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Found 594 results for IU Health Enterprise System
A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Investigating Methods for Child Mental Health Conditions
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Rebecca McNally Keehn
The purpose of the study is to learn more about children’s mental health. We are hoping to better understand how to predict and diagnose common mental health diagnoses in children.THIS STUDY IS ENROLLING BY INVITATION ONLY - A two-step process will be used to identify and screen potential participants. In …
A Phase Iii, Randomised, Double-Blind, Placebo-Controlled, Event-Driven Study to Assess the Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Renal Outcomes and Cardiovascular Mortality in Participants With Chronic Kidney Disease and High Blood Pressure
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Sharon Moe, MD
The purpose of this study is to investigate the efficacy, safety, and tolerability of baxdrostat in combination with dapagliflozin, compared with placebo and dapagliflozin, in reducing the risk of the composite of > 50% decline in eGFR, kidney failure, or CV death, in individuals with CKD and HTN.THIS STUDY IS …
A 52-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Group Sequential Study to Evaluate the Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-Cell Disease (Libra)
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Seethal Jacob, MD
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and safety of rilzabrutinib in participants with sickle-cell disease (SCD).THIS STUDY IS ENROLLING BY INVITATION ONLY
An Observational Study of Lung Screening in Individuals at High Risk for Lung Cancer Who Do Not Meet the Uspstf Criteria
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Julian Marin Acevedo
Study purposse: Describe the demographics, risk factors for lung cancer, and baseline Lung Rads score of individuals enrolled in this observational study. Using descriptive statistics, compare the demographics and Lung Rads score of the participants enrolled in this study with those participating in the NLST and NELSON studies. Using descriptive …
Multi-Modal Large Language Model-Empowered Talk Therapy for Older Adults with ADRD
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Malaz Boustani, MD
The purpose of this study is to test the usefulness and the effect of the Smart Virtual Reminiscence (SVR) therapy intervention on the Behavioral and Psychological Symptoms of Dementia (BPSD) of patients with Alzheimer’s Disease and Related Dementias (ADRD). BPSD refers to changes in behavior and mood that often occur in dementia, …
Phase 1 Imaging Study of 68Ga-R12961 in Advanced Solid Tumors
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Cindy Yuan
The goals of this study are:To describe the safety of 68Ga-R12961To describe preliminary imaging efficacy of 68Ga-R12961 in participants with advanced solid tumors.To compare 68Ga-R12961 positron emission tomography/computed tomography (PET/CT) scans with standard of care imaging in detecting tumor lesions among participants.To describe the image quality of 68Ga-R12961.To determine organ …
Molecular and Pathological Correlates of Treatment Outcome in Patients with Thymoma and Thymic Carcinoma
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Patrick Loehrer, MD
What is this study about?The major purpose of this research study is to obtain blood samples from child and adult patients diagnosed with thymoma and/or tissue samples from patients undergoing surgery for their thymoma. We will use these specimens to test for certain characteristics that we think will be useful …
Tissue Procurement Protocol for the Developmental Therapeutics Clinic National Cancer Institute (NCI)
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Anna Maria Storniolo, MD
What is the purpose of this study?Adult patients (18 years of age and older) and pediatric patients (younger than 18 years of age) who are being evaluated for and/or treated for cancer at the NIH Clinical Center and at participating sites will be entered onto this tissue procurement protocol for …
Trial of VQ Scanning to Reduce Contrast-Induced Nephropathy in Patients Evaluated for Pulmonary Embolism
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Alice Mitchell
The purpose of this study is to identify major causes of Acute Kidney Injury (AKI) in the emergency care and hospital settings, to effectively risk-stratify patients, and, ultimately, to prevent or minimize the extent of AKI and subsequent severe health outcomes. The overarching, long-term goal of this research study is …
Blood sample collection from PBC patients at Indiana University
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Craig Lammert, MD
Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts, which, if untreated, leads to fibrosis, biliary cirrhosis, and liver failure. Because liver transplantation remains the only curative option for PBC, the goals of treatment are to slow the …
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