this study is to gain insight into the patient experience of …
Understanding Barriers to Alcohol Use Disorder Treatment and Digital Health Engagement Among Patients with Alcohol-Associated Liver Disease: A Mixed-Methods Formative Study
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Lauren Nephew
From the patient perspective, stigma and fear of judgment, especially in transplant-adjacent contexts, discourage disclosure of alcohol use and engagement in treatment. Structural challenges, including transportation barriers, unstable housing, caregiving responsibilities, and financial toxicity, further limit participation in treatment. Treatment readiness may also fluctuate with stress, episodes of hepatic decompensation, …
Characteristics and Outcomes of Fontan Associated Liver Disease in Children
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Chao Jarasvaraparn
What is this study about?The proposed project is a non-funded, multi-center study designed to evaluate the characteristics and outcomes of Fontan Associated Liver Disease in Children. We will start collecting data prospectively and retrospectively since January 2020. THIS STUDY IS ENROLLING BY INVITATION ONLY - Potential participants who had a Fontan …
Clinical Pharmacokinetics of Labetalol in Pregnancy
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Sara Quinney
What is this study about?This study will determine how plasma concentrations of labetalol, a medication commonly used to treat hypertension in pregnancy, change during and after pregnancy and how this may impact antihypertensive therapy. The study will also evaluate exposure of fetus/neonate to labetalol through cord blood and breast milk. Study …
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