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Found 645 IU Health Enterprise System trials

A listing of IU Health Enterprise System medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Ovarian Tissue Cryopreservation for Fertility Preservation in Pre and Post-Pubertal Children, Adolescents and Adults Facing a Fertility Threatening Diagnosis or Treatment Regimen

A
Amanda J. Saraf, DO
17 years or below
Female
What is the purpose of this study?Define and follow-up with the patients that undergo OTC for fertility preservation.Optimize techniques and quality assurance measures for freezing and thawing of ovarian tissue or gametesEstablish techniques for in vitro follicle maturation (IFM) or in vitro maturation of cumulus oocyte complexesInvestigate factors affecting successful …
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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

J
Jared Brosch, MD
18 years - 80 years
All genders
Phase 2/3
Interventional
What is the purpose of this study?To assess the safety, tolerability, biomarker, cognitive, and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves disease-related biomarkers and slows the rate of progression of cognitive or clinical impairment.THIS STUDY IS …
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Study on Autologous Stem Cell Transplant for Peripheral T-Cell Lymphoma in Remission

U
Utpal Dave, MD
18 years - 75 years
All genders
Phase 3
This study investigates the potential benefits of using high dose chemotherapy followed by a patient's own stem cells, known as an autologous stem cell transplant, in treating peripheral T-cell lymphoma. Peripheral T-cell lymphoma is a type of cancer that affects T-cells, which are part of the body's immune system. The …
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Research Study on Investigational Medication for HER2 Expressing Tumors

J
Jonathan L. Berkowitz, MD, PhD
18 years - 120 years
All genders
Phase 2
Interventional
This study investigates an investigational medication for treating certain tumors that express a protein called HER2. HER2 is a protein that can affect the growth of some cancer cells. The study includes different types of cancers such as bladder, biliary tract, cervical, endometrial, ovarian, pancreatic, and some rare tumors.Participants will …
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Enhancing shared decision-making to prompt and guide individualized care for people with Alzheimer's Disease and Diabetes

A
April Savoy
50 years - 85 years
All genders
Interventional
For patients and caregivers, ADRD-DM presents unique challenges for detecting and preventing hypoglycemia.Individualized care for people with ADRD-DM should be based on patient and caregiver goals along with patients’ cognitive and physical abilities, reported outcomes, and hypoglycemia risk, based largely on prior hypoglycemic events. Providing details of hypoglycemic events and risks …
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Study of Investigational Medication with Radiation Therapy for Diagnosed Brain Tumors

S
Sandeep Batra, MD
12 months - 21 years
All genders
Phase 1/2
Interventional
This study investigates the safety and effectiveness of combining an investigational medication with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG). Glioma is a type of cancer that occurs in the brain or spine, and it is …
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Investigating Cirrhosis Risk and Patient Outcomes in Emergency Care

A
Archita Desai, MD
18 years - 100 years
All genders
Observational
This study investigates the use of the Cirrhosis Risk Instrument for Stratifying Post Emergency Department mortality (CRISPE) tool in individuals with cirrhosis. Cirrhosis is a condition where the liver becomes scarred and its function is impaired. The purpose of this study is to validate the CRISPE tool prospectively to predict …
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Study of Investigational Medication for PIK3CA Related Overgrowth Spectrum

R
Rachael Schulte
2 years or above
All genders
Phase 2
Interventional
This study investigates a treatment for PIK3CA Related Overgrowth Spectrum (PROS), a condition caused by a mutation in the PIK3CA gene that leads to abnormal growths in the body. The purpose of this study is to evaluate the safety and effectiveness of an investigational medication targeting these mutations.Participants in this …
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Molecular Analysis of Factors Involved in Benign Reproductive Tract Diseases

S
Shannon Hawkins
18 years or above
Female
What is the purpose of this study?The purpose of this study is to collect female reproductive tract tissues to investigate the key molecular events regulating endometriosis. Our central hypothesis is that by using well-characterized tissues, we can create novel models to improve treatments for endometriosis. THIS STUDY IS ENROLLING BY INVITATION …
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Assessing the Effect of Vitamin C on Infant Lung Function When Given to Pregnant Women Who Smoke

R
Robert Tepper, MD
15 years - 100 years
Female
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